This is my new wish, sending it out into the universe:
An artificial intelligence platform to simulate human biological responses to an experimental treatment, from phase 1 to phase 4 of clinical trials. 🧞♂️
Could boron cluster anions
Def: a technique to bring functional proteins into cells, gently and without damaging membranes and was tested on simple proteins.
be used with CRISPR-Cas9 (gene-editing molecular scissors)? 🤔 And could it be tested or modeled in silico?
I’ll try to write my first article about my project Modeling Cellular Homeostasis and Longevity and publish it on arXiv. (I’m supposedly on a break, but it feels more like I have to work twice as hard!😅)
💡This direct conversion method offers a promising alternative to traditional approaches involving iPSCs, simplifying the process and reducing the risks associated with cellular differentiation. 💡Could the same process be done for other critical cells involved in longevity? 🤔🤩
Autologous therapies could be the key to biological replacement, very interesting news! 🤩🤩 👏👏👏
They converted a single skin cell into over ten differentiated neurons, which integrated into the host tissue after implantation in mice. news.mit.edu/2025/mit-eng...
This model could help identify the most practical/easiest modifications.
To scientifically validate the accuracy of our model, we plan to test it against large datasets from thousands of mammals and animals. By comparing the model’s predictions with real biological data. 3/3
to identify homeostatic strategies (biological balance) that promote longevity.
AND…🧐
To assess how this model applies biologically.
Key insight: If different pathways lead to the same result, some cellular modifications in humans may be easier to apply.
Why it matters…2/3
Here is what we are currently working on and why:
Modeling cellular homeostasis and longevity through a mathematical model integrating multiple biological parameters:
- telomere length
- DNA repair
- immune function
- cellular metabolism
- oxidative stress
The goal is… 1/3
The potential of these cells is immense, and we are excited to continue this research. (10/10)
For those who want to delve deeper into the topic, here are the two recent studies that have influenced our research:
Study 1: MSCs and knee regeneration
journals.sagepub.com/doi/10.1177/...
Study 2: MSCs and optic nerve repair in glaucoma
journals.sagepub.com/doi/10.1177/...
(9/10)
We are now exploring how far MSCs can go in rejuvenating different parts of the body. Their immune compatibility and regenerative power make them truly fascinating!
Regenerative medicine is evolving fast! MSC research brings us one step closer to future breakthroughs in healing and longevity.(8/10)
What’s remarkable is that MSCs don’t just replace damaged cells, they stimulate repair and regeneration, particularly in nerve-related injuries. Their potential in neurodegenerative diseases is fascinating! (7/10)
Another study suggests that MSCs could be a safer approach than epigenetic reprogramming to slow glaucoma progression and support vision. However, they don’t restore vision in the same way. (6/10)
In this study, the MSCs were even genetically modified to treat a specific condition.
But what interests us the most is that they were rejuvenated before being reintroduced into the body. This opens up incredible possibilities. (5/10)
MSCs have been studied for knee repair! One study showed that injecting MSCs into damaged joints promoted cartilage regeneration and improved mobility.
The results showed improved joint function and reduced pain. (4/10)
One amazing property of MSCs: they bypass the immune system! This means donor stem cells can be used without major rejection risks, making them ideal for regenerative medicine. (3/10)
I truly admire your work! 👏👏
MSCs can be obtained from umbilical cords or grown in labs, but most studies use umbilical cord MSCs for a simple reason: they are more cost-effective.
What makes them truly fascinating is how they interact with the human body. (2/10)
Exciting news from our research on mesenchymal stem cells (MSCs) and their potential for rejuvenation. Recent studies on these cells have helped advance our work on their regenerative applications.
Here’s why these discoveries are so important. (1/10)
Hi! 🙃
My @stanfordhai.bsky.social colleagues and I predict #AI trends in 2025 hai.stanford.edu/news/predict...
My take: we will see many more multi-agent AI teams, instead of individual models, for tackling complex problems like those in science.
3/3 I was thinking that if we could reintroduce younger cells into our body from rejuvenated stem cells, we could also, with these kinds of minimally invasive technologies, target and destroy older cells. But, well, I said this without having investigated the matter in detail. 🤷♀️🙃😉
2/3 For instance, in cases of significant weight loss. Of course, clinical trials would likely be necessary to explore this possibility, and the process would probably be quite complex. Worth investigating? 🤔
The NanoKnife is a “almost” none invasive technology designed to destroy cancerous cells. An idea came to mind— I wondered if this technology could potentially be applied in aesthetics to target and eliminate excess skin cells. 1/3
www.bbc.com/news/article...
Very interesting!
To be able to live young and eternally, or at least until we feel it’s time for it to end, wouldn’t that be an immense treasure? Idk why they don’t see that. And I know it’s possible, we just have to work on it.
Me in @wired.com: Antibodies could soon help slow the aging process www.wired.com/story/antibo...
There have been several cool antibody papers recently, and the one where antibodies cleared out aging blood stem cells was particularly amazing. Check out the piece for more!
Two great lists if you’re looking to connect with folks in #AgingResearch
-1/3-
Here is my up-to-date Rejuvenation Project (priority on point 4):
1- Extract a skin cell.
2- Rejuvenate the cell through somatic cell nuclear transfer (SCNT) mainly to rejuvenate the cytoplasm.
3- Convert the rejuvenated cell into a specific stem cell (details in appendix).
This starter pack is intended for researchers in all areas of sensorimotor control - just let me know if you would like to be added. go.bsky.app/VSH9DwK
