Reika Watanabe

CAPRI Docking

A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease: Cell www.cell.com/cell/fulltex...

What about VPN?

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...

Structural insights into Measles virus RNA synthesis: C protein-mediated regulation of replication-transcription switch and allosteric inhibition by ERDRP-0519 https://www.biorxiv.org/content/10.1101/2025.07.21.666041v1

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments pubmed.ncbi.nlm.nih.gov/40654968/ #cryoEM

Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes - Nature Biomedical Engineering A microfluidics- and electron-microscopy-based method enables the characterization of polyclonal antibody responses to infection and vaccination.

Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes

www.nature.com/articles/s41...

Segmenting cryo-electron tomography data: Extracting models from cellular landscapes Cryo-electron tomography provides an unprecedented view of cellular architecture, yet extracting meaningful biological insights remains challenging. S…

I have lots of opinions—but for your sake, I’ve limited them to segmentation in cryo-ET for this article 😉
www.sciencedirect.com/science/arti...

#teamtomo

Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…

I'm pleased to share our new review article on RNA virus replication and in situ cryo-EM!

I personally had a Master's student in virology or biophysics in mind as a possible reader, and would be interested in feedback from that kind of crowd.

www.sciencedirect.com/science/arti...

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

Yes🤩

A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!

www.sciencedirect.com/science/arti...

World’s premier cancer institute faces crippling cuts and chaos | CNN The Trump administration’s broadsides against scientific research have caused unprecedented upheaval at the National Cancer Institute, the storied federal government research hub that has spearheaded ...

World’s premier cancer institute faces crippling cuts and chaos www.cnn.com/2025/07/08/h...

I was involved in this project as an early stage master’s student in protein engineering and it sparked everything that came after 🙌

I’m incredibly grateful I got to work with the amazing supervisor @juliankompa.bsky.social and the rest of the team on such a cool project. Check it out!

Highly recommended
👇

Congratulations, Lea! @lea-dietrich.bsky.social Great way to start a new chapter of your scientific journey 😍😍 All the best🎊

The mechanistic basis of cargo selection during Golgi maturation The multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a cons...

This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport.

The mechanistic basis of cargo selection during Golgi maturation

Taylor, Zubkov, Ciazynska et al.

doi.org/10.1101/2025...

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaqu...

Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB.

In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. 🧵🔽

#TBsky #MicroSky #TB

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Interested in research infrastructures career?

The #ARISE2 Fellowship Programme might be right for you.
MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪

🗓️ Call opening: 30 June
www.embl.org/training/ari...

Scientists have plenty of other examples

SCHRIER: Have you ever treated measles?

RFK JR: No

SCHRIER: Well I have. Let me tell you how miserable these kids is. The great thing is there's a vaccine to prevent it ... they only work if you actually give them

Nature Awards Global Grants for Gut Health Grants for researchers investigating the gut microbiota and its role in human health.

Nature awards and Yakult have announced another round of 'Global Grants for Gut Health'. An excellent opportunity for gut microbiota researchers, at any career stage, to win $100,000 for a year to cover their interesting research!

#MicrobiomeSky #MicroSky

www.nature.com/immersive/gu...

Congratulations,Tom! A fantastic news🎊😍

What great work! Congratulations to all authors! You have a brilliant idea for sample preparation, thorough functional assays, elegant image processing, and beautiful movies illuminating the elaborate virus transcription process!

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

LSI scientist working with the Aquilos focused ion beam/scanning electron microscope

The LSI is hiring!
We are seeking a research specialist in #AI and #MachineLearning to support the labs of @shyamalm.bsky.social and Herman Fung.
This individual will help develop advanced computer vision workflows for #cryoET and automated adaptive microscopy.

careers.umich.edu/job_detail/2...