Ron Orbach

🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1

Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.

Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.

Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella

journals.biologists.com/jcs/issue/13...

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Grateful to @cilialab.bsky.social and @lottepedersen.bsky.social for curating this superb issue and for their dedication to advancing cilia research.

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Miao Gui and I wrote a Review for the @jcellsci.bsky.social special issue “Cilia and Flagella: From Basic Biology to Disease”. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts.

Microtubule inner proteins – bridging structure and function in ciliary biology Summary: Microtubule inner proteins (MIPs) have been brought into focus by the cryo-EM revolution. This Review outlines current knowledge, emerging functions, links to ciliopathies and outstanding que...

Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/article/...

Congratulations to our ISF 2025–2026 grant recipients from Bar Ilan’s Azrieli Faculty of Medicine in the Galilee: Dr. Liron Rosenkrantz, Prof. David Karasik, and Prof. Chaim Putterman.

Wonderful!! Congratulations!

Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀

Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:

journals.biologists.com/jcs/article/...

Cell state-specific cytoplasmic density controls spindle architecture and scaling Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨

👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

📣 Happy to share our review on host-microbiome genomics!

We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes

Out now in Nature Reviews Genetics👇

www.nature.com/articles/s41...

Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment - Nature Communications Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields and imaging depths, resolving...

Can we break past the usual limits of #SuperResolution #Microscopy—achieving deep-imaging, high-res, large FOV imaging without the trade-offs?
🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)!
📄 www.nature.com/articles/s41... @natcomms.nature.com!
🧵👇

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...

What a treat! After far too long, the lab finally took a break for some well-earned fun. We spent the morning biking through Agamon Hula, surrounded by beautiful scenery and nesting birds, and wrapped up with a delicious lunch. Here's to more outings like this in the future! 🚲

The Orbach Lab had a great time at the Annual Meeting of the Israel Society for Microscopy at Expo Tel Aviv.
Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community.
Big thanks to the organizers and everyone who stopped by!

What are you going to do with all the empty space - Asking for a friend....

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🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share

It was a real pleasure to present our work at The Biophysics of Motile Cilia – from Structure to Function meeting at the Physikzentrum Bad Honnef. Grateful for the fruitful discussions with both biologists and physicists, and for the opportunity to meet so many inspiring new colleagues.

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Evolutionary adaptations of doublet microtubules in trypanosomatid parasites The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet micro...

I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5

Lab's first published paper!! 🚨 We introduce Perceived Immunity (PI) - a new construct capturing perceived immune efficacy. Using a novel scale, we show that PI prospectively predicts physical symptoms up to 14 months later, beyond baseline symptoms.

Why is this important? Read on… 🧵

Fluorescence microscope image showing a protein that goes to only one flagellum

The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella

Dr. Moran Yadid is leading a groundbreaking international consortium with experts from Finland & Germany to develop an innovative personally tailored approach for treating heart muscle enlargement caused by a genetic mutation. The consortium operates under grant from the European Union.

‏How Do We Teach Doctors to Teach? We concluded a new & unique year-long course in medical education aimed to develop the teaching methods of clinical faculty. The course focused on teaching and assessment, emphasizing active learning, integrating theoretical knowledge, and working in small groups

‏Introducing the Tzafon Data and Bio-Bank - Israel’s first-ever bio-bank integrating biological samples and bacteria! this transformative bio-bank fueling both research and industry, is a collaboration with Tzafon Medical Center,To be led by Prof. Avi Peretz, Dr. Hagar Tadmor, and Dr. Maya Azrad.

Thank you for a fantastic talk Sahar! Fabulous story!

miRNA-target complementarity in cnidarians resembles its counterpart in plants | EMBO reports imageimagemiRNAs in plants and cnidarian animals operate similarly by binding their targets with nearly-full complementarity, in contrast to miRNAs in bilaterian animals that bind via a short seed-mat...

1/3 Our paper about miRNA target complementarity in Cnidaria is finally published in @emboreports.bsky.social This work was led by the talented Yael Admoni with help from Arie and Rubi in collaboration with the labs of @thecocodium.bsky.social and Michal Rabani
www.embopress.org/doi/full/10....