Kuchroo Lab

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...

New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…

Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...

Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA

Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses a regulatory progr...

The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity.
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social
www.cell.com/cell-reports...

Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!

(1/6) Our latest paper in ‪@cp-cellhostmicrobe.bsky.social‬ shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
www.cell.com/cell-host-mi...

Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

Out now in @Science! We and the @kuchroolab.bsky.social described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity

www.science.org/doi/10.1126/...

We show that Th2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven clearance of gut pathogens🪱🪱.

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
www.science.org/doi/10.1126/...
@science.org @kuchroolab.bsky.social @thexavierlab.bsky.social

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity - Nature A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve o...

New research from @quintanalabhms.bsky.social show how glioblastoma co-opts TRAIL-positive astrocytes to suppress anti-tumor T cell function. Now published @nature.com
www.nature.com/articles/s41...

So great that Brenda & Jason gave us daily recaps of their favorite talks at #AAI2025 via @immunologypodcast.com.
🌟Episode 5 features a talk by Ana Anderson on how opioids drive immunosuppression in T cells in cancer.
Listen to all the episodes for highlights from the🧪 @aai.org conference👇

Immune-system strategy used to treat cancer may help with Alzheimer’s — Harvard Gazette Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.

A new study raises the odds that a strategy already successful against some cancers may be deployed against Alzheimer’s.
From @kuchroolab.bsky.social and colleagues, co-first authors Kimitoshi Kimura and @ayshwaryas.bsky.social
news.harvard.edu/gazette/stor...

Beyond T cell exhaustion: TIM-3 regulation of myeloid cells We provide a comprehensive review of 20 years of research on TIM-3 functions in myeloid cells and T cell exhaustion.

@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!

Psychedelics reduce fear by targeting immune cells that modulate brain cells Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.

Immune cells boost stress-linked fear responses by communicating with brain cells.

Psychedelics can modulate this interaction, lessening such fear

https://go.nature.com/4ixzclU

Immune-system strategy used to treat cancer may help with Alzheimer’s — Harvard Gazette Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.

Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the @harvard.edu Gazette 👇
🧪
news.harvard.edu/gazette/stor...

Psychedelic control of neuroimmune interactions governing fear - Nature Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

Nature research paper: Psychedelic control of neuroimmune interactions governing fear

https://go.nature.com/4iriy7u

Psychedelic control of neuroimmune interactions governing fear - Nature Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

Psychedelic compounds regulate neuroimmune interactions to control stress-induced fear.
Study from Michael Wheeler & colleagues @genelayinstitute.bsky.social,
@massgeneralbrigham.bsky.social @harvardmed.bsky.social. Now published @nature.com www.nature.com/articles/s41...

Psychedelic control of neuroimmune interactions governing fear - Nature Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

Congratulations to the Michael Wheeler lab et al. on this elegant study showing the underlying mechanisms of how psychedelics influence neuroimmune interactions, with implications for fear behaviour. Delighted to be able to contribute to this work. www.nature.com/articles/s41...

#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Nature research paper: Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

https://go.nature.com/4i6HG3r

Register for #ReThinkNeuroimmunology 2025 at
🔗 genelayinstitute.org/rtn/

🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/

Researchers at Mass. General Brigham gaining ground on Alzheimer’s disease - Boston News, Weather, Sports | WHDH 7News BOSTON (WHDH) - Some talented researchers at Mass General Brigham are gaining ground in the fight against Alzheimer’s through a new approach that manipulates molecules<a class="excerpt-read-more" href...

Nice media coverage of our recent study on how Tim-3 regulates microglial activity. #ButovskyLab @genelayinstitute.bsky.social.

Researchers @massgenbrigham.bsky.social @harvardmed.bsky.social gaining ground on Alzheimer’s disease whdh.com/news/researc... via @7NEWS