Alberto Perez-Posada

Un viaggio all’origine dei sistemi nervosi Il nuovo progetto GRNevo, finanziato con un grant FIS-3 Advanced da 1,9 milioni di euro, studierà come si formano i neuroni durante lo sviluppo in specie animali molto distanti tra loro: dal moscerino...

Thrilled to share that I’ve been awarded a FIS-3 Advanced Grant (ERC-inspired) to study the evolution of neurogenic GRNs.
Recruiting soon: 4 postdocs + 3 PhDs
Press release in Italian — to decolonise scientific language 😄
magazine.unibo.it/it/articoli/...
Email me if interested in joining the lab

🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist!
#Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟
📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain)
🕒 Full-time, 3-year position (start March 2026)
📅 Apply by Feb 15, 2026
👉 drive.google.com/file/d/1M8rp...

Decoding cnidarian cell type gene regulation - Nature Ecology & Evolution This study reconstructs the gene regulatory networks that define cell types in the sea anemone Nematostella vectensis, providing a valuable resource for comparative regulatory genomics and the evoluti...

Excited to share the final version of our study on Nematostella cell type regulatory programs. Part of our @erc.europa.eu StG project, this was a challenging 5-year effort extraodinarily led by @aelek.bsky.social and @martaig.bsky.social.

www.nature.com/articles/s41...

Decoding cnidarian cell type gene regulation - Nature Ecology & Evolution This study reconstructs the gene regulatory networks that define cell types in the sea anemone Nematostella vectensis, providing a valuable resource for comparative regulatory genomics and the evoluti...

Lovely Xmas gift 🎄—our paper is out today in @natecoevo.nature.com www.nature.com/articles/s41...! Huge thanks to everyone who made it possible, especially @aelek.bsky.social and @arnausebe.bsky.social

Exciting news to start the new year! We’re thrilled to see this work finally out in @natecoevo.nature.com, the result of a major collaboration between my lab and the labs of Veronica Hinman and Nacho Maeso, began many years ago with the dear José Luis Gómez-Skarmeta.
www.nature.com/articles/s41...

(Cont. ; I'm very used to long posts from Mastodon): Thanks to @gacthel.bsky.social, Elena Emili, Anna Guixeras, Virginia Vanni, @drsalamander.bsky.social, @cireniasketches.bsky.social, Siebren Frölich, Simon Van Heeringen, Francesc Cebrià, @spiralcleavage.bsky.social & @jordisolana.bsky.social

We hope this work proves a valuable resource for the community (lots of classic functional experiments re-mapped to recent versions of the planarian genome), and helps paving the way into new hypotheses about which genes and regulatory elements mediate stem cell differentiation.

Once again thanks!

I learned so, so much in this project. Not only in terms of tools and analyses, but especially from the rest of the team, friends & peers at @jordisolana.bsky.social . Including critical thinking, how to coordinate a whole project -it's massive-, and how to communicate this research.

Very happy to announce that our article in multimodal single cell analyses in planaria is out in Nature Communications @natcomms.nature.com ! Thank you very much to everyone that made this work possible. I am very happy to see it out (: www.nature.com/articles/s41...

Just uploaded our new preprint to @ecoevorxiv.bsky.social

Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀

We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...

Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social

Just gonna put this here for now
www.science.org/doi/10.1126/...
bsky.app/profile/jlst...

Picture of #LifelongDevSI Guest Editor Mansi Srivastava taken in an office with a whiteboard and sunny window. Mansi is wearing a white shirt and a flower pendant necklace with colourful petals

Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.

journals.biologists.com/dev/article/...

congratulations @xgrau.bsky.social @arnausebe.bsky.social and the rest of the authors!

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation | Molecular Systems Biology imageimageA multiomics study of zebrafish spermatogenesis integrating scRNA-seq, scATAC-seq, and base-resolution DNA methylomes defines the chromatin and transcriptional states of germ cells, revealing the regulatory dynamics of this continuous ...

www.embopress.org/doi/full/10....

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Really grateful to see our work featured by @quantamagazine.bsky.social in this piece on the evolution of genome regulation. Huge thanks to @philipcball.bsky.social for such a beautifully written article.

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

Congratulations, amazing work! I remember when you explained to me the TF/motif strategy in the Sevilla meeting. I'm happy it worked well!

I am very happy to have posted my first bioRxiv preprint. A long time in the making - and still adding a few final touches to it - but we're excited to finally have it out there in the wild:
www.biorxiv.org/content/10.1...
Read below for a few highlights...

A single-cell ATACseq atlas of our favourite sea anemone, Nematostella vectensis! By @aelek.bsky.social @martaig.bsky.social

Congratulations to the new PhD at #CABD: Marta Moreno Oñate!

Dr. Moreno did an amazing job explaining the projects of her PhD work! Marta's thesis was done with @pablodeolavide.upo.es’s PhD program and was co-supervised by @martinfranke.bsky.social and Juan Tena!

I am very proud of you, Marta. You did outstanding work in the lab, and your defence was spotless. I am also very happy to now know an expert in gene compensation between paralogous genes!

Decoding cnidarian cell type gene regulation https://www.biorxiv.org/content/10.1101/2025.07.01.662323v1

And, if it turns out these long computation times are not due to lack of parallelisation, then there is something very strange going on that should be investigated. Functions like FindVariableFeatures, ScaleData, and others, are now reported to take several hours for 10K~30K cells datasets.

What is the current status of parallelisation support in Seurat? It was dropped last year with v5 and so far nothing has changed. It is not good that multiple people are reporting very slow runtimes (myself included).
github.com/satijalab/se...
github.com/satijalab/se...
github.com/satijalab/se...

Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances!

www.science.org/doi/10.1126/...

Are animals of different sizes made of the same cell types?

Here’s an update of the main points and revision items

(with memes!)

Thread 👇🧵

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Lungfish xkcd.com/3064

Y'all so excited to build this world lol