Dan Bose

I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions

At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.

Spot on.

Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more.

And they talk and TALK about how much they want to support junior careers..

What these decisions basically say, is that unless you work on one of the few areas that a select few people have decided might be important because they could make £££, or that you are fortunate enough to work in a place that can afford a press department, then what you do is worthless.

On a personal level, I think one of the hardest things is the implicit statement that the work that so many 1000's of us do, and the significant expertise that we've spent entire careers developing and making sacrifices for, is just not valued at all, on any level, by #UKRI and by the government.

So much depressing news for UK science #funding at the moment; jobs lost, opportunities for future postdoc career development going up in smoke.

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...

Significant cuts could damage the foundations of UK research - CaSE CaSE’s response to a letter sent by Science and Technology Facilities Council (STFC) Executive Chair Professor Michele Dougherty detailing major cuts to research funding.

CaSE: “UKRI need to explain how the cuts detailed in this letter are consistent with the commitment to protect curiosity-led research […]

“The information we have had so far is a failure in communication and transparency”

www.sciencecampaign.org.uk/press/detail...

Quite timely that Sir Ian Chapman, UKRI CEO, will be in front of the House of Commons Science, Innovation and Technology Committee on Tuesday next week… 👀

‘Grave’ concerns over applicant-led funds at UK research councils - Research Professional News Figures suggest reductions at MRC and BBSRC, with questions hanging over pending MRC grant applications

Full story by @isaacbarbosa1.bsky.social and me in today's Research Fortnight

www.researchprofessionalnews.com/rr-news-uk-r...

R for Biochemists 101 2 Feb 2026 Register online

Launching soon! R for Biochemists 101 begins on Monday 2 February 2026. Don’t miss your chance to boost your data skills and gain confidence in R. 🧪Secure your place today: https://ow.ly/f48R50XZXh2

I'm not a #cryoET person, but what it's capable of now is incredible!

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

RNA polymerase II coordinates histone deacetylation at active promoters Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.

This is a super resource - looking forward to having a good poke around

Awesome work looking inside #RNA structural ensembles during folding- congrats!

Sequential verification of transcription by Integrator and Restrictor Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...

I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!).
www.cell.com/molecular-ce...

This is super cool!

Enhancer-promoter compatibility is mediated by the promoter-proximal region Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...

What is a promoter? And how does it work?

We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters

www.biorxiv.org/content/10.1...

Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....

Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates

Will do- thanks!!

This looks super useful!

Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation