Tobias Greisle

Thanks, I hope it's helpful!

Happy to share a new tool from the @heikolickert.bsky.social lab!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!

Benchmarking porcine pancreatic ductal organoids for drug screening applications Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

Liver and pancreas in metabolic disease: from pathways to therapies The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

My top highlight for 2025 - EMBO workshop in Saint Feliu - three exciting days of science crossing boundaries of liver & pancreas research! Co-organised by @CebolaLab @1jorgeferrer @VallierLab @LickertHeiko & Emma Anderson #livertwitter #islets #masld #diabetes

meetings.embo.org/event/25-liv...

Liver and pancreas in metabolic disease: from pathways to therapies The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD

meetings.embo.org/event/25-liver-pancreas

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social