Nicholas Mancuso

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

So when I hear of students being encouraged to use GPT in college I don’t hear innovation. I hear cognitive atrophy, the inability to think critically for oneself, and total dependence on vulnerable centralized repositories of data for knowledge without ever understanding how knowledge is generated.

Just arrived this week direct from CSH. Looking forward to reading!

Epigenetics: History, Molecules, and Diseases Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders

My book on Epigenetics: History, Molecules and Diseases

www.amazon.com/Epigenetics-...

#EpigeneticsBook #Epigenetics

Will you be at #ASHG25 next week? Come chat each day 3-4pm at ASHG Central!

YES LFG

I finally made (it on) my first cover 🤣 🥳!!
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.

Please consider submitting your work in genetics/genomics with us!

Has Your Scientific Work Been Cut? We Want to Hear.

A new NYT as-told-to series, "Lost Science," documents the work of researchers who have lost their jobs or funding after cuts by the Trump administration. Share your story with us!

www.nytimes.com/2025/10/08/c...

Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference Visit our website to learn more.

PEQG website live! genetics-gsa.org/peqg-2026/

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Which bars, I need these bars

Tax incentives for folks who have children directly support those children bc, again, kids cannot work. Comparing children to owning property says more about you than any other weird links u try to dredge up

There was some standup that popped into my insta feed that was similar to this. "I wike peanut butter n beef. Wanna see my muscles?" Can't seem to find it, but the 6-year old voice sold it.

Inference of complex demographic history using composite likelihood based on whole-genome genealogies Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Method works from simple and complex scenarios in jointly estimating epoch time, population size, migration rate (symmetric or asymmetric), growth rate, and admixture proportion. Software integrated with msprime, demes, tsinfer/tsdate, relate, and singer. github.com/aprilweilab/...

Hey Tom, do children incur extra financial costs? Also, can children work? Thx.

Holy shit, AI can do my job after all. I work in retail and I lie to people all the time to make them stop bothering me.

Episode 27 - Frog in the Streets and a Freak in the Sheets Podcast Episode · Normal Men · 10/08/2025 · 1h 2m

New Normal Men! @golikehellmachine.com returns to tell us about Portland, we break down the shutdown, and @ed3d.net talks @rickywlmsbong.bsky.social into buying Hades 2.

The elimination of USAID is a moral atrocity and all involved made a choice to enable, and then lie about, ending the lives of some of the most vulnerable people in the world.

Right? The blog does an -excellent- job of walking through results.

Understanding Optimization in Deep Learning with Central Flows

This paper is bananas and shows there is still so much to be learned about gradient descent behavior. [ODEs are so hot right now]

centralflows.github.io

USC faculty members denounce Trump compact that would shift university to the right The USC Academic Senate held a special meeting to discuss the Trump administration's education compact, which was presented to the school last week.

Yesterday's Academic Senate meeting was amazing. Zoom was at capacity, and once I was finally able to join, I was met with a unified front and consistent message from faculty. We fully reject this compact!

I'm sure the board of trustees will recc the right decision

www.latimes.com/california/s...

Why This Essay Could Cause the University of Virginia to Shut Down How Linda McMahon’s latest “compact” would do deep and permanent harm to American higher education

I wrote about the “compact” for higher education

newrepublic.com/article/2013...

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Another possible topic is that we typically hire 1-2 postdocs per year. This year I'd like to add at least one person with functional genomics/single cell/perturb-seq interests, especially relating to immune cells. Our broader lab interests are in popgen and complex traits.

The NYC Bar has issued an opinion concluding that the Trump-ordered attacks on Venezuelan fishing boats constitute unlawful summary executions. This is a very big deal. And it explains why the DOD can't find lawyers to say the attacks are lawful. www.nycbar.org/press-releas...

Letter Regarding Compact MIT Chapter of the American Association of University Professors October 6, 2025 Statement on the “Compact for Academic Excellence in Higher Education” MIT has been invited by the federal governmen...

I am proud of MIT, where our branch of AAUP has voted unanimously to endorse this statement urging MIT leadership and the MIT Corporation to reject the Compact wholesale
docs.google.com/document/d/1...