Alex Tonks

Great news - well done

Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).

Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊

Couldn't recommend this PhD highly enough! Go join an exciting new young PI doing some super interesting/translational leukaemia research.

Health and Care Research Wales announces major £49m investment in research infrastructure Health and Care Research Wales announces major £49m investment in research infrastructure

Fantastic to see significant investment in health and social care research in Wales. Excited & proud to co-lead a new £3M Wales Applied Virology Unit with @richstanton.bsky.social and David Gillespie
- impactful research ahead #Virology #Unit #Research
healthandcareresearchwales.org/about/news/m...

Congratulations

Early-career researchers describe how they juggled workloads, emotions and finances after having children. Todays issue of Nature 🧪

Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York on FindAPhD.com PhD Project - Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York, listed on FindAPhD.com

Please share our new PhD position:
We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs.
This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools.

tinyurl.com/6rfan796

tinyurl.com/fmys7cay

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports imageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory macrophage polarization. This study shows that respiratory inhibition is not required for macropha...

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports

www.embopress.org/doi/full/10....

We are hiring a post-doc to study SUMOylation in leukemias @igmm-montpel.bsky.social
Apply here: emploi.cnrs.fr/Offres/CDD/U...

This is the most accessible explanation I have ever read on FDR. 👏👏 👏

Chatomics! Testing 10,000 genes at once? 🧬 If you’re relying on p-values alone, you’re probably drowning in false positives. Let’s talk about FDR and q-values—the smarter way to analyze your results.

Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...

Announcement 📣 REGISTRATION IS LIVE!! If you plan to join us in Cardiff for #IAMXVI then do register ASAP as places are limited! Do note the early bird deadline is 1 Feb! See you in #Cardiff in July #virology #adenovirus #meeting

www.eventsforce.net/cbs/frontend...

Check out our new review in @isehsociety.bsky.social journal Experimental Hematology, asking the question: to what degree is HSC dysfunction responsible for hematologic aging www.exphem.org/article/S030...

The strategy of the European Cancer Stem Cell Research Institute is to translate our cutting-edge research into novel therapies. We welcome the opportunity to host academic and clinical researchers whose interests align with the focus of ECSCRI.

We are hiring!!

We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy

eur03.safelinks.protection.outlook.com?url=https%3A...

EHA Research Conference 2025 Dates: March 17-20, 2025Location: Málaga, SpainChairs: Alba Maiques Diaz, Ruud Delwel, Panagiotis Ntziachristos, Marcus Buschbeck, Mark Dawson, Özgen Deniz, Kimberly Stegmaier, and Nina Cabezas Wallsc...

Two upcoming meetings for your 2025 diaries:

EHA Research Conference (ReCon) - Malaga 17-20 March
ehaweb.org/meetings/eha...

@isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025

and for HSC biologists in Europe...hold November 13-15th 2025 too.... !

Great opportunity here 👇 if looking for a PhD project in great lab

We are one of just 7 UK cancer centres that are contributing to the CRUK Black Leaders in Cancer PhD Scholarship Programme. We have 10 exciting projects on offer to eligible candidates of Black heritage backgrounds. Read more about the scheme and what we have on offer www.ncl.ac.uk/cancer/train...

Introducing my Generation Z students to the save button in reality! You don’t want to know what they thought the 5.25 disk was

A student of mine was very concerned by a news report saying the relative risk of a particular type of brain cancer had gone up by 50% When I looked at the absolute risk it went from 4 to 6 per 100,000. Told him not to worry. People have trouble dealing with absolute v relative risk!🧪

Molecular Basis and Mechanisms of Therapy Personalisation in Paediatric Leukaemia Only in the last decade have clinicians in India, with support from colleagues from the west, organized to develop multi-centre modern protocols for children with acute leukaemia. These protocols inc…

Registration and abstract submission is now open for this EMBO Childhood Leukaemia workshop that I am excited to help organise. See you in Kolkata!!

The use and impact of Twitter at medical conferences: Best practices and Twitter etiquette - PubMed The use of social media, and in particular, Twitter, for professional use among healthcare providers is rapidly increasing across the world. One medical subspecialty that is leading the integration of...

At #ASH24, sharing this terrific article on social media at medical conferences from @mtmdphd.bsky.social @rubenmesamd.bsky.social @bldcancerdoc.bsky.social #NaveenPemmaraju👇👇👇

pubmed.ncbi.nlm.nih.gov/29153078/

Tonks lab Christmas party! Shuffle board and ice free curling. Well done Rosie squared and for slaying the boys. Thanks to Owen Hughes for organising

Glorious sunny morning discussing leukaemia and new therapies for AML for students at Bath University. Thanks to Zoe Burke for the invite. #AML #inspiringnextgen

First post on BSky and I'm going to use it to promote the outstanding line up of faculty that we've managed to put together for #ISEH2025 in Kumamoto, Japan (with more to come). Save the date: lots of space reserved in the program for you to present your exciting science! Link below.

Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology man leukemia, particularly highlighting work in leukemic stem cells (LSCs), where lipids were assessed directly as a metabolite. Recent findings Lipid metabolism is essential to support LSC functio...

Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology 🧪
journals.lww.com/co-hematolog...

Very excited to hosting Dr Sophie Kellaway from @uniofnottingham.bsky.social Medical School for the @sussexuni.bsky.social School of Life Sci Biochem & Biomed seminar this Fri 29th Nov. Her seminar will be on her research targeting transcriptional dysregulation in AML.

GDSC seminar room 14-15.00.

Ferroptosis—disease perils and therapeutic promise Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment

Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!

Atlas of the plasma proteome in health and disease in 53,026 adults A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers...

Atlas of the plasma proteome in health and disease in 53,026 adults 👩‍🔬🥼👨‍🔬🧪. #proteomics #proteome #plasma #MedSky 👇👇

www.cell.com/cell/fulltex...