Chi-Min Ho

Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social

Seeing is believing-Plasmodium falciparum translation in action pubmed.ncbi.nlm.nih.gov/41202797/ #cryoEM

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Congrats Paul!! Excited to see this out! 🥳

Chemical propulsion of hemozoin crystal motion in malaria parasites | PNAS Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food v...

Thrilled our study on heme crystal motion in #malaria @parasitesrule.org is now published @pnas.org, support from NIH, @bwfund.bsky.social, @uofutahcihd.bsky.social, UofU 3i. With Fu and Bidone labs @price.utah.edu, @uofubiochem.bsky.social, @uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...

Congrats Misha, looks gorgeous! 🥳Can't wait to dig in 😍

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...

We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.

Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...

Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️

A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

When noncanonical olfaction is optimal | PNAS The early olfactory system is canonically described by a “one-receptor-to-one-neuron” model: each olfactory sensory neuron (OSN) expresses a single...

It was so fun to work on this with @gkocker.bsky.social and @clienkaemper.bsky.social! It is out @pnas.org
If you love olfaction and love math, this one is for you!
🦟👃🧮

When noncanonical olfaction is optimal | PNAS www.pnas.org/doi/10.1073/...

Congrats, Halil and Team! 🥳

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome.
www.nature.com/articles/s41...

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We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.

We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography

zenodo.org/records/1717...

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

Stopping Ribosomes in Action! SBGrid member Chi-Min Ho uses cryo-electron tomography to map malaria’s ribosomes at work.

Stopping Ribosomes in Action!: a publication highlight from @keandreyam.bsky.social featuring the lab of @cmholab.bsky.social of @columbiauniversity.bsky.social & colleagues.

Read more here: buff.ly/jWYKq7r

#SBGrid #CryoET

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

Thanks Judy! Hope to see you again at 3DEM GRC next year :)

Thank you Freddy!! Miss seeing you at BoP, I got used to hanging out every year! Hoping to attend BioMalPar next spring, so hopefully we get a chance to catch up then :)

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/...

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕

FREE ACCESS reprint link found here: findaresearcher.wehi.edu.au/tham

📱click on 🌎 and last link
💻 last link on the left hand side

#malaria #transmission #cryoEM #ScienceResearch

www.science.org/doi/10.1126/...

Thanks Neel!! 😊

Thanks Ahmad!! ❄️🔬

Thank you Reika!! ❄️🔬🦠

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug Nature Structural & Molecular Biology, Published online: 18 August 2025; doi:10.1038/s41594-025-01632-3Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.

New online: Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

National Institutes of Health v. American Public Health Association When political ideologies interfere with science, everyone loses.

Right now, the continuation of many restored NIH grants relies on the SCOTUS shadow docket. SCOTUS is not immune to pressure.
Also, if you are represented by one of the 14 R senators that called for the restoration of NIH grants, please write them a thank you. Good behavior should be rewarded.

Submit your method to our denoising challenge!!! 👍

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...