Bending Lab UK

yes…

UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

www.bbc.co.uk/news/article...

UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

www.bbc.co.uk/news/article...

MRC funding update An update on MRC funding during UKRI’s transition, what’s changing, and the next steps for paused opportunities and reopening timelines.

How to reconcile the end statement “UKRI’s overall research and innovation budget is rising…”

with earlier

“we unfortunately expect to make a reduced number of awards to applications currently being assessed”

This statement if anything makes things worse
www.ukri.org/blog/mrc-fun...

a man is sitting on a swing in the grass ALT: a man is sitting on a swing in the grass

Has the MRC made a public statement yet

It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science

Lovely work!

PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social

Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.

Thank you! Yes, we have only largely looked at a few markers in the functional assays. I think as our model is very TCR signal driven (tolerogenic) it suggests it may more preferentially signal down that pathway. In terms of under co-stimulation or CD8 biology, we have not yet looked!

#immunosky 🧪

We are now seeking to understand relevance of these pathways are relevant in the immune related adverse events (irAEs) space and tumour environment!

PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

buff.ly/49bKcTG

By Jobin, Seetharama, Rüttger et al.

Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky

#immunosky 🧪

Figure 4 from paper shows how anti-IFNg reduces markers of TCR signal strength and attenuates Tr1 cell differentiation in the Tg4 model

Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency

Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development

www.cell.com/iscience/ful...

Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
@jem.org
rupress.org/jem/article-...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...

What better way to get into that Friday feeling than reading our new paper? First author @hlpeks.bsky.social and I will be doing a tutorial on @arrdept-ucldom.bsky.social next Tuesday lunchtime for those who are interested in reading the highlights 📖

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...

📣 New Review Alert!

Do you think glial cells are simply neuronal support cells in the CNS?

Did you know glial cells are integral to barrier organs?

Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

Excited for our lab's FIRST paper #ScienceImmunology! 🎉

Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social

Huge thanks to reviewers & @claireolingy.bsky.social 🙌

#Tpex #onthescoreboard

www.science.org/doi/full/10....

The BSI has grants available for our members who want to help get more people excited about #immunology

⏰ Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester 🧵