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Tony Cesare

@thecesarelab.bsky.social

Head of the Genome Integrity Unit, Children's Medical Research Institute. Professor, University of Sydney.

624 Followers  |  412 Following  |  108 Posts  |  Joined: 17.11.2024
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Posts by Tony Cesare (@thecesarelab.bsky.social)

@lisannes.bsky.social gave an outstanding seminar at @cmri.bsky.social yesterday.

Full room, exciting data, and a 15-minute Q&A -- a fantastic discussion.

Amazing work, Lisanne. Thank you for visiting and sharing it with the institute.

26.02.2026 01:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Delighted to host @cellpress.bsky.social editor Ilaria Carnevale today at @cmri.bsky.social for a seminar and meetings with our trainees and lab heads.

Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open.

Welcome to Australia, Ilaria. Thank you for visiting CMRI.

17.02.2026 22:54 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Cicada Innovations Cicada Innovations is Australia's leading incubator for startups and scaleups working on deep tech science and engineering innovations.

2026 @cmri.bsky.social seminar series starts today!

12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com

Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.

04.02.2026 00:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

3/Very grateful for the support of the NHMRC and our institutions. Excited to see this project, years in the planning, begin in 2026.

12.01.2026 01:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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2/Led by @hildapickett.bsky.social, with co-investigators @genomestability.bsky.social, @lisannes.bsky.social, Jacob Lewis, @yuhenglau.bsky.social, Sarah Henrikus, & the Cesare Lab, this project brings together expertise in telomere biology, DNA repair, biochemistry, drug discovery, & cell biology.

12.01.2026 01:50 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: β€œA mechanistic approach to developing precision therapies for ALT-dependent cancers.”

www.nhmrc.gov.au/funding/find...

12.01.2026 01:50 β€” πŸ‘ 19    πŸ” 4    πŸ’¬ 3    πŸ“Œ 0
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If I may be allowed a moment of fatherly pride.

Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship βšΎοΈπŸ‡¦πŸ‡Ί

A big achievement, especially in her first year of eligibility.

Baseball is awesome.

18.12.2025 10:33 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

3/ I’m relieved to have secured funding to sustain my lab, but am deeply concerned about the long-term health of Australia’s research sector. Our grant structures and peer review systems are in urgent need of reform.

18.12.2025 06:45 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

2/However, this is a bittersweet moment. With a success rate of just 8.1%, many excellent grants from brilliant researchers across Australia went unfunded. Not due to lack of quality, but because of an under-resourced, overstretched system burdened by inadequate and often inappropriate peer review.

18.12.2025 06:45 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate.

This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au

18.12.2025 06:45 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Collage of four people in a professional setting. Each person is wearing business-casual clothing, with backgrounds showing bright laboratory spaces and equipment.

Collage of four people in a professional setting. Each person is wearing business-casual clothing, with backgrounds showing bright laboratory spaces and equipment.

We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants

Tony Cesare

18.12.2025 05:38 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...

New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".

Happy our lab could play a small part.

Congrats Tracy, Ash Harman, Noa Lamm and the whole team.

www.nature.com/articles/s41...

03.12.2025 00:19 β€” πŸ‘ 22    πŸ” 13    πŸ’¬ 2    πŸ“Œ 0

Thank you @cmri.bsky.social for the nomination; @sydney.edu.au for this recognition; and our team for making this research possible.

27.11.2025 05:41 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.

27.11.2025 05:41 β€” πŸ‘ 11    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
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Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25.

Exciting science at a fantastic venue!

03.11.2025 11:53 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Delighted to be in beautiful Riviera Maya Mexico πŸ‡²πŸ‡½ for @fusionconf.bsky.social #SGO25.

www.fusion-conferences.com/conference/188

31.10.2025 16:10 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
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Anillin-dependent actin assembly at PML NBs protects genome stability | Noa Lamm I’m thrilled to share the first (!) pre-print from our lab, now available on bioRxiv: πŸ‘‰ Anillin-dependent actin assembly at PML NBs protects genome stability | bioRxiv This work was led by Vina De...

The study reveals how actin filaments form at PML nuclear bodies during replication stress and how this nuclear actin assembly protect the genome.

A summary of all manuscript details and the study participants can be found here: www.linkedin.com/posts/noa-la...

31.10.2025 16:03 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
| bioRxiv bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability
www.biorxiv.org/content/10.1...

Delighted our lab could play a role supporting Noa’s vision on this project.

31.10.2025 16:03 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0

Our project uses telomeres to model how homologous recombination influences cell death & proliferation.

The Pickett–Giles project investigates 3D chromatin architecture in DNA repair.

Thank you @cmri.bsky.social, @sydney.edu.au, and the Australian government for supporting basic research.

31.10.2025 15:35 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week.

I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells

31.10.2025 15:35 β€” πŸ‘ 12    πŸ” 1    πŸ’¬ 2    πŸ“Œ 1
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The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne.
australiancellcycle.org

A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting.

We're looking forward to 2027!

22.10.2025 23:55 β€” πŸ‘ 18    πŸ” 3    πŸ’¬ 1    πŸ“Œ 2

Simon is internationally recognised for pioneering discoveries in DNA repair, genome stability, and telomere biology. His lab’s work continues to redefine how we understand chromosome maintenance and cancer biology.

Join us at 12:30 for what promises to be an excellent talk!

22.10.2025 23:38 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social.

Simon will present β€œMaking T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.

22.10.2025 23:38 β€” πŸ‘ 13    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness".

If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!

16.10.2025 06:07 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.

11.09.2025 08:35 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸ“’Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➑️https://bit.ly/3JJzYR4

02.09.2025 14:34 β€” πŸ‘ 0    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

Lovely work Pragathi!

06.08.2025 00:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!

06.08.2025 00:55 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
A person seated in a laboratory setting with shelves, containers, and scientific equipment in the background.

A person seated in a laboratory setting with shelves, containers, and scientific equipment in the background.

We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.

17.07.2025 06:59 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
DNA-repair-driven cell death compels us to rethink cancer therapies - Nature Reviews Molecular Cell Biology Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

04.08.2025 05:48 β€” πŸ‘ 25    πŸ” 9    πŸ’¬ 1    πŸ“Œ 1