Alexander Stein

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?

Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. https://www.biorxiv.org/content/10.1101/2025.09.08.674950v1

Darwin's famous sketch of a rooted tree, representing speciation

New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.

Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14

arxiv.org/abs/2507.08615

In #GENETICS, @alexsteinresearch.bsky.social‬ and @benjaminwerner.bsky.social‬ present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/AE4sLUH

Interested in population genetics of cancer?

If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!

Lecturer in Applied Mathematics at City St George’s, University of London Apply for the Lecturer in Applied Mathematics role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

My department is hiring! Permanent faculty job (research + teaching) in applied maths. Mathematical biology would be highly appropriate. We're a friendly department in a large university in central London, recently merged with a big medical school. Apply by 1st June. www.jobs.ac.uk/job/DMY889/l...

Thank you David @cancerevo.org and Simone @zaccasimo.bsky.social for building my PhD viva panel! I enjoyed the discussions and appreciate your time and effort to assess my PhD.

And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!

Congratulations to a successful viva Dr. @alexsteinresearch.bsky.social

Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!

Tenure-Track Assistant Professor for Mathematical or Computational Ecology (80-100%) - Bern, Canton of Bern (CH) job with Institut für Ökologie und Evolution | 12834542 The Department of Biology at the University of Bern announces a vacancy for a Tenure-Track Assistant Professor to lead a new Division of Mathematic...

The University of Bern is looking for a Tenure Track Assistant Professor in Mathematical or Computational Biology: www.nature.com/naturecareer...

Congrats to all of you! 🥳

We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

📝New Author's summary about

"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak

and

"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak

Somatic mutation and selection at epidemiological scale As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Alex just dropped his magnus opus on BioRxiv

scholar.google.com/citations?vi...