Trick or Treat! π»π
10.11.2025 19:23 β π 0 π 0 π¬ 0 π 0
21.10.2025 03:46 β π 6 π 1 π¬ 0 π 0
(4/4) Our findings redefine the role of TGF-Ξ² signaling in early development and suggest conserved parallels between embryonic diapause, stem cell quiescence, and cancer dormancy.
09.10.2025 20:08 β π 1 π 0 π¬ 0 π 0
(3/4) Mechanistically, Smad2 represses the metabolic regulator Pparg, preventing lipid accumulation that is incompatible with dormancy. This links signaling, metabolism, and chromatin control during developmental pausing.
09.10.2025 20:08 β π 0 π 0 π¬ 1 π 0
(1/4) New Pre-print! π
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.
09.10.2025 20:08 β π 10 π 4 π¬ 1 π 0
2026 Election Nominations β International Society for Stem Cell Research
Elections and nominations for the International Society for Stem Cell Research board of directors and officers.
The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more π https://www.isscr.org/nominations
08.10.2025 16:01 β π 0 π 2 π¬ 0 π 0
John Gurdon was a true giant:
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.
07.10.2025 19:57 β π 49 π 11 π¬ 1 π 0
π¨ JOB ALERT π¨
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at
@sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
24.09.2025 16:05 β π 2 π 2 π¬ 0 π 0
Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.
09.09.2025 17:06 β π 10 π 2 π¬ 2 π 0
(4/4) These findings provide new insights on the chromatin-level regulation of MYC-driven breast cancer and uncover CHD1 as a novel synthetic lethal vulnerability and potential therapeutic target.
04.09.2025 19:11 β π 0 π 0 π¬ 0 π 0
(3/4) We found that CHD1 is required to maintain an open chromatin landscape and a transcriptional program associated with cancer progression in MYC overexpressing breast cells and that this synthetic lethality may arise from nucleolar stress and p53 activation.
04.09.2025 19:11 β π 0 π 0 π¬ 1 π 0
(2/4) We found that knockdown of CHD1 in a xenograft model of MYC-driven breast cancer suppresses tumor growth in vivo. In tissue culture models, knockdown of CHD1 suppresses cell proliferation and induces cell death, specifically when MYC is overexpressed.
04.09.2025 19:11 β π 0 π 0 π¬ 1 π 0
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer
The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...
(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...
04.09.2025 19:11 β π 7 π 1 π¬ 1 π 0
π Let's enjoy the summer time in Toronto! ποΈ
25.07.2025 15:17 β π 1 π 0 π¬ 0 π 0
(3/3) We show that alpha satellite RNA is required for maintenance of the perinuclear compartment and for maintaining a low transcriptional output, including of ribosomal RNA, in human embryonic stem cells.
21.07.2025 20:12 β π 0 π 0 π¬ 0 π 0
(2/3) We found that alpha satellite RNA is highly chromatin-bound and localizes to the perinuclear compartment, a domain of the nucleus previously only thought to exist in cancer cells.
21.07.2025 20:12 β π 0 π 0 π¬ 1 π 0
β³Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference!
π§ͺShare your exciting discoveries with us!!
πMalta
ποΈTalk Deadline: July 10
πhttp://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
04.07.2025 08:21 β π 4 π 5 π¬ 0 π 1
Professor, Epigenetic inheritance of disease
University of Montreal Hospital Research Centre (CRCHUM), Department of Pathology, Molecular and Cellular Biology
McGill University, Department of Pharmacology and Therapeutics
Associate Prof at Baylor College of Medicine. Brain tumor research at Texas Children's Hospital. Houston, TX. π¨π¦ in πΊπΈ
https://www.bcm.edu/research/faculty-labs/marco-gallo-lab
Asst Prof McMaster OBGYN #omics | #epigenomics | #bioinformatics | #genomics | #placenta | #preeclampsia | #machinelearning | #cfDNA | #FirstGen She/her π¨π¦π¦πΊ
Come for the science, stay for the corgi pics
Reproductive biologist π΅πΉ in π©πͺ
Institute of Reproductive Genetics, CMG, Uni-MΓΌnster
PI CRU326 "Male Germ Cells"
DNA methylation, spermatogenesis, ageing, male infertility
Hobby collector, slowest runner in the west
https://linktr.ee/SandraLaurentino
"Regulation of cytoskeleton dynamics" lab, at Institut Jacques Monod.
https://www.actindynamics.net/
Small RNA biologist at UPenn & CHOP
www.coninelab.com
Interested in small RNAs, germlines, inheritance, sports, and Shiba Inuβs
Laboratory for Immunochemical Circuits at the La Jolla Institute for Immunology. Dept. of Pharmacology and Moore's Cancer Center, UCSD. Global Autoimmune Institute Assistant Professor. samyerslab.org
Group Leader @Centre de Recherche du CHU de QuΓ©bec-UniversitΓ© Laval #NewPI
RNA-binding proteins and microRNAs in development and beyond.
Postdoctoral fellow at the Crick Institute&UCL transitioning to independence. Interested in tissue, stem cells and genome biology. Fascinated by endocrine system.
Father, husband, scientist. Cell Biology Professor. IMIBIC - UCO
Editor in Chief Endocrine Oncology @endocrineoncology.bsky.social
Biomedical research: hormones & cancer, RNA splicing
Pancreatic Cancer, Neuroendocrine tumors NETs π¦
Always with a smile π
Interested in how cells use genes to create shape, form and function in #embryos as well as in Societal Wellbeing
#NotInTheGenes #InNumbersWeTrust #gastruloids #gastrulation
We are a lab studying the molecular mechanisms of epigenetics and how epigenetics impacts a variety of biological processes and diseases.
https://thegreerlab.com/
Assistant Professor @Cornell University
- Germline gene regulation, gene silencing, chromatin
- jongminkimlab.org
Associate Professor | Mom | first-gen | she/her | genetics | chromatin | zebrafish | dev biology | epigenetics | MZT/ZGA | grad training
Associate Professor | UNC Chapel Hill, Pharmacology Department | Lineberger Comprehensive Cancer Center | Research in Endocrinology, Epigenetics, & Wnt signaling| Views my own. https://www.med.unc.edu/pharm/pruittlab/team/
Professor at Oregon Health & Science University, stem cell biologist, neural regen-ologist, and award eligible!
www.bretpearsonlab.org
Organizational principles of cancer | www.greenwald-lab.org at Lunenfeld-Tanenbaum Research Institute & Assistant Professor, Dept. of Molecular Genetics, University of Toronto | Mother of 4, lover of candy, art, & books
Molecular Biologist (aemonten.github.io) δΈ¨Chief Editor @ CSH Protocols (cshprotocols.cshlp.org) δΈ¨Head of the Integrity in Publishing Group at CSHL Press δΈ¨Chair "Molecular Biosystems Conference" (molbiosystems.com) δΈ¨(Oxford) Comma King δΈ¨Central Dogma Police
Assistant Professor at UT MD Anderson Cancer Center.
Our lab studies transposable elements and viral mimicry in (ovarian) #cancer initiation. #newPI
Lab site: https://www.mdanderson.org/research/departments-labs-institutes/labs/ishak-laboratory.html
Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824
