Endika Haro

Very happy to share that I just published a new paper from my thesis! 🎉

We analysed 546 species of ant to understand how extreme specialisation into reproductive and non-reproductive roles evolved. 

Key discoveries in thread🧵 👇

Full paper here: academic.oup.com/evolut/advan...

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

We are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!

It's always special when you find your own paper in the table of contents of the journal 😍

"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form

www.cell.com/developmenta...

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube Zhang et al. identify a global temporal chromatin program that operates across the developing vertebrate nervous system to control neural cell diversity. This mechanism, which involves Nr6a1 and NFIA/...

Good to see the peer reviewed version of this in print

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity

www.cell.com/developmenta...

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

Interested in gene regulation during development? Don’t miss the opportunity!

We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇

MLL2 facilitates long-range gene regulation through LINE1 elements Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...

#Preprint alert! 📣

We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements

www.biorxiv.org/cgi/content/...

as nice as always! 😉

Thank you Joaquina!!

This work would not have been possible without the support of @ibbtec.bsky.social @csic.es @erc.europa.eu @ageinves.bsky.social @ec.europa.eu

Pioneering work ! A must read!! Congrats!!!

Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator ZIC2, a member of the Zinc Finger of the Cerebellum family of transcription factors (TFs), plays crucial roles during neural development. In humans, defects in ZIC2 cause holoprosencephaly, a congenit...

📕Read the full preprint here: www.biorxiv.org/content/10.1...
Special thanks to my great PI and to the @radaiglesiaslab.bsky.social members at IBBTEC, specially to @sanchezgaya.bsky.social, whose work on the bioinformatics part of the project has been truly instrumental 💻📊📉⚡

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social

www.cell.com/cell/fulltex...

Part 1 and 2 of the Long-read sequencing Special Issues are now live! tinyurl.com/Genome-Res-LRS

Do et al., 2025. Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation www.cell.com/cell-genomic...

Predictable Engineering of Signal-Dependent Cis-Regulatory Elements

Excited to share my latest work with @joadelas.bsky.social and @jamesbriscoe.bsky.social

Predictable Engineering of Signal-Dependent Cis-Regulatory Elements

www.biorxiv.org/content/10.1...
1/11

Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)!

meetings.embo.org/event/25-enh...

Enhancer Mechanics and Enhanceropathies Join us for the highly anticipated third EMBO workshop on Enhancer Mechanics and Enhanceropathies! Building on the success of our previous meetings in Santander (2021) and Marseilles (2023), this eve…

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21).

Book the dates and register soon!!!

meetings.embo.org/event/25-enh...

ReproductiveRights.Gov Vanished, So We Brought It Back theSkimm makes it easier to live smarter. You're welcome. Get all the info you need from AM to PM, wherever you are.

The administration took down the reproductive rights website that women need access to. So The Skimm bought a url and brought the content back. Pass this on!

Go to reproductiverightsdotgov.com

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

Fulfilling a family tradition the day before Christmas. Hike to la Picota #Cantabria

Finally! The Hydroxychloroquine study by Gautret et al. has been retracted. I wrote a critical post about it in March 2020, days after it came out.

scienceintegritydigest.com/2020/03/24/t...