👏Congrats to the whole team! Megan D. Joseph, Olivia LP Dalby, Rhian Walther, Karol Kołątaj, German Chiarelli, @fpichaud.bsky.social, Guillermo Acuna and Sabrina Simoncelli.
Special thanks to @healthcare.nikon.com and @lmcb-ucl.bsky.social Imaging facility for their support.
30.05.2025 15:17 — 👍 8 🔁 1 💬 1 📌 0
🔬 We believe this advancement will unlock new biological questions at scales and resolutions previously unattainable.
🧬 What systems would you explore with this level of detail?
30.05.2025 15:14 — 👍 3 🔁 0 💬 1 📌 0
✨ And yes—we go 3D.
We achieve:
✅ sub-10 nm localization precision at 9 μm depth in whole cells 🦠
✅ ~12 nm precision in complex tissues (like the Drosophila eye 👁)
Think about that: near-molecular detail, deep inside tissues.
30.05.2025 15:12 — 👍 2 🔁 0 💬 1 📌 0
✨ We push further:
🌈 Multicolour imaging and 🎯 #RESI = repetitive imaging → ultra-high resolution.
This opens complex multiplexed experiments inside cells, where precision matters.
30.05.2025 15:12 — 👍 2 🔁 0 💬 1 📌 0
✅ On a commercial microscope, we achieve sub-10 nm resolution on DNA origami across a 76 x76 μm2 field of view!
✅ We apply this in cells to resolve nuclear pore complex protein pairs inside the cellular context.
This is true protein-level imaging, across large scales.
30.05.2025 15:11 — 👍 2 🔁 0 💬 1 📌 0
