Nicholas Mancuso

Isn't "completely made up shit" the defining feature of fiction

Spotify pls I beg u

Herb garden is all popped out! Plus the mantis is all grown up!

A tweet "Elon Musk thinks our new embryo screening startup, @herasight, is "cool". Cool." with a picture included in the tweet of a web widget showing an embryo selected for IQ.

A quote tweet of Cremieux a pseud who "tweets about race & genetics" see here for more background on Cremieux/Lasker: https://www.theguardian.com/us-news/2025/mar/03/natal-conference-austin-texas-eugenics Text reads: "The widget pictured below gives you the expected range of predicted IQs (or disease risks) for the number of embryos. The difference between the average and the highest gives you the expected gain in IQ if you were selecting the embryo with the highest predicted IQ. "

The startup named Herasightm after the goddess who threw her disabled child off a mountain, seems focused on public outreach using embryo selection for IQ to win over far rightwing pseuds & techbros

I have reached my peak online grumpiness.

I am getting ready to be Very Grumpy online

I've said it on X and ill say it again here. This shit sucks. Will they be held responsible if parents use this with weak predictors and their child still develops a disease? Weak prognostics aren't causal indicators!

Disappointed to see some folks who do good work involved at various levels.

Can't ever be wrong if they only ever predict risk. The perfect grift

Palestinian children have been killed at a rate of more than one child per hour during Israel's war in Gaza.

“A whole classroom of children killed every day for nearly two years,” UNICEF’s executive director said.

Here are some of their stories: wapo.st/3UCiAjn

YouTube video by therotatingchinmen Minnie Riperton - Les Fleurs

Channeling Les Fluer by Minnie Riperton each morning as I water the garden. youtu.be/g1kDd6yBQZ4?...

Smart is when smug living thesaurus

NIH wants to hear from you. No really.

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs
grants.nih.gov/grants/guide...

Alex Strudwick Young @AlexTISYoung · 3h The widget pictured below gives you the expected range of predicted IQs (or disease risks) for the number of embryos. The difference between the average and the highest gives you the expected gain in IQ if you were selecting the embryo with the highest predicted IQ. The spread does not depend on the mean you choose. The mean IQ you put in is actually the genotypic mean IQ of the parents (as we state) as we didn't want to get into the complexities of modeling regression to the mean in this widget, although we do of course model regression to the mean in our customer reports. We will be detailing rigorous validation of our IQ predictor in an upcoming publications, along with lots of other exciting science. -Quote tweeting the nazi Jordan Lasker (Cremieux) saying: "The latest embryo selection company is live, and guess what: They're publicly letting people select for IQ!"

New snake oil just dropped

And proudly boosting the nazi approval, bold business strategy!

If ~40yos are already BCa/PCa cancer survivors I don't think a PGS will screen better than looking for coding variation at BRCA--and if 50yo+ are doing IVF I worry that increased mutations ~might~ play a larger role than expected. But hey, I'm not after that sweet sweet VC and IQ money

I'll have to take a more careful look at their simulations and how risk was calculated, but at first glance it seems ~okay~. I think my primary issue is that so much of how these are being used are at odds with how it could work in practice.

I wonder if this is the best potential outcome, as little will likely be used for the implied domestic terror and the govt (when run by Ds at some point) can prosecute and seize funds

It isn't hard to see whats going on, but a quick glance can easily mislead. And in the days of non-informed folks looking online I can easily see this being misused/misinterpreted. But hey VCs need a slide show, right?

Siri, what is the mean incident age of BCa/PCa? Siri, what is the mean incident age for IVF screening?

Rake in more VC money with this one ez trick

Its a press release for another embryo screening company lol

Want to make a misleading figure with regression? Instead of orienting results around the identity line, just orient results around ur regression line, and things look great!

Bought this milkweed plant a few months back hoping it would attract monarch butterflies, and it looks like it was successful!

Senior White House officials intervened to scrap the OMB effort to halt funding to the NIH, reports @nidhisubs.bsky.social, who broke the story for the WSJ

bsky.app/profile/nidh...

Announcing 2025 Awardees

🚨Just Announced: The 2025 ASHG Professional Award Winners! Meet the innovators shaping the future of human genetics.

💥Full list & details: www.ashg.org/membership/a...
#ASHG #HumanGenetics

Me, weeks back: Ah, S2 intro theme for Dan Dan Dan isn't so good.
Me, now: must never skip S2 theme

The Python type hint 'Literal' should have been named 'Finite'. It is specifying a finite set of values that define the type!

Did…did I just…agree with my full chest…with these podcast bros??!!

ARE WE COMING FULL CIRCLE?!

Consequences will not be felt today, but 5 year, 10 years down the road, when you're diagnosed with cancer, and you need a new clinical trial to hop onto, or a new drug to let you watch your grandkids grow up, they won't exist. Why would anyone choose to side with cancer against humanity? 🧪