JStark lab

Check this out 👇👇👇

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes - Nature Communications DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

📢📢Apply now for GRS/GRC on DNA Damage Mutation & Cancer in sunny Ventura CA.

This data is really striking - mRNA vaccine priming ICI response in several tumors

YouTube video by Senator Chris Van Hollen Kicking off No Kings Day with fired up patriots at NIH

Today I kicked off No Kings Day with hundreds of fired up patriots at NIH who are standing up to this lawless president.

Together we said NO to his attacks on public health.
NO to his assault on our Constitution.
NO to kings in America.

And YES to standing up for our democracy.

No Kings! In Pasadena

SoCal Genome Stability Symposium The annual Genome Stability Symposium provides a forum for trainees in the Southern California region to present their research on the field of genome stability.

Registration is open for the 2025 SoCal Genome Stability Symposium. Free registration. All talks by trainees. www.cityofhope.org/genome-stabi...

www.nature.com/articles/s41... saw @lablegube.bsky.social present this last week. Provides important clarity on RNA at chromosomal DSBs. Including rigorously debunking the nascent synthesis idea.

Exciting to have 3 days to focus on this pathway.

It’s been a long time coming! Grateful to all co-authors and colleagues who supported this study, especially @yilanfan.bsky.social 🙌 We have been working on this complex for nearly 3 years together and finally managed to tame it. MRN gave us Many Restless Nights, but we’re More Relaxed Now 😎

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements https://www.biorxiv.org/content/10.1101/2025.09.17.676864v1

I’m using this icon for my talk at nhej2025.sciencesconf.org
Guess the topic

Gearing up to head to Paris for nhej2025.sciencesconf.org but indulging in some LA delicacies before I go.

I’ve met many raw milk is healthy, we already have the cure for cancer, immunizations are dangerous, HIV isn’t the cause of AIDS people. As a scientist I thought it important to counter with respect and logic, and wonder how we are failing at public health. No more. New response - “that’s stupid!”

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Postdoctoral Training Programs Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

this is so wonderful and so critical right now

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicine—Basic Sciences

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...

Automated machine learning profiling with MAP-HR for quantifying homologous recombination foci in patient samples Abstract. Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for

Beyond BRCA status: machine-learning assisted multichannel imaging platform for cell-by-cell analysis of HR competency, enabling patient stratification. “Editor’s Choice” in NAR Cancer. academic.oup.com/narcancer/ar...

NAR seeks a new Executive Editor Overview of the Journal Nucleic Acids Research (NAR) is a leading open access molecular biology journal published by Oxford University Press. It provides rapid

Our sister journal, Nucleic Acids Research, has opened a search for an Executive Editor. Great opportunity for mid-career or senior investigator looking to be part of a great team, handle 100-150 papers per year, and attend the annual EE meeting. Details at: academic.oup.com/nar/pages/ex...

Fingers crossed 🤞

Yeah…10% was bad enough…

I was thinking about this too as I'm a standing member at NIH and review did the DoD. The amount of time and effort for no monetary benefit that is expected of us is unreasonable even at a 10th percentile funding rate. But at 4%.... what are we even asking of scientists?

4% payline demoralizing for reviewers - review 9 grants each taking 3-4hrs (total reviewed by all is 90) flying to DC, a hotel conference room to discuss the top half of grants (45) 15 min each, 3x a year for 4 yrs. Paid $300. 4% = maybe 3/90, 0-1 that you reviewed funded. I couldn’t.

From cooperation to conflicts – a complicated relationship between transcription and replication. A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...

😢 RIP. Still to this day my favorite experiment in molecular biology.

Dynamic assemblies and coordinated reactions of non-homologous end joining - Nature Structures associated with the final steps of non-homologous end joining (NHEJ) and gap filling present new targets for NHEJ inhibition to enhance efficacy of radiotherapy and accuracy of gene editing...

Excited this study is out - we helped with an experiment on Paxx www.nature.com/articles/s41...