Dan Jagger

Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia | NEJM CD7 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory T-cell acute lymphoblastic leukemia (ALL). Supportive results of first-in-human studies of b...

Link to new trial results in New England Journal of Medicine (full paper accessible with free account):

Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia

🧪🩸🧬 #medsky
www.nejm.org/doi/full/10....

Blood cancer therapy reverses incurable leukaemia in some patients Seven out of 11 patients with incurable cancer who had the treatment appear to be cancer-free.

A genetic therapy has reversed aggressive & incurable blood cancers in ~64% of patients in a trial.

The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".

🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...

So, there's TWO egg holes down there? 😯

Artificial intelligence research has a slop problem, academics say: ‘It’s a mess’ AI research in question as author claims to have written over 100 papers on AI that one expert calls a ‘disaster’

Artificial Intelligence research in question as author claims to have written over 100 papers on #AI in 1 year.

Kevin Zhu’s papers are a “disaster”, said Hany Farid, a professor of computer science at Berkeley, in an interview.

🧪🤖

www.theguardian.com/technology/2...

🧪🔬

Laura can't be arsed.

Japan is facing a dementia crisis – can technology help? Elderly people aged 65 and over now make up nearly 30% of Japan's population.

Last year, >18,000 older people living with dementia left their homes & went missing in Japan. Almost 500 were later found dead.

People are now adopting GPS-based systems to keep track of those who go missing.

Can other forms of technology help in this crisis?
🧪🤖
www.bbc.co.uk/news/article...

Impacts of an industrial deep-sea mining trial on macrofaunal biodiversity - Nature Ecology & Evolution A species-level dataset of sediment-dwelling macrofauna, sampled 2 years before and 2 months after a test of a commercial deep-sea mining machine, reveals losses of macrofaunal density and species ric...

Open access link to the new study in Nature Ecology & Evolution 🧪🦀:

Impacts of an industrial deep-sea mining trial on macrofaunal biodiversity.
www.nature.com/articles/s41...

We're all Paraguay fans now. 🇵🇾

🧪

But it sparkles.

🧪

New Zealand police recovers $19k Fabergé egg swallowed by suspected thief The man allegedly tried to steal the diamond-studded egg named after the James Bond film Octopussy.

A diamond-studded locket swallowed by a New Zealand man who tried to steal it has been "recovered", police say.

The Fabergé egg locket, valued at NZ$33,585 ($19,300; £14,600), was recovered in a "natural" manner.

"Medical intervention [was] not required."

🧪🥚💎🍽️💩

www.bbc.co.uk/news/article...

Impacts of an industrial deep-sea mining trial on macrofaunal biodiversity - Nature Ecology & Evolution A species-level dataset of sediment-dwelling macrofauna, sampled 2 years before and 2 months after a test of a commercial deep-sea mining machine, reveals losses of macrofaunal density and species ric...

Open access link to the new study in Nature Ecology & Evolution 🧪🦀:

Impacts of an industrial deep-sea mining trial on macrofaunal biodiversity.
www.nature.com/articles/s41...

Over a third of animals lost in test deep sea mining - scientists The findings contribute to a controversial debate that pits green technology against the environment.

Deep-sea mining tests impact over a third of seabed animals.

Scientists found that the density of animals found in the tracks of the vehicles was reduced by 37% compared to untouched areas.

The research was conducted at the request of a deep sea mining company.

🧪🦀
www.bbc.co.uk/news/article...

Collateral damage: Cardiovascular and respiratory implications of tear gas deployment during peaceful protest In December 2024, large-scale protests in front of Georgia’s Parliament were met with crowd-control measures involving the widespread use of tear gas …

Open access link to new study in Toxicology Reports, on the effects of "crowd-control measures" involving tear gas & pepper spray:

Collateral damage: Cardiovascular and respiratory implications of tear gas deployment during peaceful protest 🧪
www.sciencedirect.com/science/arti...

WW1 toxic compound sprayed on Georgian protesters, BBC evidence suggests. 🧪
www.bbc.co.uk/news/article...

I strongly suspect my son became a victim of this crime too, meaning using a World War One-era chemical weapon at the #GeorgiaProtests by GD.

He has developed serious lung issues in March out of blue and was diagnosed with chronic bronchiectasis. I have consultations with his doctors on this matter

Ramen under a red light.

I think this is how a snake sees dinner. 🧪🍜🟥

A reminder that London is far safer than many major cities, that crime is falling and that racists hate both these truths because they undermine their vicious little divisive narrative.

Multiculturalism works. London works. And those who hate both things hate themselves most of all.

Will there be pizza?

Feel free to move them to the science fiction section.

Does the brain always rely on all past information when predicting what comes next? My first first-author paper is out! 🎉 A work with @robertabianco.bsky.social @EdwardHall @MarcusPearce and @mariachait.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...

🧪🧠☝️ #neuroskyence

I'm just thinking about chocolate digestives now.

The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism Leopard cats lived commensally with humans in ancient China for over 3,500 years before domestic cats were introduced via Silk Road merchants around 1,400 years ago. Ancient DNA shows that while two s...

New related open access study in Cell Genomics 🧪🐱🐾:

The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.
www.cell.com/cell-genomic...

The dispersal of domestic cats from North Africa to Europe around 2000 years ago The domestic cat (Felis catus) descends from the African wildcat Felis lybica lybica. Its global distribution alongside humans testifies to its successful adaptation to anthropogenic environments. Unc...

New study in Science magazine 🧪🐱🐾:

The dispersal of domestic cats from North Africa to Europe around 2000 years ago.
www.science.org/doi/10.1126/...

Cats became our companions way later than you think In true feline style, cats took their time in deciding when and where to join us on the sofa.

Cats became our companions way later than you think.

The shift from wild hunter to pampered pet happened much more recently than previously thought - and in a different place.

All modern cats are descended from the same species - the African wildcat.

🧪🐱🐾 #catsky
www.bbc.com/news/article...

🎯