It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon
20.06.2025 08:52 β π 5 π 3 π¬ 0 π 0
We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...
19.06.2025 11:07 β π 22 π 6 π¬ 1 π 8
Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science
19.06.2025 11:23 β π 8 π 2 π¬ 2 π 0
Lovely work!
15.05.2025 17:49 β π 2 π 0 π¬ 0 π 0
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
β’PD-1 & Lag3 exhibit layered control of CD4 T cell activation
β’Co-blockade enhances NFAT-dependent TCR transcription
β’NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
12.05.2025 08:03 β π 19 π 6 π¬ 2 π 0
Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.
12.05.2025 13:29 β π 1 π 1 π¬ 1 π 0
Thank you! Yes, we have only largely looked at a few markers in the functional assays. I think as our model is very TCR signal driven (tolerogenic) it suggests it may more preferentially signal down that pathway. In terms of under co-stimulation or CD8 biology, we have not yet looked!
12.05.2025 13:35 β π 1 π 0 π¬ 0 π 0
#immunosky π§ͺ
12.05.2025 08:08 β π 0 π 0 π¬ 0 π 0
We are now seeking to understand relevance of these pathways are relevant in the immune related adverse events (irAEs) space and tumour environment!
12.05.2025 08:03 β π 2 π 0 π¬ 1 π 0
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
β’PD-1 & Lag3 exhibit layered control of CD4 T cell activation
β’Co-blockade enhances NFAT-dependent TCR transcription
β’NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
12.05.2025 08:03 β π 19 π 6 π¬ 2 π 0
π₯ Open postdoc position in human inflammation-driven control of infection! π₯
Join me at the University of Geneva, Switzerland this summer as Iβm moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
13.04.2025 15:58 β π 50 π 44 π¬ 9 π 0
Shining a light on the Lister Instituteβs connection to the University of Birmingham β Lister Institute
Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...
14.04.2025 14:33 β π 3 π 2 π¬ 0 π 0
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, RΓΌttger et al.
11.04.2025 16:17 β π 39 π 11 π¬ 0 π 1
Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! π§ͺ #immunosky
11.04.2025 08:54 β π 8 π 3 π¬ 0 π 0
#immunosky π§ͺ
11.04.2025 07:23 β π 0 π 0 π¬ 0 π 0
Figure 4 from paper shows how anti-IFNg reduces markers of TCR signal strength and attenuates Tr1 cell differentiation in the Tg4 model
Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNΞ³
- Anti-IFNΞ³ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNΞ³ additively reduces Tr1 cell frequency
11.04.2025 07:21 β π 1 π 0 π¬ 1 π 0
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
11.04.2025 07:21 β π 38 π 7 π¬ 2 π 1
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
@jem.org
rupress.org/jem/article-...
08.04.2025 00:11 β π 8 π 1 π¬ 0 π 0
What better way to get into that Friday feeling than reading our new paper? First author @hlpeks.bsky.social and I will be doing a tutorial on @arrdept-ucldom.bsky.social next Tuesday lunchtime for those who are interested in reading the highlights π
28.03.2025 13:19 β π 10 π 4 π¬ 0 π 0
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
28.03.2025 13:12 β π 23 π 8 π¬ 1 π 3
π£ New Review Alert!
Do you think glial cells are simply neuronal support cells in the CNS?
Did you know glial cells are integral to barrier organs?
Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem
23.01.2025 10:11 β π 25 π 11 π¬ 1 π 0
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
Excited for our lab's FIRST paper #ScienceImmunology! π
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social π
#Tpex #onthescoreboard
www.science.org/doi/full/10....
31.01.2025 19:51 β π 34 π 7 π¬ 2 π 4
The BSI has grants available for our members who want to help get more people excited about #immunology
16.01.2025 16:40 β π 3 π 1 π¬ 0 π 0
PhD Opportunities β MRC AIM
β° Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester π§΅
07.01.2025 11:49 β π 1 π 1 π¬ 1 π 1
great opportunities!
13.12.2024 18:53 β π 0 π 0 π¬ 0 π 0
Iβm so excited about this project, itβs going to reveal so much about how the glycocalyx works, amazing opportunity!!
13.12.2024 18:41 β π 9 π 4 π¬ 1 π 0
Blueksy Mentions are now in Altmetric.
It's been 84 years meme
#AcademicSky #HigherEd #MedSky #HMSky #Altmetrics #Medlibs #Metascience
BLUESKY MEGA-THREAD
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
03.12.2024 14:00 β π 2354 π 666 π¬ 39 π 145
βA place of joyβ: why scientists are joining the rush to Bluesky
Researchers say the social-media platform β an alternative to X β offers more control over the content they see and the people they engage with.: https://www.nature.com/articles/d41586-024-03784-6
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
03.12.2024 14:00 β π 2534 π 676 π¬ 49 π 103
Scientists, academics, researchers: Weβre excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! π§ͺ
03.12.2024 14:10 β π 29990 π 5097 π¬ 466 π 281
Researchers at the University of Birmingham, Centre for Liver and Gastrointestinal Research, UK
Immunology postdoc in @bainlab.bsky.socialβ¬
School of Infection & Immunity at The University of Glasgow
MRC Career Development Fellow at Newcastle University. Studying how pathogens control their genes
Scientist | Immunologist studying regulation at Mucosal Barriers #IBD - interested in immune-stromal crosstalk, vascular biology and regenerative Medicine | Group Leader @MaynoothUniversity.ie
Transforming routine immune profiling to power the future of medicine. I3H builds on Penn Medicineβs pioneering legacy in immunology to advance discovery across disciplines. Perelman School of Medicine, University of Pennsylvania
π www.med.upenn.edu/i3h
Assistant Professor at McGill University/ Goodman Cancer Institute studying myeloid cells in breast and ovarian cancers. π¬π§ in π¨π¦
Postdoctoral researcher @ La Jolla Institute for Immunology ~ Computational Immunology ~ AIRR Community ~ immuneML developer (https://immuneml.uio.no/) ~ AKC developer (https://airr-knowledge.org/)
Based in the Department of Oncology at the MRC WIMM, University of Oxford | We study the genetics of immunity with a focus on the determinants of response to cancer immunotherapy.
Genetics, immunology, oncology, science.
Postdoc in @emmersonlab-irr.bsky.social studying the salivary gland macrophage niche.
Dad of two, Professor, Lister Research Fellow and Wellcome Investigator at the John Innes Centre. Interested in bacterial chromosome organization & segregation, plasmids, and phages.
www.tunglelab.org
π New discoveries in cellular & molecular #immunology
New #OpenAccess journal from @britsocimm
Professor of Immunology at Glasgow University.
Editor in Chief of Discovery Immunology, a British Society for Immunology journal.
Scottish Immunologist based in The School of Infection & Immunity at The University of Glasgow.
Honorary Fellow at The Institute for Regeneration and Repair at The University of Edinburgh.
LIG. Regional interest group of the BSI @britsocimm.bsky.social | A network of researchers passionate about immunology
Email: ligbsicommittee@gmail.com
Scientific Editor at Journal of Experimental Medicine @jem.org @rupress.org. Interested in T cell biology, mucosal immunology, and cancer immunology
Senior Research Fellow/Principal Investigatorπ UCL π₯Ό PhD in immunology π¦ Research in Lupus πΊπ¦ https://orcid.org/0000-0001-7473-7652
Dad/husband/family π Spurs βͺοΈ
Author/illustrator of ImmuNinjas π₯·π
https://amazon.co.uk/ImmuNinjas-2-book-series/dp/B0C65S1J5L
machine learning for health at microsoft research, based in cambridge UK π» she/her
Assoc. Prof. Infectious Disease, University of Birmingham. Interests include Meningitis, Global Health, Immunology and Cycling
Ballou Lab at the MRC CMM, University of Exeter. How do fungi make different shapes and cause disease? Obsessed with microscopes.
