Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...

My research is finally out!

Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way.

Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.

6/ ?translational substudies may be available. love to get the thoughts of SBRT experts like @gerryhanna.bsky.social @drewmoghanaki.bsky.social @mguckenberger.bsky.social

5/ Hypothesis - all work in vitro so far so lots of provisos - would be that tumours with HR defects would respond better to the combination of SBRT/SABR and immunotherapy.

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...

www.nature.com/articles/s41...

T brilliant team of scientists who did the work led by Radek, incl Sienna Casolin, Lucy French, @annagmanjon.bsky.social, @drmelaniew.bsky.social , Léa Cavalli, Chris Nelson, Scott Page, Andrew Dhawan, Eric Hau, Hilda Pickett, and of course @thecesarelab.bsky.social - great science and friendship

4/ We are grateful for much support. This project was not possible without @cmri.bsky.social, funding from NHMRC and ARC and longstanding support of the Western Sydney
Local Health District Radiation Oncology Network.

3/ This opens up new therapeutic opportunities to personalise the combination of SABR/SBRT and immunotherapy and run biomarker driven trials

2/ @thecesarelab.bsky.social has a wonderful run through of the science. Key take away for the rad onc community: timing and mode of cell death after ablative radiotherapy is dependent DNA repair pathway, with homologous recombination leading to mitotic 'non-immunogenic' cell death

1/ Thrilled that our paper is out today in @naturecellbiology.bsky.social. A collaboration between WSLHD Radiation Oncology Network and @thecesarelab.bsky.social @cmri.bsky.social, led by our very talented post doc Dr Radoslaw Szmyd