Kyojiro N Ikeda

Membrane morphologies arising from multiconformational protein states Dynamic compartmentalization by lipid membranes is a hallmark of living cells. The shapes of membrane surfaces are tightly coupled to their various functions, resulting in the myriad of complex membra...

www.cell.com/biophysj/abs...

Structure and assembly of the A-C linker connecting microtubule triplets in centrioles Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage Using precise tissue volume quantification, El Marzkioui, Gaugué, et al. show that wing primordia continue to grow during the early pupal stage, a phase of increased cell volume driven by insulin/IGF ...

Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest.
With @leopoldlab.bsky.social
www.cell.com/current-biol...

This creature can 3D-print its own body parts Bristle worms have protrusions that act like a 3D printer, helping us to understand how cells regenerate.

Out stody Is now on National Geographic!!!

www.nationalgeographic.com/animals/arti...

Very proud to share our latest preprint: postdoc/LRSF fellow Yue Rui studies the mechanisms regulating attachment of the cell wall to the plasma membrane. The Cellulose Synthase Complex and REMORINs determine the extent of attachment and root osmotic stress tolerance. www.biorxiv.org/content/10.1...

An amoeba with teeth. When building its shell, Netzelia corona selects sharp grains of quartz and positions them around its aperture with the tips pointing inward. I took a few closeups, yesterday. #ProtistsonSky #amoebae #peatlands #MEvoSky

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
elifesciences.org/articles/931...

Belyantseva and Liu et al. report that taperin encircles and stabilizes F-#actin at auditory hair cell #stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, and other abnormalities culminating in deafness. rupress.org/jcb/article/...

I can say that I lived in the times of CRISPR. - @jenniferdoudna.bsky.social 's talk at @gmivienna.bsky.social 25th year anniversary jubilee at ÖAW.

Work for us Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...

#DevBio job opportunity!

Development (@dev-journal.bsky.social) is looking for a new Community Manager to run our community site, the Node (@the-node.bsky.social) – a great opportunity if you love devbio, #stemcells, #scicom and community engagement. Happy to chat informally about the role.

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I’ve just updated the BioEmu notebook to include the powerful LogMD. Now, you can generate equilibrium ensembles and explore the full ensemble directly in the notebook.

A huge thanks to Alexander Mathiasen for the support! 🙌

🔗 Try it on Google Colab: lnkd.in/gcuqd-fT

Kyojiro Ikeda @beingkyo.bsky.social @univie.ac.at presenting now at #DevStem2025 @viennabiocenter.bsky.social on first mechanistic & molecular regulators of #bristle biogenesis in the #Platynereis model. Also check Kyojiro's recent @naturecomms.bsky.social publication www.nature.com/articles/s41...

Are you in for a PhD project on neural #regeneration? Only 2 more weeks to apply to the @vbcscitraining.bsky.social @univie.ac.at VBC PhD programme: vbcphd.at ! Pls. see tiny.cc/RaibleLab and our recent @naturecomms.bsky.social study www.nature.com/articles/s41... for information and contact!

Open positions Open positions

Take the next step in your academic career and become part of a thriving international research community!
The Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (VDS-PhaNuSpo) are offering 13 fully four-year funded PhD positions at the moment!

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

https://go.nature.com/4hrHX0v

My continued biological education
#Mechanobiology #RigiditySensing

Stiffness Sensing by Cells

"Substrate Stiffness Can Lead to Heritable Epigenetic Changes"

"Cell Motility Is Faster on Soft Elastic Substrates"

#PhysiolRev 2020
journals.physiology.org/doi/full/10....

Cool story on nanopatters! We had picked Osiris genes as erect wing regulated, but no clue what this was about.
genomebiology.biomedcentral.com/articles/10....

Can you spot the difference? 🔬
SiR-actin labeling can be cytotoxic and affects actin dynamics - while the new XActin probes do not! Developed by @veselin-nasufovic.bsky.social and perfect for time-resolved and STED imaging without the need for genetic manipulation.
www.biorxiv.org/content/10.1...

First Post! Thrilled to share our lab's first evolutionary cytoskeleton study! We uncover two distinct FtsZ paralogs in Odinarchaeota OdinFtsZ1 forms curved filaments, while OdinFtsZ2 assembles into spiral rings. A glimpse into tubulin evolution! threads👇 #Eukaryogenesis #AsgardArchaea #cytoskeleton

Huge congrats to Nadja Milivojev @vbcscitraining.bsky.social who successfully defended her @univie.ac.at PhD thesis with a brilliant presentation today. Thanks to examiners Elly Tanaka, Michael @mikebok.bsky.social and Roger Revilla, and both labs for wonderful support!

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

Microscopic pillars on insect wings give bugs an antibacterial superpower New insights into how these “nanopillars” work could inspire better ways to protect humans from infection

Cicadas have little, bendy micro-pillars on their wings that pierce bacterial membranes and are as effective at killing microbes as a bleach solution. It might be possible to mimic this effect for use in medical (etc.) equipment. 🪳🪲🧪

www.science.org/content/arti...

Sell patent to a company.

Banner for the SY-Stem meeting in Vienna, Austria, March 12-14, 2025

#SYStem2025 :: Vienna, March 12-14 :: #StemCell niches | Deterministic v. stochastic decisions | Germline | Stem cell model systems | #Epigenetics & imprinting | Cell biology of Stem Cells | Transitioning Stem Cells into the clinic; For oral presentations, register by Jan 15! www.sy-stem.org

A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heter...

📜 A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids

🧑‍🔬 Adam Jozwiak, Asaph Aharoni, et al.

📔 @science.org

🔗 www.science.org/doi/10.1126/...

#️⃣ #PlantScience #PlantImmunity #PlantMetabolites