Eliza James

Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome Introduction Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are relatively common and disabling multisystem disorders that share overlapping features, including post-infect...

Harvard researchers studied 143 Long COVID and 170 ME/CFS patients and found both groups showed nearly identical signs of brain blood flow issues, small nerve damage, and widespread autonomic failure.

journals.plos.org/plosone/arti...

Researchers in South Korea found that SARS-CoV-2 selectively disrupts the brain’s orexin system, leading to lasting cortical neuron damage.

Boosting orexin levels reversed this effect, revealing a possible root of Long COVID fatigue and brain fog.

www.biorxiv.org/content/10.6...

🎯🎯🎯👇

Episodic memory deficits and processes in post-COVID condition - European Archives of Psychiatry and Clinical Neuroscience Cognitive dysfunction is one of the most prevalent symptoms in patients with post-COVID condition (PCC) and episodic memory has been highlighted as one of the most impaired cognitive domains in these ...

At Hospital Clínico San Carlos, 157 patients with post-COVID condition showed impaired episodic memory across multiple tests.

Difficulties were found in learning, storing, and retrieving information, even with cues and recognition.

link.springer.com/article/10.1...

…and more mentions of people arming themselves & saying things is not heard before now. I wondered today if they know this and give a shit.

"A couple of very important studies out just in the last 24 hours confirming what we've been saying for years and years now: Covid infections affect your immune system *badly*. Here's a few things you may have missed in them." followed by a partial screenshot of the page for this article: Persistent attenuation of lymphocyte subsets after mass SARS-CoV-2 infection (Dec 5, 2025) https://www.sciencedirect.com/science/article/pii/S1201971225005090

🎯🧵by @1goodtern.bsky.social on XTwitter:

"A couple of very important studies out just in the last 24 hours confirming what we've been saying for years and years now: Covid infections affect your immune system *badly*.
Here's a few..."

Full 86-tweet 🧵 (86!!!)
threadreaderapp.com/thread/20126...

I saw this earlier on twatter & I think grok said it was ai. Someone seemed to be pushing the message from multiple ai fronts, as far as I saw on my feed.

USA:

Wasn't there an off-the-rails gathering of repub congress, w only a few who didn't attend? There were hints dropped of utter debauchery.

I keep wondering if this was a set up to keep R mouths closed...like, blackmail.

As so many suspect w other current high profile players at the moment.

I briefly saw a post w a link about changing Google settings due to the recent changes. I can't locate that now.

Can someone assist?

👉 COVID and the Brain’s Dopamine Buffer: What the Science Actually Shows Let me unpack what David is talking about here: 🔹 The locus coeruleus is a tiny brainstem structure that acts like the brain’s on/off switch for alertness, threat response, and sleep stages. 🔹 During REM sleep, it’s meant to switch off, so the brain can dream while the body stays still. This system relies heavily on dopamine to keep sleep, movement, and arousal properly separated.

🚨🧵by @michaelryan756 on XTwitter on Covid, dopamine, & the impact on our brains...

"🔹The locus coeruleus is a tiny brainstem structure that acts like the brain’s on/off switch for alertness, threat response, and sleep stages.
🔹During REM sleep..."

Full 🧵
threadreaderapp.com/thread/20070...

Gorgeous. Where was this?

Long COVID: Your rights at work | Access Press People who live with Long COVID and are trying to remain part of the workforce need to know their rights. […]

"A reasonable accommodation is any change in the workplace or in the way things are usually done that provides equal opportunities for those with disabilities" -

#CleanTheAir
#Unions #WakeUp
#PreventLongCOVID
#ThePandemicIsNotOver

Via @kim2112.bsky.social

accesspress.org/long-covid-y...

As a historian I know what the government does to people it does not want to care for. And as a disabled community member, I see how poverty accelerates community members towards preventable deaths.

From ☝️

"As a historian I know what the government does to people it does not want to care for. And as a disabled community member, I see how poverty accelerates community members towards preventable deaths."

Welcome to the USA.

Hey Jon Stewart, jokes about wearing masks aren't funny Critics of the Daily Show host say he's a hypocrite.

Wrote about how disappointing it is that Jon Stewart punched down on people masking at @motherjones.com, when people should mind their own business and leave mask wearers be. www.motherjones.com/politics/202...

Done w The Bulwark & Jon Stewart.

For folks who like to think they know things, your pompous arrogance & incredible ignorance is showing. Go pick up a scientific journal & keep up, you A-holes. No better than an anti-vaxer/MAGA here.

@timmiller.bsky.social
@weeklyshowpodcast.bsky.social

An extremely mild case of c19 disabled me. I have lost much. Ppl r so mean just bc I’m trying to protect the little I still have when I can actually get myself out to get to an MD appt r devastating. U just amplified that.

Done w all of u.

@weeklyshowpodcast.bsky.social
@timmiller.bsky.social

Good lord. :(

COVID really harmed me. I’ve lost so much…just from one very mild no-big-deal acute infection.

Was this recent?

Analysis of Bacterial Coinfections in Patients with Mild,... This study aimed to analyze the clinical features and infection status of COVID-19 patients with bacterial infections in Shaanxi Province. A...

Shaanxi’s Nuclear Industry 215 Hospital studied 2,000 COVID-19 patients and found at least 15% had bacterial coinfections.

In severe cases, nearly all infections were caused by drug-resistant K. pneumoniae or A. baumannii.

reference-global.com/article/10.3...

Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effects COVID-19 is associated with increased risks of neurological and psychiatric sequelae. Alternative polyadenylation (APA) is ubiquitous in human genes, resulting in mRNA diversity, and has been validate...

Xiamen University scientists analyzed brain tissue from COVID-19 patients and found that infection changes how brain cells process mRNA, disrupting genes tied to memory, cognition, and psychiatric disease.

journals.plos.org/plosone/arti...

Change in Fatigue over 15 months in people the Post-Covid Syndrome Objective The objective was to estimate unique patterns of change in fatigue in people with the Post-Covid Syndrome (PCS) over 15 months. Design/Subjects The Quebec Action for Post-COVID (QAPC) study...

McGill researchers followed 545 people with post-COVID syndrome for 15 months and found that severe fatigue stayed high in nearly half.

Only a small group improved. Milder fatigue tended to resolve, hinting at different underlying causes.

www.medrxiv.org/content/10.6...

Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue A major consequence of the COVID-19 pandemic has been the emergence of post-COVID syndrome (PCS), and more specifically, post-COVID fatigue (pCF), with an estimated prevalence of ∼2%. We previously sh...

Newcastle University studied 145 people with post-COVID fatigue and found those still fatigued after 200 days had worse symptoms, slower reactions, and signs of brain and muscle dysfunction.

Without recovery, neurophysiologic damage appears to build.

www.medrxiv.org/content/10.6...

Catch Up On 2025’s Top 5 Stories From Canada Medscape News Canada leverages the most-read Canadian stories in 2025 and makes a list of the five that generate the most interest and, in some cases, controversy.

Medscape: 'Catch Up On 2025’s Top 5 Stories From Canada'

5. Canadian Cardiologists Must Step Up Care for Long COVID

'This story reminds readers that long COVID is still very much a condition that needs and deserves to be treated...'

www.medscape.com/viewarticle/...

Image of a man with his hand to his face Chronic fatigue syndrome Kevin Famuyiro By Kevin Famuyiro Senior Content Strategist Contact Dec. 20, 2025 5:21 AM PT 16 min Click here to listen to this article Key Facts ME/CFS is characterized by Post-Exertional Malaise (PEM), where symptoms worsen after minimal activity. The condition is classified as a neurological disease often triggered by viral infections or immune dysfunction. Diagnosis is a process of exclusion, requiring a thorough medical exam to rule out mimickers.

Great to see this sympathetic overview article in the LA Times

www.latimes.com/doctors-scie...

It's long so many if not most patients probably won't agree with every sentence but overall gets across a lot sympathetically.

Note: it doesn't focus on any particular news

#MEcfs #CFS #PwME

What is this? And when?

Image of a rope being held together with by a tiny thread “Screaming Immune Activation”: Major Lipkin Study Finds ME/CFS Systems Folding Under the Stress A couple of major themes are present. Immune activation on a massive scale. Failures on multiple levels to provide the muscles with the necessary energy to exercise. Metabolic inflexibility that prevents the body from getting into “exercise mode”. A toxin and free radical-laden system that’s co-opting resources needed to deal with exertion. An extracellular matrix is under attack, but is unable to defend itself, and a variety of systems are so stressed that they fold when stressors show up. The really remarkable thing is that a coherent argument can be made that, like dominoes falling, virtually every one of the abnormalities cited above can be linked together. They may be the logical conclusion of an energy-depleted, toxin-overrun system. Read more here>>

“Screaming Immune Activation”: Major Lipkin Study Finds ME/CFS Systems Folding Under the Stress

www.healthrising.org/blog/2025/09...

Screenshot from AMMES December 2025 newsletter

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

Every breath you take: High concentration of breathable microplastics in indoor environments The widespread presence of microplastics (MPs) in the air and their potential impact on human health underscore the pressing need to develop robust me…

Ok so if no one cares about the airborne virus that infects the lining of your blood vessels and breaks basically every part of your body, maybe they'll be interested in cleaning the air because it's also full of microplastics (those little threads floating in a sunbeam aren't pixie dust).

SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin — Hye-Kyung Lee et al. Rodent study. "S1 treatment led to a marked decrease in the expression of GRIN2A, JPH3, SHANK1, and GRIA2, whereas concurrent metformin treatment restored these levels to control values, suggesting a protective effect against S1-induced synaptic alterations."

#SARSCoV2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin

dx.plos.org/10.1371/jour...

Screenshot from latest Science for ME weekly update

#LongCovid #COVIDBrain #NeuroPASC #Coronavirus
#COVID19 #COVID

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques — Tomas R Wiche Salinas et al. "the measurable neurocognitive changes were associated with systemic and nervous system perturbations, indicating a link between infection-induced inflammation and long-term neurological and behavioral outcomes."

From the US:

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques

www.researchsquare.com/article/rs-8...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #Coronavirus
#COVID19 #COVID