Di Jiang

@science.org Perspective - A tighter grip on gene expression | Science www.science.org/doi/10.1126/...
@nemcko.bsky.social + Alex Stark

@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.

❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX

@science.org Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome | Science www.science.org/doi/10.1126/...
#ribosome #RNA #hydrolysis

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop

❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky

🐦🦃🦉🦆🦢🦅🦜🕊️🐔🐤🦚🐥I like this week's cover @science.org
Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/...
#Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems

CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...

🧬@science.org CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade | Science www.science.org/doi/10.1126/... @chowdhurylab.bsky.social @michelleswift.bsky.social + al.
#DNARepair

ASB7 is a negative regulator of H3K9me3 homeostasis The maintenance of H3K9me3 involves the recognition of pre-existing modifications by HP1, which recruits methyltransferase SUV39H1 to methylate the adjacent newly incorporated histones, thereby establ...

🧬@science.org ASB7 is a negative regulator of H3K9me3 homeostasis | Science www.science.org/doi/10.1126/...
#epigenetics #chromatin #genetics #histone

Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion i...

@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

A nuclear house divided Certain fungal plant pathogens maintain varying chromosome distributions across multiple nuclei

Perspective @science.org A nuclear house divided | Science www.science.org/doi/10.1126/...

🔬🧬🍄 @science.org Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
@ubcbotany.bsky.social
#fungi #fungisky #mycology #genetics #chromosome #nucleus #DNA #evolution #genome #biodiversity

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

🧫🦠🔬🧬 @science.org Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems | Science www.science.org/doi/10.1126/...
@baptistedarracq.bsky.social @eloilittner.bsky.social @celineloot.bsky.social @epcrocha.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky

Mobile integrons encode phage defense systems Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

🧫🦠🔬🧬 @science.org Mobile integrons encode phage defense systems | Science www.science.org/doi/10.1126/...
@jaescudero.bsky.social @albertohca.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky

there is a podcast about #phage, but not a phage emoji
#PhageSky #virology #microbiology

thank you

so they have a very history of fighting against each other. they have evolved many strategies to do it. some of them, the molecular mechanisms, are unknown to science. this is one of them

it’s not about vaccines. it’s about how some bacteria defend themselves against viral infection. bacteria and viruses that infect them (they are called phages) have been around a long time before they were animals and plants,

🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9

🐛🕷️🕸️ @science.org Hawaiian caterpillar patrols spiderwebs camouflaged in insect prey’s body parts | Science www.science.org/doi/10.1126/... #entomology

🧬🦠🧫 @science.org RNA-mediated CRISPR-Cas13 inhibition through crRNA structural mimicry | Science www.science.org/doi/10.1126/... meeskelab.org bit.ly/sustecheducnJiaLab #CRISPR #RNA

Structural basis for nucleolin recognition of MYC promoter G-quadruplex The MYC oncogene promoter G-quadruplex (MycG4) regulates transcription and is a prevalent G4 locus in immortal cells. Nucleolin, a major MycG4-binding protein, exhibits greater affinity for MycG4 than...

🧬@science.org Structural basis for nucleolin recognition of MYC promoter G-quadruplex | Science www.science.org/doi/10.1126/...
@cancer-inst-purdue.bsky.social danzhou-yang.com #DNA #StructuralBiology

🧬 @science.org Rules of engagement for condensins and cohesins guide mitotic chromosome formation | Science www.science.org/doi/10.1126/...
@edinburgh-uni.bsky.social @golobor.bsky.social @imbavienna.bsky.social @jobdekker.bsky.social @umasspress.bsky.social @hhmi.org @mitofficial.bsky.social et al.

🩸 @science.org Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes | Science www.science.org/doi/10.1126/...
@bostonchildrens.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @hhmi.org @broadinstitute.org

Exogenous RNA surveillance by proton-sensing TRIM25 Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

🧬 @science.org Exogenous RNA surveillance by proton-sensing TRIM25 | Science www.science.org/doi/10.1126/...

🦠🧫 @science.org Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response | Science www.science.org/doi/10.1126/...
@christianfbaca.bsky.social @rockefelleruniv.bsky.social @hhmi.org @mskcancercenter.bsky.social

🧬 @science.org Structural insights into chromatin remodeling by ISWI during active ATP hydrolysis | Science www.science.org/doi/10.1126/...