S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
14.11.2025 19:30 β π 0 π 1 π¬ 0 π 0
Extremely thankful to get the opportunity to present my work at the WIRM! #WIRM2025
21.03.2025 12:47 β π 4 π 1 π¬ 0 π 0
Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome
Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.
Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.
www.frontiersin.org/journals/imm...
17.02.2025 07:22 β π 14 π 5 π¬ 1 π 0
Tejedor Vaquero, Neuman et al. @gmagrilab.bsky.social demonstrate immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease. https://buff.ly/4jVJYV5
π In HostβMicrobe Interactions 2025 π https://buff.ly/40XMv8r
21.02.2025 18:20 β π 6 π 3 π¬ 0 π 0
McClure, @hepworth-lab.bsky.social, Konkel et al. outline a Th17-to-Tfh plasticity during #periodontitis that is protective and limits periodontal pathology. https://buff.ly/41fwVq4
π In HostβMicrobe Interactions 2025 π https://buff.ly/40XMv8r
18.02.2025 18:14 β π 8 π 4 π¬ 0 π 0
Our very own Laura Shuttleworth talked about her brilliant research last night at the @crick.ac.uk for Sofar Sounds, sharing the stage with musicians and poets, and bringing science closer to society.
06.02.2025 15:36 β π 5 π 1 π¬ 0 π 0
Yaaaay well done, congrats π₯³π₯³ Have fun in your postdoc βΊοΈ
27.01.2025 09:48 β π 1 π 0 π¬ 0 π 0
Carers in STEMM: Caring Responsibilities
Are you a UK-based academic or student balancing your role as a caregiver with your research? We want to hear your lived experiences!
Are you a parent? Or caring for another adult, relative, friend? And are you a UK-based #academic? π§ͺ
We recently ran a survey (www.qualtrics.manchester.ac.uk/jfe/form/SV_...) to capture lived experiences - if you didn't complete the survey at the time, please do now. Please share w/ colleagues
15.01.2025 10:19 β π 3 π 8 π¬ 0 π 0
News at a glance: Oldest continuous ice core, formaldehyde's risks, and building Africa's science workforce
The latest in science and policy
Working in Antarctica, scientists have drilled the worldβs oldest continuous ice core, 2690 meters long and holding an unbroken history of the atmosphere going back 1.2 million years.
Learn more in this weekβs News at a glance. β¬οΈ
17.01.2025 17:07 β π 88 π 18 π¬ 0 π 3
Weβre thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) @jhumimmunity.org (https://buff.ly/3PAEMrK)! Groundbreaking, #OpenAccess research on #HumanImmunity π https://buff.ly/4ajqm8W
16.01.2025 16:00 β π 11 π 4 π¬ 1 π 4
Pathogens and planetary change - Nature Reviews Biodiversity
This Review explores the relationship between emerging infectious diseases and biodiversity loss, and how both are connected to global environmental changes in the Anthropocene.
There's a lot of replies to our new paper talking about how capitalism or overpopulation are the real enemy. Without getting into whether that's true of the climate emergency or the sixth mass extinction (π), I want to briefly explain why pandemics are different. www.nature.com/articles/s44...
16.01.2025 18:15 β π 54 π 29 π¬ 2 π 4
Earth breaches 1.5 Β°C climate limit for the first time: what does it mean?
The threshold has been exceeded for only one year so far, but humanity is nearing the end of what many thought was a βsafe zoneβ as climate change worsens.
Bad news for climate just announced! In 2024, Earth's average temperature temporarily exceeded 1.5Β°C above pre-industrial levels for the first time. This breach highlights accelerating climate risks - toward the end of the "safe zone" defined by the Paris Agreement.π§ͺππ
www.nature.com/articles/d41...
10.01.2025 20:08 β π 36 π 18 π¬ 0 π 1
Table graphic of the monthly global sea-ice extent from January 1979 through December 2024. Colours and cell numbers show the rank by month; blue shades (and higher numbers) show a larger ice extent, and red shades (and lower numbers) show a smaller extent.
Source: OSI SAF sea-ice index v2.2
Global sea-ice extent ranked by month from 1979 through 2024.
Nothing blue since since 2015!
Within the recent nine years, every month has experienced a record-low extent.
ππ§ͺβοΈπ
02.01.2025 07:33 β π 78 π 45 π¬ 3 π 6
AI Needs So Much Power, Itβs Making Yours Worse
Thereβs a strong link between proximity to AI data centers and higher levels of distorted power in residential areas
AI data centers are multiplying across the U.S. and sucking up huge amounts of power.
New evidence shows they may also be distorting the normal flow of electricity for millions of Americans
27.12.2024 20:30 β π 3025 π 1577 π¬ 94 π 277
Photo of the Vinuesa lab members by the sea.
Hi ππΌ The Vinuesa lab has arrived at BlueSky! Follow us if you want to talk about all the exciting science going on in autoimmunity, genetics, and anything B cell-related 𧬠π§ͺ
12.12.2024 19:58 β π 45 π 10 π¬ 2 π 0
Color blind friendly palettes for data visualizations with categories
A discussion of color blind friendly palettes for labeling unique catergories in data visualization.
Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication π§ͺ
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
08.12.2024 21:48 β π 835 π 354 π¬ 41 π 25
π"Pas de gegant per entendre la causa de l' #autisme mΓ©s comΓΊ"
π° @ara.cat
βοΈ @crisaez.bsky.social
β‘οΈ shorturl.at/1Dztj
#IRBScience #Autism @xsalvatella1.bsky.social
05.12.2024 08:53 β π 6 π 3 π¬ 0 π 0
go.bsky.app/7zMmwNY
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join π
20.11.2024 09:51 β π 64 π 30 π¬ 63 π 6
Periodic reminder: a lot of what makes AI "work" is exploited people doing the tasks, just hidden behind fancy websites.
It's good that a normie outlet like 60 Minutes is reporting on this.
23.11.2024 01:44 β π 1871 π 1022 π¬ 17 π 26
The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease, drug interactions, biomarkers
www.cell.com/cell/fulltex...
22.11.2024 18:05 β π 189 π 39 π¬ 4 π 8
Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....
19.11.2024 17:38 β π 37 π 14 π¬ 1 π 0
Enthusiastic, non-conformist researcher
π¦ Health Data Scientist & Project Manager @isglobal.org
π HIV Course Coordinator @lshtm.bsky.social
π§ PhD in Paediatrics @uct-fhs-research.bsky.social
π³οΈβπ They/Them
PhD student in the Arnold lab, University of Zurich. Fascinated about the immune system and what surrounds it!
Postdoc @The Francis Crick Institute | Homeostatic vs. autoreactive Bβ1 cell functions π§«π¬π¦ #B-1 cell #Science
Powrie Lab news and Mucosal Immunology content! Based at the Kennedy Institute of Rheumatology @kiroxford.bsky.social
Posts are by members of the Powrie Lab, not necessarily representative of the lab as a whole.
Post doc in the Arnold Lab, UZH. Former PhD of the Hepworth Lab, UoM. Fascinated in all things immunology.
Immunologist at University of Edinburgh working in B and T cells in infection (malaria) and autoimmunity (rheumatoid arthritis). I use NGS, computational biology, single cell approaches and Adaptive Immune Receptor Repertoire seqπ¨π»βπ»π§¬π¦ π§«
Principal investigator at the University of Edinburgh.
Research on the systemic immune response to stroke and complications of stroke recovery. #Bcells #infection #GIdysfunction #cognitivedecline
Wellcome Sir Henry Dale fellow
Neuroimaging data analyst with a background in biomedicine and neuropsychology. She/her π³οΈβπ
Immunologist at the University of Manchester | UKRI Future Leaders Fellow | Studying B cells in airway inflammation and autoimmunity | She/her
Group Leader & Reader in Mucosal Immunology studying intestinal cell interactions via complex organoid models (ILC, epithelium, stroma, neurons, microbiota) in IBD, Parkinson's Disease and food allergy.
Postdoctoral Researcher @witherslab.bsky.social at University of Oxford | Immuno-oncology
PhD student at the University of Manchester exploring whipworm biology using NanoSIMS (he/him)
Wellcome Trust PhD student at the University if Manchester. Studying chemokines, the glycocalyx, and Whipworm infection!
Associate professor at Penn studying X-chromosome Inactivation & sex differences in the immune system. She/her.
We study the human mucosal immune system with a focus on IBD and HIV to determine mechanisms of disease pathogenesis and predictors of therapeutic response
Journal of Human Immunity (JHI) is the official open access journal of the International Alliance for Primary Immunodeficiency Societies (IAPIDS). Published by @rupress.org π jhumimmunity.org
Postdoc fellow in the Stark Lab @ MIT. Researching the role of glycans in cancer immunology π¦
// previously University of Manchester
