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Frank Garcea

@frankgarcea.bsky.social

| Cognitive neuroscience professor | studying vision, language, skilled action, and the brain | https://www.urmc.rochester.edu/labs/garcea

25 Followers  |  27 Following  |  12 Posts  |  Joined: 31.03.2025  |  1.6781

Latest posts by frankgarcea.bsky.social on Bluesky

Check out Will Burns’ latest manuscript using fMRI and lesion-symptom mapping to study motor networks involved in speech and melody!

09.06.2025 03:29 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Forgot to include the figure!

04.06.2025 23:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Lots to unpack here! DM me if you’re interested in chatting about parietal areas involved in object use, category-specificity in the ventral stream, diaschisis, and lesion-symptom mapping! 8/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We show that the descending portion of the left arcuate fasciculus connects parietal action areas with object representations in the ventral stream. We propose that structural connectivity outside the ventral stream shapes category-specificity within the ventral stream. 7/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

(3) Weaker responses to tools in the ventral stream was linked to reduced fiber tract integrity of the descending portion of the left arcuate fasciculus. (4) FA of the left arcuate was not related to the strength of famous place responses in the ventral stream. 6/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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4 cool findings: (1) lesions to left parietal areas involved in grasping and object use were associated with weaker responses to tools in the ventral stream. (2) lesions to these parietal areas had no effect upon responses to famous places in those same ventral stream voxels. 5/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We call this method voxel-based lesion activity mapping (VLAM). 4/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We then drew each participant’s lesion mask using a high-res T1 image and warped the mask to MNI space. Next, we performed a lesion-symptom mapping analysis where the β€œsymptom” was the strength of responses for tools in the ventral stream. 3/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We recruited over 100 participants with brain lesions in the pre-op phase of their neurosurgical care. They all took part in category localizer fMRI task. We localized tool-preferring voxels in the left medial fusiform gyrus and adjacent cortex (undamaged areas). 2/8

04.06.2025 18:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Super excited to share this paper! We show that lesions to parietal areas involved in skilled action disrupt processing of tools in the ventral stream. 1/8

04.06.2025 18:32 β€” πŸ‘ 12    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Though it was a tough week with unfortunate news and events, it was also a great week supporting my students and their research!

05.04.2025 13:23 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Interested in semantic memory, lesion-symptom mapping, and word production? Check out our lab’s posters this afternoon from 230-430 pm! #CNS2025

31.03.2025 13:31 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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