Karen Dixon

Beyond T cell exhaustion: TIM-3 regulation of myeloid cells We provide a comprehensive review of 20 years of research on TIM-3 functions in myeloid cells and T cell exhaustion.

@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!

29.04.2025 12:52 — 👍 10    🔁 4    💬 1    📌 0

Tremendously honoured to be recognised by the AACR among these fantastic scientists - Can't wait to hear more about the phenomenal work is doing! #AACR25 @theaacr.bsky.social

27.04.2025 13:28 — 👍 6    🔁 0    💬 0    📌 0

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Grateful to share our study on the potential for immune checkpoint blockade in late-onset #AlzheimersDisease out @nature.com today. Co-led with Kimi, Zhuoran, Ahad @kuchroolab.bsky.social in a big team effort @genelayinstitute.bsky.social @broadinstitute.org @harvardmed.bsky.social  /1

10.04.2025 03:39 — 👍 18    🔁 6    💬 1    📌 0

Enduring NREM sleep fragmentation following methotrexate chemotherapy in cancer-naïve mice AbstractStudy objectives. Sleep disruption is common in people with cancer and survivors, but understanding the mechanisms driving these problems is diffic

academic.oup.com/sleep/advanc... excited to share our lab’s first data paper, led by stellar lab tech Leah Boyd in a fun collab with @erinmgibson.bsky.social :) one step closer to understanding and combating chemotherapy-associated behavioral comorbidities.

20.03.2025 14:39 — 👍 9    🔁 1    💬 1    📌 1

A great collab with @jborniger.bsky.social lab showing persistent NREM sleep disturbances with chemotherapy exposure irrespective of cancer presence. Important work in our understanding of how cancer treatments can impart lasting neurological changes.

20.03.2025 15:07 — 👍 8    🔁 1    💬 0    📌 0

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...

19.02.2025 21:41 — 👍 75    🔁 23    💬 2    📌 0

Our paper in @nature.com is finally published: a prospective trial of a personalized Neoantigen Vaccine in Kidney Cancer

www.nature.com/articles/s41...

This is teamwork with @danafarber.bsky.social @yalecancer.bsky.social @harvardmed.bsky.social + Wu lab

www.nature.com/articles/s41...

05.02.2025 19:18 — 👍 28    🔁 15    💬 1    📌 1

Proposed cycle between nociceptive input and autonomic output in cancer. Sensitization of nociceptive sensory neurons by the tumor microenvironment leads to propagation of orthodromic signaling towards the central nervous system (CNS).

📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...

#neurobiology

30.01.2025 14:29 — 👍 6    🔁 3    💬 1    📌 0