Brandon (A+++++) Greene

What is that monstrosity? Is that zucchini in there?

I footballed really well this year.

Quick poll (while I’m at the pharmacy). How much would they have to pay you to be a Depends model?

The delivery of “we locked him up. Going to be passing a background check no time soon” was chefs kiss, no notes.

There is a way to thread the needle here. University presidents and other leaders don't have to just go out and bash the administration. But at the very least, they have to aggressively and coordinately make the case for the VALUE of SCIENCE to individuals, communities, and the country as a whole

It also rationalizes quiet, self-preserving, short-term efforts which will likely come at the cost of long-term damage. Maybe the funding stays flat with inflation or is only marginally cut, but the real damage is being done on the future. Jr. scientists are demoralized we're losing the public 3/

This rationale, framed against the historical movements of the civil rights movement, the withdrawal from Vietnam, etc. seems to miss how essential it was to not just have everyday people demonstrate, but vociferous condemnation of bad policy/ideas from cultural and institutional "elites." 2/

A tale of many twos For the American scientific enterprise, the past year has seemed awash in contradiction. On the one hand, it has produced great upheavals and losses for US science. Many universities experienced some ...

Finally worked up the patience to read a much-discussed @holdenthorp.bsky.social 's editorial in @science.org. The thesis seems to be 'don't be mad that most scientific leaders kept quiet and tried to work calmly work with Rs because we didn't see draconian cuts.' 1/
www.science.org/doi/10.1126/...

I don’t know, is that true? Or did they know exactly what he was and aspired to it?

Jesus.

It’s both a flex that you can do it and that he does. I hope I’m as generous at his age and that anyone cares 😂

That’s a flex.

Time to clean…

Watched October Sky last night and 1. I think this had a significant influence on me as a kid becoming a scientist and 2. We can capture this energy again as a country. A politician who can tap into this will do well.

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

A totally predictable/avoidable outcome.
www.science.org/content/arti...

We need to get of our scientific preconceived notions!

Here are my scientific preconceived notions!

open.spotify.com/episode/7vfd...

Take back our science rally! March 7th 2026. standupforscience.net/march7

GET IN, DORKS!
The stakes are high and we have a LOT to stand up for in 2026.

Join us on March 7th, 2026! www.standupforscience.net/march7

Want to host an event in your area? Sign up here: fight2win.standupforscience.net/sign_up/14434/

#Standupforscience #takebackourscience

Measurement and Control of Crossed Potentials in a Flavoprotein Flavoproteins constitute 1–3% of prokaryotic and eukaryotic proteins, functioning as electron transfer agents, catalysts, and sensing or regulatory modules. Their versatility as redox-active proteins stems from the tunability of the flavin cofactor’s one- and two-electron reduction potentials via interactions with the protein scaffold. Although several mechanisms have been proposed to explain how the flavin-binding pocket modulates redox thermodynamics, a holistic model enabling interpretation and prediction remains to be established. In this study, we investigate how the flavin N5 environment influences the redox properties of the flavin mononucleotide cofactor in the “improved” light-oxygen-voltage (iLOV) sensing protein using site-directed mutagenesis, redox titrations, and hybrid quantum mechanical molecular mechanical (QM/MM) methods combined with classical alchemical free energy simulations. Mutating the residue Q103, which interacts with the flavin N5 and O4 atoms in the X-ray crystallographic structure, exerts a modest <35 mV effect on the overall two-electron reduction potential, but significantly alters the potential separation of the two one-electron couples (potential crossing) by up to 168 mV. QM/MM and free energy calculations reveal that water penetration into the flavin-binding pocket near N5 and O4 largely explains the trend in reduction potentials among the mutants. The results suggest a molecular mechanism of flavin tuning in which hydrogen bonding to the neutral semiquinone, either directly by the side-chain or a protein-penetrating water, contributes significantly to the potential crossing. These findings establish quantitative experimental benchmarks for theoretical models and advance a molecular mechanism for redox tuning in flavoproteins.

It's finally out! Great work Ben, Sichu, Sarah, Brett, Ian and Samer for the wonderful science and effort here. The role of the N5 environment in tuning flavin reduction potentials.
pubs.acs.org/doi/10.1021/...

Ross isn’t a great critical interviewer, but this was just one straw man argument after another, no critical thought on what was actual “definitive” public health advice vs. recs and the damage to public health trust to just throw up your hands and let it rip.

It’s disturbing to think of what that decision tree looked like. It has changed. As a leader, if an officer is involved in a significant altercation, it seems more that prudent to give them the time and space to normalize. Unless your intention is not normal…

That tech oligarchs are noisy and incensed about the remote possibility of a wealth tax and utterly silent about the murder of a man who was only using the phone they invented to chronicle the thuggish government goon squads should tell you everything about these desiccated souls.

YouTube video by Takes™ by Jamelle Bouie ICE Kills Another American

youtu.be/H_71MhRqpVM

Absurd is right.

US science after a year of Trump: what has been lost and what remains A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.

Thanks @nature.com for the beautifully depressing article!
www.nature.com/immersive/d4...

“The border between democracy and fascism is the least defended border in the world” Ivan Krastev

Opinion | How Trump Has Used the Presidency to Make at Least $1.4 Billion The president took an oath to serve the American people. Instead, he’s focused his second term on enriching himself and his family.

Visuals dept. at NYT is crushing it recently.

www.nytimes.com/interactive/...

His interest in the food I make is inversely proportional to how much time it takes to make

Breakfast made for kiddo: blueberry sourdough French toast, a poached egg, and chicken sausage.
Kiddo ate: pineapple

Great way to start my day! But seriously, thanks for sharing

For extra literary impact, highlight-copy-paste yields the unredacted text