PessoaBrain

A central finding is that the mapping from circuit structure to neural manifold dynamics is degenerate (so distinct circuit topologies can produce equivalent latent dynamics) but that circuit structure nonetheless constrains the topology of neuronal embeddings in the similarity space.

𝗪𝗵𝗮𝘁'𝘀 𝘁𝗵𝗲 𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻𝘀𝗵𝗶𝗽 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗺𝗮𝗻𝗶𝗳𝗼𝗹𝗱𝘀 𝗮𝗻𝗱 𝗿𝗲𝗰𝘂𝗿𝗿𝗲𝗻𝘁 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻?
This looks like a must read (suppl material bursting with goodies).
#neuroskeyence
doi.org/10.1016/j.ne...

𝗗𝘆𝗻𝗮𝗺𝗶𝗰𝗮𝗹 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝗮𝗻𝗱 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆
Another mega paper that deserves close attention.
Lots of implications, including emergence and evolution
iopscience.iop.org/article/10.1...
#complexity

I've been testing Claude to see how well it can "vibe out" a stat. power app that I've already coded completely myself - so I know what I want. It mostly gets things right with animations (those are easily verifiable) but looking into the backend stats code is nightmare inducing (see pic).

The Dream of the Butterfly

𝗪𝗵𝗮𝘁 𝗶𝘀 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝗮𝗹 𝘀𝘆𝘀𝘁𝗲𝗺𝘀?
Interesting paper tackling this difficult question.
Answer (in part): it's complicated!
The same fixed system can be interpreted as implementing many (even infinitely many) computations depending on the chosen decoding map.
doi.org/10.1088/2632...

𝗔𝘁𝘁𝗿𝗮𝗰𝘁𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻
Looks like a very cool paper about the dynamics of large-scale networks in the mouse brain.
Starting to be all about dynamics!
journals.plos.org/ploscompbiol...
#neuroskyence

Should biology put complexity first? The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing dama…

Should biology put complexity first? www.sciencedirect.com/science/arti... - excellent essay by @philipcball.bsky.social. I would add epistasis to polygenicity and pleiotropy as a ubiquitous and fundamental phenomenon, not some optional complication that we can try to account for afterwards

🤗

That's basically my point in that piece I wrote, but didn't address genetics directly

Interesting. What if the landscape is "too wobbly" , keeps moving around?? 😅
But I'll definitely take a look

Amazing

I reviewed 5+ fMRI papers on response inhibition within roughly the last year, and the same points come up over and over again. So I wrote a short note last week entitled "The unique limitations of BOLD-fMRI in the study of response inhibition". You can read it here.
osf.io/preprints/ps...

That's really too bad and "wrong" for BBS to demand so, imho.

𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲-𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮𝗻𝗱 𝗥𝗡𝗡𝘀
Interesting paper looking at "spatially embedded" recurrent networks and function.
www.biorxiv.org/content/10.6...
#neuroskyence

ah, will check that option

It's the abyss...

Undergrad level right?? Will definitely take a look but at a state university not sure I can use it at $140... 😬

For sure the forum if not elsewhere!

make it stop!! 😲

Worse even.
I *very* often bump into narratives about Brain This or That and after pages it becomes apparent that it's all about behavior/mind (eg education?). Journalists and authors need to find ways to show behavior in attractive ways. A colorful MRI image should not be necessary!

Brain death?? 😅
Haven't read it yet...

makes sense, amazing

Share the prompt!

𝗕𝗿𝗮𝗶𝗻 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴 𝗶𝘀 𝗿𝗲𝗺𝗮𝗿𝗸𝗮𝗯𝗹𝘆 𝗰𝗼𝗻𝘁𝗲𝘅𝘁 𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁
Circuits and networks can shift "computations" quite dramatically.
Check this computational model of the role of neuromodulators.
#neuroskyence
doi.org/10.1162/Neco...

🚨 New Paper from UP NExT (Univ. Pitt NeuralEngineering Cross-Translation): We discovered that microglia the brain’s immune cells, aren't just a "cleanup crew". During brain stimulation, they act as hidden neural modulators, actively monitoring and contacting neurons to help manage circuit stability.

What should I read please?

I'm very much enjoying it!

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗴𝗿𝗼𝘄𝘁𝗵
Beyond Kuhn and Feyerbend.
Still in chapter 2 but this looks great.

𝗧𝗿𝗮𝘃𝗲𝗹𝗶𝗻𝗴 𝘄𝗮𝘃𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻
"Cortical traveling waves in time and space: Physics, physiology, and psychology" is going to the top of the list!
doi.org/10.1016/j.ne...
#neuroskyence