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Spagnoli_Lab.

@labspagnoli.bsky.social

Developmental and stem cell biology lab. @KCLstemcells @kingscollegelondon.bsky.social‬ www.spagnolilab.org Unlocking the control of cell identity and plasticity Also on the otherside: @LabSpagnoli on the bird & @SpagnoliLab@mas.to

1,890 Followers  |  365 Following  |  48 Posts  |  Joined: 14.10.2023  |  2.0441

Latest posts by labspagnoli.bsky.social on Bluesky

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Advances in liver and pancreas organoids: how far we have come and where we go next Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2025; doi:10.1038/s41575-025-01116-1Advances in organoid culture have enabled the modelling of many aspects of organs in vitro, transforming experimental biology. This Review provides a comprehensive overview of the current and emerging liver and pancreas organoid technologies and discusses current limitations and future directions.

ICYMI: New online! Advances in liver and pancreas organoids: how far we have come and where we go next

11.10.2025 19:01 — 👍 2    🔁 2    💬 0    📌 0

New publication :
Despite being a core member of the PCP pathway, Vangl2 can play roles unrelated to planar polarity. This is the case during mouse heart morphogenesis.

26.09.2025 19:22 — 👍 14    🔁 7    💬 1    📌 0

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

10.10.2025 13:26 — 👍 225    🔁 60    💬 12    📌 5
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It is with great sadness that we heard of John Gurdon’s passing this week. Not just one of our 100 extraordinary biologists, but truly one of a kind, he was a pioneer, whose vision and personality inspired biologists worldwide.

10.10.2025 14:11 — 👍 30    🔁 5    💬 1    📌 0
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Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

10.10.2025 08:20 — 👍 139    🔁 147    💬 2    📌 2
Phd oportunity

Phd oportunity

Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social

www.colcc.ac.uk/2026-phd-pro...

crukradnet.colcc.ac.uk/phd-students...

09.10.2025 07:04 — 👍 6    🔁 10    💬 0    📌 0

Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14!
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...

09.10.2025 08:57 — 👍 9    🔁 4    💬 1    📌 0

We're funding doctoral programmes to train the next generation of clinically-active academic leaders. 🩺

This call continues our commitment to supporting healthcare professionals in research careers.

Applications are open now. Here’s what you need to know 🧵

08.10.2025 16:04 — 👍 8    🔁 12    💬 1    📌 0
Black and white portrait of John Gurdon, 1971

Black and white portrait of John Gurdon, 1971

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

08.10.2025 08:49 — 👍 99    🔁 32    💬 3    📌 3
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

07.10.2025 16:02 — 👍 187    🔁 100    💬 7    📌 7
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John Gurdon John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...

“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”

He proved them wrong! RIP John Gurdon

www.cell.com/current-biol...

07.10.2025 16:21 — 👍 36    🔁 14    💬 0    📌 2
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Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s

06.10.2025 10:52 — 👍 121    🔁 40    💬 2    📌 4

Latent plasticity of the human pancreas across development, health, and disease. https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1

03.10.2025 14:34 — 👍 4    🔁 2    💬 0    📌 0
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Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375 The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

10.03.2025 23:48 — 👍 20    🔁 23    💬 0    📌 1
A visual featuring a black-and-white photo of Marie Skłodowska-Curie. On the left, text reads "Choose EUROPE for Science." Below it says, "Marie Skłodowska-Curie Actions €22.5 million for researchers." On the right is the European Union flag with yellow stars on a blue background.

A visual featuring a black-and-white photo of Marie Skłodowska-Curie. On the left, text reads "Choose EUROPE for Science." Below it says, "Marie Skłodowska-Curie Actions €22.5 million for researchers." On the right is the European Union flag with yellow stars on a blue background.

#ChooseEurope for Science is live!

With €22.5 million under #MSCA, we’re funding organisations to:

🔬 Host postdoctoral researchers in all fields
🔬 Offer stable jobs and great working conditions
🔬 Create long-term career prospects

Europe is where science thrives.

More → link.europa.eu/6JhtHp

02.10.2025 08:23 — 👍 187    🔁 62    💬 3    📌 5
Research Associate: Human Lung Disease Mechanisms (Fixed Term) - Job Opportunities - University of Cambridge Research Associate: Human Lung Disease Mechanisms (Fixed Term) in the Gurdon Institute at the University of Cambridge.

Looking forward to working with new colleagues on a collaborative project in lung disease modelling and transcriptomics - please share! And email Jenny @jennydickens41.bsky.social, or me, with any questions. 😀

www.jobs.cam.ac.uk/job/52936/

02.10.2025 15:14 — 👍 7    🔁 9    💬 0    📌 0

Merci @shukryjhabib.bsky.social for the fabulous meeting and great hospitality in Lausanne ! 🧪🧫🔬🎶
Looking forward to the next #L2RM!

30.09.2025 19:26 — 👍 0    🔁 0    💬 0    📌 0

Congratulations Sara 🎉 ! This is a really interesting and elegant study !!!

29.09.2025 20:59 — 👍 1    🔁 0    💬 1    📌 0

🚀 Exciting news!

Islet Biology is back @keystonesymposia.bsky.social !!!
Don’t miss the chance to register for this exciting conference!

🚨Early-bird registration is NOW OPEN --- see below ⤵️
#KSDiabetes26 🌲🌲🌲

25.09.2025 08:42 — 👍 3    🔁 2    💬 0    📌 0

🚀 Exciting news!

Islet Biology is back @keystonesymposia.bsky.social !!!
Don’t miss the chance to register for this exciting conference!

🚨Early-bird registration is NOW OPEN --- see below ⤵️
#KSDiabetes26 🌲🌲🌲

25.09.2025 08:42 — 👍 3    🔁 2    💬 0    📌 0

Congratulations Alexis!!! 🎉🎉

22.09.2025 14:54 — 👍 1    🔁 0    💬 1    📌 0

Side hustle level-up! My book, IN THE BEGINNING, will be published by @harperonebooks.bsky.social in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going.
@harpercollins.bsky.social (1/2)
@socdevbio.bsky.social
#devbiol
#scicomm

15.09.2025 15:38 — 👍 85    🔁 15    💬 6    📌 4
Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

15.09.2025 09:26 — 👍 92    🔁 100    💬 0    📌 4
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Vancouver Coastal Health Research Institute (@vchresearch.bsky.social) Vancouver Coastal Health Research Institute — Leading innovative research with health impact in Canada. vchri.ca

Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social

14.09.2025 09:49 — 👍 14    🔁 7    💬 1    📌 1
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Computational image analyst (m/f/d) The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

12.09.2025 06:17 — 👍 87    🔁 86    💬 1    📌 1
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Edith Heard life lessons Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.

Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.

www.crick.ac.uk/news/2025-09...

10.09.2025 13:32 — 👍 49    🔁 13    💬 2    📌 0
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Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4

lnkd.in/eUKd4zxh

08.09.2025 19:42 — 👍 10    🔁 3    💬 1    📌 1
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Faculty recruitment - Our Scientists Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.

Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.

Learn more below:

20.08.2025 15:13 — 👍 19    🔁 20    💬 0    📌 1
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Edith Heard

Exciting day for @crick.ac.uk today: Edith Heard takes over as Director

We're looking forward to this new chapter in the story

www.crick.ac.uk/about-us/lea...

01.09.2025 05:39 — 👍 92    🔁 20    💬 1    📌 1

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

25.08.2025 20:03 — 👍 23    🔁 31    💬 0    📌 0

@labspagnoli is following 20 prominent accounts