Nicholas Mancuso

Yoooo huge congratulations!

CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.

Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n

news.cuanschutz.edu/dbmi/cu-ansc...

For folks that have tried both codex (5.3-codex) and claude, what are your thoughts? I've been using codex with some success, but it seems very limited compared to the subagent and plugin capability that claude has.

I mean maybe. Also searing steaks and smashburgers--red meat consumption is a massive risk factor!

James Van Der Beek’s Death Underscores Early-Onset Colorectal Cancers The actor James Van Der Beek, who died on Wednesday at 48, was among a growing number of adults under 50 diagnosed with the disease.

The actor James Van Der Beek, who died on Wednesday at 48, was among a growing number of adults under 50 diagnosed with colorectal cancer. The disease is now the leading cause of cancer-related death in adults in this age group, surpassing lung and breast cancer.

teach me ur ways

GitHub - quattro/jax-numerics-agent: SKILLS.md definitions for JAX/Equinox based software development SKILLS.md definitions for JAX/Equinox based software development - quattro/jax-numerics-agent

This also relies on the jax and python-based CLI development I've provided here github.com/quattro/jax-... . Still lots of room for improvement in rules and contexts. Can't believe how quickly AI agents have improved.

GitHub - quattro/ed3d-plugins: Ed's repo of Claude Code plugins, centered around a research-plan-implement workflow. Only a tiny bit cursed. If you're lucky. Ed's repo of Claude Code plugins, centered around a research-plan-implement workflow. Only a tiny bit cursed. If you're lucky. - quattro/ed3d-plugins

The core AGENT logic is a barebones extension of @ed3d.net 's excellent claude plugins to work with codex github.com/quattro/ed3d.... This provided coded with a much richer feedback and planning system.

All in all, I spent about ~ few hours working on tasks, while codex was chugging in the background. I would check in every while to see where it was at, suggest improvements to either its code, or update skill rules. Its final implementation should numerically match, but still unimpressive wrt speed

GitHub - mancusolab/jax_ldsc Contribute to mancusolab/jax_ldsc development by creating an account on GitHub.

I used my JAX-based skills for codex to port the excellent Python3 LDSC spec to JAX and Polars.

My intent here was to stress test my JAX skill definitions and find how I could improve rules and contexts--NOT to develop a replacement github.com/mancusolab/j...

Any local attn model that operates on genotype rather than haplotypes will only find FPs imo. I'll take a look, but I just have a hard time intuiting how epistasis could act across haplotypes locally. Never say never I guess

a man says " and it has everything " in front of a world map ALT: a man says " and it has everything " in front of a world map

It's this, the show is this

Simple baseline always.

That blog series is deep lore. We need more pls Dan

Please for the love of god, let Yahya Abdul-Mateen II and Ben Kingsley do whatever roles they want together from here on out. Wonderman is brilliant

Trump is in the unredacted Epstein files "more than a million times," Raskin alleges One document recounts that Trump said he "never" asked Epstein to leave Mar-a-Lago.

Rep. Jamie Raskin tells Axios that when he searched Trump's name in the unredacted Epstein files, it came up "more than a million times." www.axios.com/2026/02/10/t...

GOT EEM

I think it's important that everyone in this chain of command hang.

Can you call a laplacian solver for Lx=1?

Another Claude project: a static site that pulls in GWAS SNP data from ensemble, multiple public biobanks, open targets, gtex, eqtl catalog, and OMIM.

sashagusev.github.io/gwas_lookup/

Birria sliders whew

The person Will is responding to literally has a profile pic mocking Will Stancil, whose "last account got banned"

These people are deranged! This is a level of brain poisoning similar to QAnon except it's targeted harassment of ONE person.

They should all be ip banned!

High treason.

A statement from Jeremy Berg thanking Stand Up for Science and the signers of the Bethesda Declaration and other statements of dissent from science agencies.

My response...

2/2

We are watching in real time who some scientists are willing to sacrifice in favor of access to funding: early career researchers, trainees, scientists from historically excluded groups and immigrants.

Interesting, but of course: "It’s worth noting that a C compiler is a near-ideal task for semi-autonomous AI model coding: The specification is decades old and well-defined, comprehensive test suites already exist, and there’s a known-good reference compiler to check against."

Preventing premature deaths through polygenic risk scores - Nature Communications Via an integrative modelling approach that combines population and clinical trial data, the authors find that polygenic risk score-based screening would reduce premature mortality across seven commonl...

Polygenic scores are useful for early detection, but also early prevention!
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...

Pour one out for every professional political pundit, writer, consultant whatever that has spent the last decade trying to pretend that the Trump phenomenon was about trade or opiates and not a big chunk of white america losing its mind over having a black president bsky.app/profile/kyle...

the dustbuster

nice congrats!