Samuel BERTRAND

Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks–What about specialised metabolism? In recent years, genome sequencing of filamentous fungi has revealed a high proportion of specialised metabolites with growing pharmaceutical interest. However, detecting such metabolites through in s...

This is my second article in #SystemBiology applied to #NaturalProduct discovery with D. Nègre and A. Larhlimi. the first one was: "Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks–What about specialised metabolism?"
doi.org/10.1371/jour...

A Required Sensitivity Analysis for Predictive Reliability of Genome–Scale Metabolic Networks: Probing Biomass, Nutrient Conditions, and Specialised Metabolism With Penicillium rubens as a Case Study GSMN robustness through sensitivity analyses.

Happy to share my latest article in #SystemBiology: "A Required Sensitivity Analysis for Predictive Reliability of Genome–Scale Metabolic Networks: Probing Biomass, Nutrient Conditions, and Specialised Metabolism with #Penicillium rubens as a Case Study" #ProudPI
doi.org/10.1002/bit....

Coculture of Coastal Macroalga-Epiphytic Trichoderma Fungi for Microalgal Algicide Production Highlighted by an Iodinated Terpenoid Macro- and microalgae are primary producers in coastal ecosystems, and the former harbor diverse microbes. During our investigation of the fungi associated with estuarine macroalgae, Trichoderma spp. ...

Here is a interesting paper abour #MicrobialCoCulture: "Coculture of Coastal Macroalga-Epiphytic #Trichoderma Fungi for Microalgal Algicide Production Highlighted by an Iodinated Terpenoid" pubs.acs.org/doi/10.1021/...

Here is a new article about #MicrobialCoCulture: "Co-Culture of #Monascus purpureus and #Aspergillus niger Isolated from Wuyi Hongqu to Enhance Monascus Pigments Production While Inhibiting Citrinin Production" www.mdpi.com/3602796

Here is a new article about #MicrobialCoCulture: " “Hyphae Intertwined, Biomolecules Co-Born”—New Polyketides Induction by Co-Culture of the Mangrove Endophytic Fungus #Phomopsis asparagi DHS-48 and #Pestalotiopsis sp. HHL-101 at Both Volatile and Non-Volatile " www.mdpi.com/3606608

Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation Two novel macrolide hybrids, cladoescherins A and B (1 and 2), and a rare macrolide dimer, dithiocladospolide (3), were identified from cocultures of Cladosporium sp. and Escherichia coli. Compounds 1...

Here is a new article about #MicrobialCoCulture: "Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation" pubs.acs.org/doi/10.1021/...

Systematic sensitivity analyses of growth modelling to evaluate the robustness of Genome Scale Metabolic Network models — case study with the filamentous fungus Penicillium rubens The functionality—and thereby the quality—of a Genome Scale Metabolic Network (GSMN) model is commonly evaluated by using a biomass reaction as the objective function to determine flux distributions u...

Very happy to share the latest preprint from the #ANR: "Systematic sensitivity analyses of growth modelling to evaluate the robustness of Genome Scale Metabolic Network models — case study with the filamentous fungus Penicillium rubens" #ProudPI doi.org/10.1101/2025...

Therapeutic Efficacy and Drug Metabolism of Griseorhodin A Induced by a Co-culture of Actinomycete Strain TMPU-20A002 and Mycobacterium smegmatis in S … In screening for antibacterial agents from co-cultures of Mycobacterium smegmatis and microbial resources, such as actinomycetes and fungi, the known …

Here is a new artical about #MicrobialCoCUlture: "Therapeutic Efficacy and Drug Metabolism of Griseorhodin A Induced by a Co-culture of #Actinomycete Strain TMPU-20A002 and #Mycobacterium smegmatis in Silkworm Infection Models" doi.org/10.1248/cpb....

Metabolites Profiling and Bioactivity of Aspergillus-Penicillium Co-culture: Integrative GC-MS, LC-MS/MS, and in Silico Analysis for Targeting Fusarium Proliferatum in Onion Basal Rot Biocontrol - Che... Onion basal rot, caused mainly by the soil-borne fungus Fusarium proliferatum, is a serious and persistent disease affecting onion (Allium cepa L.) worldwide. It results in severe yield reductions, im...

Here is a new article about #MicrobialCoCulture: "Metabolites Profiling and Bioactivity of #Aspergillus-#Penicillium Co-culture: Integrative GC-MS, LC-MS/MS, and in Silico Analysis for Targeting #Fusarium Proliferatum in Onion Basal Rot Biocontrol" link.springer.com/article/10.1...

Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived Aspergillus sp. and Penicillium sp. Three new arthrichitin derivatives I–K (1–3) and three known congeners (4–6) were isolated from a coculture of mangrove-derived fungi Aspergillus sp. and Penicillium sp. using 1H NMR-guided fractionat...

Here is a new article about #MicrobialCoCulture: "Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived #Aspergillus sp. and #Penicillium sp." pubs.acs.org/doi/10.1021/...

Expanding the frontiers of microbial biosynthesis with synthetic microbial communities Advances in synthetic biology have extended microbial engineering to programmable microbial communities. Through rational pathway partitioning and wel…

A recent review about #MicrobialCoculture: "Expanding the frontiers of microbial biosynthesis with
synthetic microbial communities" www.sciencedirect.com/science/arti...

Host–Pathogen Interaction Activated Biosynthesis of Natural Products The way immune cells attack pathogenic microorganisms might trigger pathogens to produce compounds that promote their survival. Based on this idea, we constructed a coculture system of pathogenic fungi and immune cells and isolated fumigatinolactone (1) as a new natural product by coculture of Aspergillus fumigatus IFM 60237 with RAW264 mouse macrophage-like cells. Fumigatinolactone (1) was produced via a nonenzymatic coupling reaction between fumigatin (4) and a new type of intermediate fumarylazlactone (5). An investigation of the interaction mechanism between the fungi and cells revealed that the survival interaction between pathogen and immune cells played key roles. Surprisingly, fungi showed a response to nitric oxide (NO), which was produced by macrophages, resulting in the production of 4. In addition, an iron starvation condition triggered the production of 5. Finally, 1 was obtained by these two mechanisms. Furthermore, compounds 1–4, particularly 4, showed inhibition of NO production from RAW264, which might be a defense action for macrophage by fungi. This is the first example of elucidation of interaction mechanisms between pathogen and immune cells for activation of silent genes to produce a new compound. These findings suggest that host–pathogen survival interaction may increase the production of secondary metabolites from fungi.

Here is a new article about #CoCulture between fungal and mouse cells: "Host–Pathogen Interaction Activated Biosynthesis of Natural Products" pubs.acs.org/doi/10.1021/...

Bioactive Spirocyclic C‐Arylglycosides From the Fungal–Fungal Co‐Culture of Pestalotiopsis sp. and Nigrospora sp. Two new papulacandin analogs (1–2), together with 12 known compounds (3–14), were identified from the co-culture of two endophytic fungi, Pestalotiopsis sp. J025 and Nigrospora sp. Wn-2-2, isolated f...

here is a new article about #MicrobialCoCulture: "Bioactive Spirocyclic C-Arylglycosides From the Fungal-Fungal Co-Culture of #Pestalotiopsis sp. and #Nigrospora sp." doi.org/10.1002/pca....

Integrating multi-level approaches to assess blue mussel (Mytilus spp.) responses to short-term temperature and salinity changes Climate change is exacerbating temperature and salinity variations in marine ecosystems, thereby challenging the physiological resilience of bivalves …

Here is the latest article I was involved in. "Integrating multi-level approaches to assess blue mussel (Mytilus spp.) responses to short-term temperature and salinity changes" www.sciencedirect.com/science/arti...

Very happy to be part of this collaborative project ! Thanks for the team for the invitation !!!

Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset Annotation is the process of assigning features in mass spectrometry metabolomics data sets to putative chemical structures or “analytes.” The purpose of this study was to identify challenges in the a...

Hello! Check out our new publication led by @nadjacech.bsky.social and based on a collaborative effort!

pubs.acs.org/doi/10.1021/...

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor Sextonia rubra is a tropical tree endemic to the Guiana Shield and the Brazilian Amazon. Despite its renowned wood durability, it remains susceptible …

a recent article about #MicrobialCoCulture: "Reverse chemical ecology to study the defense of the plant host #Sextonia rubra and the chemical mediators of its endophyte #Fusarium falciforme against phytopathogen #Trametes versicolor" www.sciencedirect.com/science/arti...

📢 Appel à projets générique #AAPG 2025 : l’ANR publie les premières listes de projets sélectionnés dans le cadre de 21 comités d’évaluation.
➡ anr.fr/fr/actualite...

ATLASea débarque à la Station Marine d’Endoume ! Du 16 au 26 juin, la Station Marine d’Endoume accueille les équipes du projet ATLASea, un ambitieux programme européen pour percer les secrets de la biodiver...

🌊 Du 16 au 26 juin, ATLASea débarque à la Station Marine d'Endoume !

Regardez trois interviews en direct sur IMBETV ! 🎥 : urls.fr/OTyHZV
🔹 Jeudi 19 juin à 18h30
🔹 Lundi 23 juin à 18h30
🔹 Jeudi 26 juin à 18h30

🎤 Posez vos questions en ligne pour échanger directement avec nos chercheu-r(-se)s !

Co-culture of Cajanus cajan (Linn.) Millsp. cell suspension cultures with an endophytic fungus for the enhanced production of pharmacologically active cajaninstilbene acid - Plant Cell, Tissue and Org... Cajaninstilbene acid (CSA), a natural stilbene in Cajanus cajan (Linn.) Millsp., is highly appreciated for its remarkable bioactivities. This study aimed to enhance the CSA yield in C. cajan cell susp...

Here is new acticle about #CoCulture between plant cells and a fungus: "Co-culture of Cajanus cajan (Linn.) Millsp. cell suspension cultures with an endophytic fungus for the enhanced production of pharmacologically active cajaninstilbene acid" link.springer.com/article/10.1...

One recent article about #MicrobialCoCulture : "A New Azaphilone Derivative from the Co-culture of
#Aspergillus versicolor and #Aspergillus chevalieri" doi.org/10.25135/rnp...

Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans - Natural Products and Bioprospecting The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation ...

One new article about #MicrobialCoCulture: "Vibralactone derivatives isolated from co-cultures of the basidiomycetes #Stereum hirsutum and #Boreostereum vibrans" link.springer.com/article/10.1...

very happy to share the latest publication I was involved in : "An exploratory study of species richness and dynamics in the cultivable mycobiota of #Palmaria palmata" doi.org/10.1016/j.fu...

Steroidal Adducts and Andrastin-type Meroterpenoids from the Co-culture of Two Isodon Species-Associated Endophytic Fungi Thieme E-Books & E-Journals

here is a new article about #MicrobialCoCulture : "Steroidal Adducts and Andrastin-type Meroterpenoids from the Co-culture of Two Isodon Species-Associated Endophytic Fungi" www.thieme-connect.de/products/ejo...

A recent article about #MicrobialCoCulture: "Crepidamycins A–E, pyranonaphthoquinones from endophytic #Streptomyces sp. MG-F-1 of #Dendrobium crepidatum by the co-culture strategy" doi.org/10.1016/j.ph...

Assessment of the effects of cadmium, samarium and gadolinium on the blue mussel (Mytilus edulis): A biochemical, transcriptomic and metabolomic approach Improving the understanding of how chemicals affect on organisms and assessing the associated environmental risks is of major interest in environmenta…

First article of the year! « Assessment of the effects of cadmium, samarium and gadolinium on the blue mussel (Mytilus edulis): A biochemical, transcriptomic and metabolomic approach » www.sciencedirect.com/science/arti...

A great time with the rest of the board! Stay tuned for information on the new initiatives 🤙🏾

The #RFMF wishes you a fantastic 2025 filled with exciting discoveries, fruitful collaborations, and inspiring scientific adventures. Let’s continue to strengthen our community and advance the fields of metabolomics and fluxomics together! 🚀

🚨 The RFMF Board of Directors met in Nantes on January 9th and 10th! 🚨

We worked for the community:

- > reviewing past actions ✅
-> planning new initiatives for 2025 🚀.

Stay tuned to follow our upcoming projects! ✨

#RFMF #Metabolomics #Fluxomics #Nantes

Very happy to introduce MS2DECIDE, a decision theory-based cheminformatics tools for NP prioritization from multiannotated MS/MS data. Have a look at our preprint
@ChemRxiv rb.gy/1qn6c6
@LAMSADEDauphine @Paris_Dauphine @BioCIS @UnivParisSaclay @cnrs.bsky.social