Dan Jagger

Clinical Features of Children at Risk of Profound Autism - Journal of Autism and Developmental Disorders Purpose The concept of profound autism was coined in 2021 to better describe and understand the needs of autistic people with low cognitive and adaptive functioning skills and limited verbal communica...

Recent study by authors of the article in The Conversation:

"Clinical Features of Children at Risk of Profound Autism"

🧪 @medsky.social
link.springer.com/article/10.1...

A new diagnosis of ‘profound autism’ is on the cards. Here’s what could change Every autistic child has individual strengths and needs. New research investigates how a category of ‘profound autism’ could impact their diagnosis and supports.

A new diagnosis of ‘profound autism’ is on the cards. Here’s what could change.

"When it comes to autism, few questions spark as much debate as how best to support autistic people with the greatest needs."

🧪🧠 @medsky.social
theconversation.com/a-new-diagno...

Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review Bioactive compounds derived from secondary metabolism in animals have refined selectivity and potency for certain biological targets. The superfamily Dendrobatoidea is adapted to the dietary seques...

Open access review on toxic compounds derived from the frog superfamily Dendrobatoidea 🧪🐸:

Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review.

#ionchannels @medsky.social #medsky
www.tandfonline.com/doi/full/10....

What is the dart frog toxin allegedly used to kill Alexei Navalny? The toxin, epibatidine, can be found in frogs in the wild in South America or manufactured in a lab.

What is the dart frog toxin allegedly used to kill Alexei Navalny?

Epibatidine overstimulates nicotinic receptors, causing paralysis, respiratory failure & death.

Dart frogs in captivity don't produce Epibatidine, & it isn't found naturally in Russia.

🧪🐸 #ionchannels
www.bbc.co.uk/news/article...

Breast cancer cell images feature in Greenwich exhibition A scientist whose wife has incurable cancer transforms images of breast cancer cells into artworks.

A scientist whose wife has incurable cancer has transformed microscope images of breast cancer cells into large-scale artworks for an exhibition to educate others and show there is "beauty in everything".

🧪 #sciart
www.bbc.co.uk/news/article...

The new treatment giving people their voices back David Metherell is among a select few patients to receive pioneering treatment to their vocal cords.

The new treatment giving people their voices back.

It involves taking the plasma from the patient's blood and then injecting it into their vocal cords, or folds.

It has been used for tendon or ligament injuries before - but not in this way.

🧪👄 @medsky.social #medsky
www.bbc.co.uk/news/article...

US has ‘squandered’ its claim to world leadership, German chancellor Merz suggests Friedrich Merz was speaking on the first day of the Munich Security Conference, being held in the shadow of Donald Trump’s global influence

US has ‘squandered’ its claim to world leadership under Trump, German chancellor Merz suggests

Oh yes.

Jesus Christ doesn’t care that the Dow crossed 50,000 when people can’t afford food.

I think you've nailed it.

Trump revokes landmark ruling that greenhouse gases endanger public The EPA overturns a key climate regulation that underpins US efforts to tackle climate change.

US President Donald Trump has reversed a key Obama-era scientific ruling that underpins all federal actions on curbing planet-warming gases.

The 2009 "endangerment finding" concluded that a range of greenhouse gases were a threat to public health.

🧪 😒
www.bbc.co.uk/news/article...

We all left a long time ago.

US applications for prestigious European research grants surge Rush for funds to relocate laboratories to Europe is latest sign of a US brain drain.

US applications for prestigious European research grants surge.

The surge in demand could be another sign that a brain drain might be under way in the US, where thousands of research grants have been cut since President Donald Trump returned to the White House.

🧪🔬🔭
www.nature.com/articles/d41...

Dozens of researchers will move to France from US following high-profile bid to lure talent Large proportion worked at Columbia University, which had its grants cut and frozen by the administration of US President Donald Trump.

Dozens of researchers will move to France from the United States following a high-profile bid to lure talent.

A large proportion worked at Columbia University, which had its grants cut & frozen by the administration of US President Donald Trump.

🧪🔬🔭
www.nature.com/articles/d41...

Associations of Lifetime Cognitive Enrichment With Incident Alzheimer Disease Dementia, Cognitive Aging, and Cognitive Resilience | Neurology Background and ObjectivesThe effects of lifetime cognitive enrichment on later-life cognitive outcomes are not comprehensively investigated. The aim of this study was to test the association of lifeti...

Link to new study in Neurology, the journal of the American Academy of Neurology:

Associations of Lifetime Cognitive Enrichment With Incident Alzheimer Disease Dementia, Cognitive Aging, & Cognitive Resilience.

🧪🧠 @medsky.social #medsky #neuroskyence
www.neurology.org/doi/10.1212/...

Reading and writing can lower dementia risk by almost 40%, study finds Cognitive health in later life is ‘strongly influenced’ by lifelong exposure to intellectually stimulating environments, say researchers

Reading & writing can lower dementia risk by almost 40%, study finds.

Engaging in intellectually stimulating activities throughout life was associated with a lower risk of Alzheimer’s disease & slower cognitive decline.

🧪🧠 @medsky.social #medsky #neuroskyence

www.theguardian.com/society/2026...

And yet it survives (just about).

University College London at 200: A potted history The UK's third university, which was founded on 11 February 1826, was the first to admit women.

University College London at 200: A potted history.

"Having become the first university open to applicants regardless of race, class or religious background, in 1878 UCL became the first university in the UK to admit women in all faculties except medicine." 🎓🏛️📜
www.bbc.co.uk/news/article...

Inside Your Brain: 10 discoveries that reveal how the brain works 10 discoveries that reveal how the brain works

"Inside Your Brain: 10 discoveries that reveal how the brain works" by @lucyannunwin.bsky.social & @caswell.bsky.social 🧠🧪
uk.bookshop.org/p/books/insi...

Working on a story for Science about cuts to Canada's government researchers and labs. If you are affected by this please reach out (either on here or via my website). Anonymity is an option. 🧪

It says neighbouring SE Asian countries are watching with interest 👀.

The 4-year project would lay the foundations for such countries to roll out a similar approach.

Funding a clinical trial in Nepal The Trustees of the Howard Foundation are delighted to announce that they are funding a four year research project based in Nepal. The CoDIAPREM (Community-based Diabetes Prevention and&n…

Details of a new 4-year CoDIAPREM (Community-based Diabetes Prevention & Remission) project funded by the Howard Foundation 🧪:

Funding a clinical trial in Nepal.
www.howard-foundation.com/funding-a-cl...

@medsky.social

A service evaluation of weight management for glycaemic control and remission of type 2 diabetes using traditional food in Nepal (Ho-DIRECT NEPAL): a single-arm trial Traditional food-based weight management can valuably improve control, reduce medication needs, and generate remissions of established T2D, but adherence barriers must be overcome to optimise outcomes...

Recent trial of an entirely food-based service in Nepal (open access 🧪):

A service evaluation of weight management for glycaemic control & remission of type 2 diabetes using traditional food in Nepal (Ho-DIRECT NEPAL): a single-arm trial.

@medsky.social #medsky
www.thelancet.com/journals/lan...

Traditional food could help reverse Nepal’s ‘diabetes epidemic’, studies suggest With medication largely unaffordable in the country, experts hope community support and a change in diet could reduce soaring type 2 diabetes rates

Traditional lentil & rice dishes could save Nepal from a diabetes epidemic prompted by the influx of western junk foods.

1 in 5 Nepalis over 40 has type 2 diabetes, which can cause kidney disease, limb loss, blindness & premature death.

🧪 @medsky.social #medsky
www.theguardian.com/global-devel...

Marginal gains, Jon, marginal gains.

Nice work 👍

The authors would probably say you were an outlier ....

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials Adverse event data from blinded randomised trials do not support causal relationships between statin therapy and most of the conditions (including cognitive impairment, depression, sleep disturbance, ...

Open access link to new study in The Lancet 🧪💊:

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials.

#medsky @medsky.social
www.thelancet.com/journals/lan...

Statin pills much safer than advertised, major review finds The results, in The Lancet journal, come from trials involving more than 120,000 people comparing statins with a dummy drug or placebo.

Cholesterol-lowering drugs called statins, are far safer than previously thought, a major review has found.

Leaflets in packs should be changed to reflect this to avoid scaring people off using the life-saving pills, say the authors.

🧪💊 #medsky @medsky.social
www.bbc.co.uk/news/article...