Marius Trollmann

Thanks! 😉

@biomemphys.bsky.social lab at #EBSA2025 in Rome! Happy to discuss recent work on membranes and LNPs at Posters and in Talk! @m-a-r-i-u-s.bsky.social @fau.de

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity Antimicrobial peptides (AMPs) are promising candidates for next-generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how var....

🚨 New Publication Alert! 🚨
Our latest review on antimicrobial peptides (AMPs) is now out in Small! 🧬✨
We cover different mechanisms of action of AMPs with a focus on the targeting of bacterial membranes. @fau.de @m-a-r-i-u-s.bsky.social
Check it out here:
doi.org/10.1002/smll...
#AMP #membranes

How many theoreticians do you need to unmount a kitchen? @fau.de

New study alert, published in PNAS! Our team revisits lipid nanoparticle composition and structure, challenging coarse-grained simulation approaches that may mask crucial pH-driven phase transitions. Discover how setups may bias LNP structures #LNP @fau.de
www.pnas.org/doi/10.1073/pnas.2422995122

The fragile flame of freedom flickers low, Its steady light consumed by shadows deep. Where once the people's will had room to grow, Now gilded towers rise while dreamers sleep. The streets grow quiet as the markets roar, The people lost in digital despair. No votes, no voice, but data to adore, Their power grows while we must gasp for air. Will oligarchs decide the terms of hate, And leave us slaves within their gilded dreams? Shall silicon and dollars write our fate, And bind us all and glue us to their screens? Beware, for tech may burn our hope to dust— In circuits cold, no justice can we trust.

Ich habe zusammen mit ChatGPT ein Sonett über die Bedrohung der Demokratie durch Tech-Bros geschrieben. Und jetzt weiß ich auch nicht mehr, was ich denken soll.

Mechanistic Insight into pH-Driven Phase Transition of Lipid Nanoparticles Lipid nanoparticles (LNPs) are essential delivery vehicles in mRNA-based vaccines, with their functionality largely governed by aminolipids. At low pH, protonated aminolipids facilitate efficient mRNA...

👉 Please have a look at the accompanying paper too! biorxiv.org/cgi/content/...

🚨 Preprint Alert! 🚨
Check out our new book chapter on Constant-pH MD Simulations of Lipids! Learn how to use CpHMD simulations to study pH-dependent behavior of aminolipids in lipid nanoparticles for drug delivery. 💊🧬
#membranes #LNP @m-a-r-i-u-s.bsky.social @fau.de
biorxiv.org/cgi/content/...

Mechanistic Insight into pH-Driven Phase Transition of Lipid Nanoparticles https://www.biorxiv.org/content/10.1101/2024.11.27.625717v1 Lipid nanoparticles (LNPs) are essential delivery vehicles in mRNA-based vaccines, with their functi

Mechanistic Insight into pH-Driven Phase Transition of Lipid Nanoparticles https://www.biorxiv.org/content/10.1101/2024.11.27.625717v1

Details at www.biomemphys.nat.fau.de/jobs/

🌟 Ph.D./Postdoc in Computational Membrane Biophysics 🌟
Join our team at @unifau.bsky.social to study Lugdunin, a unique antimicrobial peptide, using cutting-edge simulations. Collaborate with experts, access top-tier HPC, and advance antimicrobial science.
📩 Apply: rainer.boeckmann@fau.de
#membranes

🔑 Topics include:
• Membrane-targeting strategies of AMPs
• Composition, structure, and dynamics of bacterial membranes versus eukaryotic membranes
• AMPs design and discovery: From natural peptides to therapeutics

🚨 Review Preprint Alert 🚨
Discover how computational and experimental tools are employed in antimicrobial peptide (AMP) research for combating bacteria.
Great Collaboration with Eggeling and Gutsmann Labs
Read now on chemRxiv
#AntimicrobialPeptides #membranes @fau.de
chemrxiv.org/engage/chemr...

Phase transition of LNP lipid formulation

🚨 Preprint Alert 🚨pH-induced phase transitions in lipid nanoparticle (LNP) formulations are crucial for LNP function – but not all settings in MD simulations allow to observe these transitions...
#membranes #LNP @fau.de
arxiv.org/abs/2412.02731

LNP-mimetic membrane with mRNA (red)

Preprint alert! 🚨
"To be protonated or not to be protonated? That is the question! 🤔
In our latest study, we used constant-pH simulations to uncover the dynamic (de)protonation of ionizable aminolipids in Lipid Nanoparticles (LNPs).
#membranes @fau.de

Mechanistic Insight into pH-Driven Phase Transition of Lipid Nanoparticles Lipid nanoparticles (LNPs) are essential delivery vehicles in mRNA-based vaccines, with their functionality largely governed by aminolipids. At low pH, protonated aminolipids facilitate efficient mRNA...

🧪 With hundreds of titratable sites, we explored how these key components behave in the BioNTech & Pfizer LNP formulation.
Our findings reveal a fascinating pKa shift by more than 3 units and resolve a position-dependent protonation of aminolipids. biorxiv.org/cgi/content/...

Very grateful for research funding granted by #DFG to study antimicrobial peptide Lugdunin's selectivity for gram-positive bacteria. Thrilled to continue collaboration with Steinem Lab, Göttingen. Insights could pave the way for new strategies against resistant infections.
@UniFAU

Manged to get NVIDIA's GPU physics solver Warp running interactively inside of Blender. This is 500,000 particles simulating ON THE GPU and taking live inputs from the viewport #b3d #GeometryNodes

Nice work! :)

Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity - Nature ... Cholesterol both thickens and condenses membranes, yet it also softens them under certain conditions. Here, authors uncover cholesterol’s dual role in the delicate balance of rigidity and flexibilit...

🌟 Matthias Pöhnl & @MTrollmann reveal cholesterol's paradox in membranes: it both thickens and softens. Insights into this balancing act of rigidity and flexibility in Nat. Comm #FAU #membranes www.nature.com/articles/s41...