Rhys Allan's Avatar

Rhys Allan

@rhyscienceallan.bsky.social

Scientist at WEHI research, fascinated by the DNA circuitry of the immune system https://www.wehi.edu.au/researcher/rhys-allan/

875 Followers  |  292 Following  |  40 Posts  |  Joined: 15.11.2024  |  1.7051

Latest posts by rhyscienceallan.bsky.social on Bluesky


Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week.
Dont miss out on this opportunity ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➑️Unique opportunity ! 15 exiting days βž• Daily high profile lectures.
πŸ‘‰ bit.ly/4oGDR8f

20.02.2026 10:34 β€” πŸ‘ 7    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
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Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - Nature Biotechnology Trimodal single-cell analysis reveals gene-regulatory architecture in complex tissues.

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

19.02.2026 16:40 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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Review: @stjude.bsky.social @cp-molcell.bsky.social
Density transitions in the regulation of transcription
www.cell.com/molecular-ce...

20.02.2026 03:10 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation:
www.sciencedirect.com/science/arti...

18.02.2026 22:03 β€” πŸ‘ 60    πŸ” 17    πŸ’¬ 1    πŸ“Œ 2
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That's a wrap for Lorne Genome 2026! Thanks to all the speakers for fascinating talks, poster presenters for hot of the press science, trade for making the experiments possible and of course all the attendees for great discussion. See you next year!

18.02.2026 22:23 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion - Nature Communications Exhaustion is a functional state that hampers anti-cancer and antiviral CD8 T cell activity, and is preceded by a stem-like state, maintained by the transcription factor TCF1. Here authors develop mou...

TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards?

We setup a CRISPR KI system to ask this question, and the answer was unexpected.

www.nature.com/articles/s41...

18.02.2026 11:51 β€” πŸ‘ 19    πŸ” 7    πŸ’¬ 2    πŸ“Œ 0
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Congratulations to winners of the Lorne Genome Best Student Poster Prizes: Jessica Hawes, Sarah Berent, David Neville, Sandeep Kum and Andrea Daner!

18.02.2026 10:23 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Last day of #Lornegenome. A great venue, cool talks and discussions. Learnt about diversification of mammalian genomes, inheritance of mutations and impact of mutagens, how TFs direct chromatin organisation and so much more. New collaborations, new projects, can’t wait til next year

17.02.2026 21:47 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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2026 Winner of the Lorne Genome Julian Wells Medal: Christine Wells (no relation!) @stemcellsystems.bsky.social congratulations, well deserved!!

18.02.2026 00:18 β€” πŸ‘ 13    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

Hi yes I will have more to say about this in a few hours but please enjoy this paper. It's been a huge labour of love and effort for the last four years, and a significant part of our research efforts, and I'm so so so thrilled it's finally ready to share.

Tldr: scRNA-seq in Indonesia hard but fun

16.02.2026 07:43 β€” πŸ‘ 18    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0

So excited to have this study live! Lead by @ee-reh-neh.bsky.social's teram and in collaboration with an incredible team at MRIN in Indonesia. This is the culmination of ~5 years of work including a ton of effort in the field. Really proud of how this came together!

www.biorxiv.org/content/10.6...

17.02.2026 16:34 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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We’ve been spoiled with lovely weather & quality science at @lornegenome.bsky.social this year, continuing this morning with Session 11 (Novel Approaches to Study the Genome) & then the Julian Wells Medallist presentation. Hope everyone has rested up after the dinner! See you 9am! #LorneGenome2026

17.02.2026 21:07 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation @natgenet.nature.com @tessapopay.bsky.social @jessedixon.bsky.social @salkinstitute.bsky.social
www.nature.com/articles/s41...

16.02.2026 19:20 β€” πŸ‘ 0    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Lorne Genome Conference dinner with a few party crashers

17.02.2026 08:33 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Alex Hewitt @utas.edu.au takes #lornegenome through genetic drivers of glaucoma, making use of large biobanks, showing high predictive rates for glaucoma polygenic risk scores compared to other common diseases.

15.02.2026 22:57 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Choose your own adventure @lornegenome.bsky.social Duncan Odom www.lifepi-hd.com/duncan-odom asks if we want greatest hits or new hot stuff - role on hot stuff!

15.02.2026 22:09 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Duncan Odom takes #lornegenome on a wild ride through lesion segregation showing repair of DNA damage can be strand resolved.

15.02.2026 22:30 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Good morning @lornegenome.bsky.social delegates! In case you missed watching the sunrise on the beach this morning (with galahs!), I’m happy to report that today we have a forecast of blue skies, highs of 31 degrees & some great science, kicking off with @odomlab.bsky.social at 9am. #LorneGenome2026

15.02.2026 20:47 β€” πŸ‘ 29    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Alex Hewitt @utas.edu.au speaking about spatial transcriptome analysis of glaucoma @lornegenome.bsky.social @biorxivpreprint.bsky.social doi.org/10.1101/2025...

15.02.2026 22:41 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Up now @hannah-coughlan.bsky.social Hannah Coughlan of @wehi-research.bsky.social #Lornegenome Millenium Prize Winner talking about her work on the 3D organisation of the genome in immune cells

15.02.2026 06:45 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 1    πŸ“Œ 1

Vanessa Hayes taking us through African genetic diversity - a bottleneck was caused when populations migrated out of Africa, but sequencing efforts have focused on European and American genomes, leaving Southern Africa under-represented, causing a knowledge gap for diseases affecting African pops.

15.02.2026 05:39 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

We are welcoming Elizabeth Murchison @lizmurison.bsky.social back to Australia to talk about local scourge, transmissible tassie devil cancer, causing facial tumours that threaten survival of the species

15.02.2026 04:56 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0

Lorne Genome 2026 @lornegenome.bsky.social kicking off with the e-for-evil/e-for-effector pathogen ORF screen @miketilapia.bsky.social - preprint @biorxiv-immuno.bsky.social doi.org/10.1101/2025...

15.02.2026 03:12 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Welcome to Lorne for Lorne Genome Conference 2026! #lornegenome

15.02.2026 02:27 β€” πŸ‘ 10    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Next up @lornegenome.bsky.social 2026 is Jose Polo! He’s going to tell us about an unpublished study! 🀫 Luck us! #lornegenome

15.02.2026 03:37 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Exciting start to @lornegenome.bsky.social 2026 with Mikko Taipale! #lornegenome

15.02.2026 03:07 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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If I must .. @lornegenome.bsky.social

15.02.2026 01:38 β€” πŸ‘ 12    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Just two days to go! We are delighted to welcome 𝐏𝐫𝐨𝐟 𝐊𝐞𝐒𝐭𝐑 𝐒π₯𝐨𝐭𝐀𝐒𝐧, whose research explores transposable elements in plant genomes and harnesses them as genome engineering tools for crop improvement: https://www.lornegenome.org/keith-slotkin

13.02.2026 09:43 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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We are excited to hear from 𝐏𝐫𝐨𝐟 𝐌𝐚𝐭𝐭𝐑𝐞𝐰 π’π­πžπ©π‘πžπ§π¬, whose laboratory develops statistical methods&tools for population genetics and genetic association studies, including PHASE for haplotype inference and GEMMA for association testing: https://www.lornegenome.org/matthew-stephens

13.02.2026 09:52 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Interested in transcriptional regulation, enhancers and 3D genome folding?

In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control

www.biorxiv.org/content/10.6...

detailed πŸ§΅πŸ‘‡

12.02.2026 21:39 β€” πŸ‘ 67    πŸ” 33    πŸ’¬ 1    πŸ“Œ 3

@rhyscienceallan is following 20 prominent accounts