Sandeep Thekkepat

Great ideas!

Persistent C-peptide secretion is associated with favourable CGM metrics in adults with type 1 diabetes - Diabetologia Aims/hypothesis Residual endogenous insulin secretion, reflected by measurable C-peptide, has been linked to improved glycaemic management in type 1 diabetes. We aimed to assess the relationship betwe...

Our new paper in @diabetologiajnl.bsky.social shows persistent C-peptide secretion is associated with favourable CGM metrics - relevant threshold appears to be ~50pM @shareenforbeslab.bsky.social

link.springer.com/article/10.1...

Not good for the staff who will lose their jobs. The management have been negligent with scant regard for patients and professionals. Just focussed on share price 🤷🏼‍♂️ Supply chain issues, arbitrary withdrawal of insulins etc. Patent renewal shouldn’t happen and generics should come on board soon.

The latest 2025 #Hypertension Guidelines are out 📣
#Nephpearls #NephSky

📌 On checking Office and Home BP

👉🏼 pubmed.ncbi.nlm.nih.gov/40811516/

The treatment of TB goes way beyond access and affordability of medications.
Book Club for #NephJC
Evething is Tuberculosis @johngreensbluesky.bsky.social
Discuss 8/19/25 9pm EST

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Agree totally. It’s his choice. Rest should chill. Good on him.

One way to defeat AI in the future 😉 Paging John Connor!

As usual I can’t say enough good things about @ukkidney.org guidelines - their flozin one is fantastic, and I’m pleased to say their clear summary is supportive of this practice👇

While in Scotland .......... 🤷

Shoutout to reading.

The @americanheart.bsky.social just published their alcohol recommendations today which line up with the report by National Academies. Moderate EtOH intake, up to 7 drinks per week (1/day), is without risk (and may be beneficial for cardiovascular outcomes)
www.ahajournals.org/doi/10.1161/...

it’s time to replace all doctors with ai

RFK Jr threatens ban on federal scientists publishing in top journals US health secretary calls leading medical journals such as Lancet ‘corrupt’ and pushes to create state-run alternatives

The news keeps on coming! www.theguardian.com/us-news/2025...

Opinion | All the President's Enablers Three books on Joe Biden’s presidency jointly paint a devastating portrait of an ailing, geriatric leader surrounded by mendacious aides and grasping family members.

This is perhaps the best essay on this sad and fateful mess www.politico.com/news/magazin...

In September, 2024, physicians working with AI did better at the Healthbench doctor benchmark than either AI or physicians alone.

With the release of o3 and GPT-4.1, AI answers are no longer improved on by physicians

Error rates appear to be dropping for newer AI models. openai.com/index/health...

Anyone invent a gadget that I wear and none of the smart glasses or any wearable with a camera can see me! Just a blob. and maybe shoot a laser if I am really pi**ed off 😉. I’ll buy it.

That’s the U.K. price! £9k is mad.

Hospital Anxiety and Depression Scale (HADS) eprovide.mapi-trust.org/instruments/...

Someone outside US should do this! 😉 just to drive Trumpers mad!

I am sure another site can do this!

That’s where one needs to be paid. Refuse if Journal can’t pay.

Diagnosing arginine vasopressin deficiency and primary polydipsia A crucial step in evaluating hypotonic polyuria and polydipsia is distinguishing between the rarer, potentially life-threatening arginine vasopressin deficiency and the more common primary polydipsia,...

Also read the linked comment by Kay Weng Choy & Cherie Chiang:
Diagnosing arginine vasopressin deficiency and primary polydipsia www.thelancet.com/journals/lan...
#diabetes #insipidus
#MedSky #EndoSky #NeuroSky
#FREE to read with registration (also FREE)

A novel diagnostic score for diagnosing arginine vasopressin deficiency (central diabetes insipidus) or primary polydipsia w/ basal laboratory parameters & a novel diagnostic score: results from two international multicentre prospective diagnostic studies www.thelancet.com/journals/lan... #EndoSky

Worse than Sony’s naming convention for headphones 😉

Time for #Calexit 😉

If ever.

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org
www.nejm.org/doi/full/10....

An AI tool to diagnose chronic obstructive pulmonary disease (COPD) is due to be rolled out to the NHS, offering patients an alternative to traditional spirometry.

Full story 👉 ow.ly/xf7550VtGRS

a low renin, especially a low renin while on a medication known to raise renin (ACEi/ARB/MRA/ENaCi) is likely some degree of primary aldosteronism. Either way, a phenotype that will respond to MRA therapy very well