Chloe M. Hall

Super cool!

Interesting! I wonder how accessible it even is really at the moment though, aren’t there still very low numbers of PD patients treated with DBS vs other therapies?

A multicolored confocal microscopy image with blood-brain barrier cells in a microfluidic device on a black background. Red colored endothelial cells are in the left channel, green astrocytes, and purple pericytes are in the right channel. The channels are connected by small openings

Confocal microscopy image of endothelial cells highlighting their tight junction proteins in yellow (ZO-1) and red (Claudin 5) on a black background

A new #FluorescenceFriday for today! ✨🔬🧠

My 1st time assembling a full #BloodBrainBarrier in a #microfluidic device.

🔴 Claudin 5 (endothelial protein)
🟡 ZO-1 (endothelial protein)
🟢 GFAP (astrocytes)
🔵 DAPI (cell nuclei)
🟣 NG2 (pericytes)

#neuroskyence #neuroscience #bbb #microscopy #confocal

The Global CEO Initiative on Alzheimer’s Disease Launches Groundbreaking Alzheimer’s Blood Test Performance Database for Clinicians A First-of-Its-Kind Resource Empowering Clinicians with Clear, Comparative Insights on Alzheimer’s Blood Test Performance...

Interesting, initiative for looking at performance of blood tests for Alzheimer’s biomarkers : www.globenewswire.com/news-release...

Sourcing in the sulci of deeptech: neuroscience therapeutics 🚨 I’m a neuroscientist- I could wax lyrical about the details of these diseases for YEARS. In fact, I have. But in order to focus on the…

Wondering how neuroscience therapies are being developed? And who is funding them? I wrote an article about this: medium.com/included-vc/...
🟦🧠
#neuroskyence
Feel free to reach out to discuss!

SCIENTISTS DO NOT COMPLY.

THE GOV DOES NOT CONTROL INDEPENDENT PUBLISHING.

Keep on publishing data!!!! Fight back!!!

Sleep microstructure organizes memory replay - Nature The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Encoding of recent memories happens in a distinct phase of sleep compared to replay of older ones.

Nitty gritty: disruption of sleep of 1 substate (small-pupil dilation) of NREM sleep (🐭) reduced remembering of recently acquired but not older existing knowledge

www.nature.com/articles/s41...

Why don’t new memories overwrite old ones? Sleep science holds clues Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.

Why don’t new memories overwrite old ones? It appears that this is because the brain processes new and old memories in separate phases of sleep, which might prevent mixing between the two.

Full details in this nature paper www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...

Important study result;

Vaccines alone don’t protect you from COVID’s brain damage. They help, but not enough.

Only thing you can do to prevent brain damage completely is avoid infection in the first place.

Mask up in crowded and poorly ventilated spaces. (Yes there is a COVID resurgence)

DNArchives: banking on molecular memory Taking inspiration from biology to externalise memory.

Have you ever heard of DNA for storing data? I wrote my first ever deepdive on it, as part of Included VC: check it out here and let me know what you think!
medium.com/included-vc/...

Amazing work from Science Corp: biohybrid implant brain-chip interface- they've grown (🐭) neurons on a microwell which remain viable over weeks, exhibit spontaneous activity and integrate with the mouse brain🤯 🧠🟦
www.biorxiv.org/content/10.1...

"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8

For PFA fixed brains I could get down to 30um slices using the vibratome without embedding- helps if you keep it nice and cold also :)

Excited to be presenting my work using the HD-MEA and human cortical organoids Thursday morning, Poster 293 at #FENS2024. Please stop by, especially if you’re interested in ephys in organoids 🧠

Interesting way to compare differences between studies
onlinelibrary.wiley.com/doi/10.1002/...
#statssky

Large language models surpass human experts in predicting... Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer a solution....

"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. arxiv.org/abs/2403.03230 1/6

Is backpropagation truly the most efficient way for neural networks to learn? Would more biologically plausible algorithms be more efficient? #AI #ArtificialIntelligence #NeuralNetworks #neuroscience 🧪

Team #neuroskyence- how many cells can I expect to get per pup in a p1 mouse hippocampus culture? 🧠🧐

GitHub - cxli233/FriendsDontLetFriends at v3 Friends don't let friends make certain types of data visualization - What are they and why are they bad. - GitHub - cxli233/FriendsDontLetFriends at v3

github.com/cxli233/Frie... Such a lovely data vis blog / guide !

It’s beautiful to see how medical students are the same in the UK and Germany… forever complaining about the Krebs cycle 😂

I made a #BioImageAnalysis #GPT 🎉

Compared to #chatGPT it provides more concise hints for processing fluorescence microscopy images using Python libraries my collaborators and yours truly maintain. Thanks to all contributors and as usual: Feedback is 💚ly welcome! 🤗

chat.openai.com/g/g-psAohb1O...

Guide to Effect Sizes and Confidence Intervals

Big 2024 announcement! The “Guide to Effect Sizes and Confidence Intervals” had a pretty substantial update and is slowly becoming the most comprehensive resource on effect sizes and confidence intervals. Here is a thread of some of the new additions 1/5 t.co/ByeSMQNJdp

Duolingo-Vogel Duo winkt in die Kamera und sagt "Lass und einen Blick auf deine Fehler werfen!"

Mein Hirn, wenn ich abends im Bett liege und schlafen will.

Hi Megan- not quite sure why that would be… we do recommend going fullscreen in a browser, so perhaps it works better in another browser?

Powered by Gorilla Make the world a better place by participating in cutting edge behavioural research. Powered by Gorilla

Hi neuroscientists- are you able to outperform an LLM? We have 2 versions of a real neuro abstract, and we need you to find the real one for BrainGPT! Should take around 15-20 mins of your time… #Neuroskyence
research.sc/participant/...

Is anyone working on brain organoids? It'd be nice to find a community #Neuroskyence

Awesome, thanks so much Ana! Looks like a great series, see you Thursday!

Hi Ana! Are these online seminars? Are they open to join?

There are 11 questions, which should take 15-20 minutes. At the end, you get to see how you did, and will have the option of being publicly acknowledged and entering a raffle for a BrainGPT t-shirt. Be a part of the future of neuroscience and help out! research.sc/participant/... 2/2

Powered by Gorilla Make the world a better place by participating in cutting edge behavioural research. Powered by Gorilla

How predictable is neuroscience? Can LLMs outperform humans? Please participate in the BrainGPT.org survey to help us find out. You choose between two versions of a neuro abstract: the original vs. one with altered results. Which is which? research.sc/participant/... 1/2