Sumedha Nalluru

Desensitization of opsin responses during all-optical interrogation depends on imaging parameters Significance The combination of two-photon calcium imaging and two-photon optogenetic stimulation, termed all-optical interrogation, provides spatial and temporal precision when recording and manipula...

All-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...

** We have up to TWO funded PhD positions available in our lab!! Apply below to find new ways to enhance memory👇 Pls retweet **

Deadline: 2nd December

1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6

2. TUS and TMR in humans:
tinyurl.com/jjws5ctj

Happy to chat to interested applicants.

Still a bit stunned but delighted to receive this from @royalsociety.org

I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!

www.biorxiv.org/content/10.1...

Energy of novel and familiar stimuli

New unit paper on “Predictive coding model detects novelty on different levels of representation hierarchy”, published in Neural Computation.

www.mrcbndu.ox.ac.uk/papers/predi...

@mrcbndu.ox.ac.uk @ndcnoxford.bsky.social @ox.ac.uk

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social !
With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding.

(1/13)

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex High-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.

Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦

Constructing future behavior in the hippocampal formation through composition and replay - Nature Neuroscience A model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.

Happy to share the latest version of our work on compositional maps in hippocampus with Jo Warren, @jcrwhittington.bsky.social, @behrenstimb.bsky.social. We propose hippocampus constructs maps from cortical building blocks in replay – now with empirical support! www.nature.com/articles/s41... 1/9

New preprint out with @summerfieldlab.bsky.social! When does new learning interfere with existing knowledge? We compare continual learning in humans and artificial neural networks, revealing similar patterns of transfer & catastrophic interference (1/8) osf.io/preprints/ps...

GitHub - marcelbinz/Psych-201 Contribute to marcelbinz/Psych-201 development by creating an account on GitHub.

We are currently building the largest, cross-domain data set of human behavior as part of an open collaborative project. Contributions of any form are welcome, but especially experiments with meta-data from developmental, cross-cultural, or clinical studies.

More details: github.com/marcelbinz/P...

Many thanks to the reviewers for their useful comments and feedback.

We show that memory reactivation during awake rest plays a critical role in extracting new, unobserved associations to support adaptive behavioural strategies such as inference. 6/6

TMR improved discovery of new, non-directly trained associations, and no change was observed for directly trained associations. 5/6

We demonstrate that TMR during awake rest enhances performance on associative memory tests. 4/6

We investigated this using a pre-registered, within-subject human study design with a rich behavioural paradigm. We used contextual Targeted Memory Reactivation (TMR) to causally manipulate memory reactivation during awake rest. 3/6

Periods of rest and sleep are reported to facilitate adaptive behaviours, such as our ability to make inferences, perform abstraction and acquire insight. However, the mechanism by which these adaptive behaviours emerge remains unclear. 2/6

Our paper "Memory reactivation generates new, adaptive behaviours that reach beyond direct experience" is now out www.nature.com/articles/s41...! With Annie Rawson, Jill O’Reilly and Helen Barron at MRC BNDU @ndcnoxford.bsky.social 1/6