Thomas Wolfers

Poor image quality introduces systematic bias into MRI data Analyses that include low-quality MRI data underestimate cortical thickness and overestimate surface area, according to new work from the ABCD Study.

Big data won't solve anything if it's crappy data. 😒

We need to 1) train people to inspect datasets before using them and 2) ensure that openly shared data is good data.

www.thetransmitter.org/spectrum/poo...

Eye puffs prompt separable sensory, affective brain responses in mice, people Post-puff brain state might not be an emotion, some researchers caution, but the protocol provides a cross-species approach to study emotions.

A cross-species study captured an emotional brain state characterized by lingering brain activity in higher-order areas. “It’s one of those moments where you’re getting a first glimpse at a vast and complex landscape,” says @deisseroth.bsky.social.

By @callimcflurry.bsky.social

bit.ly/3U33raF

Work by Tara Arbab, Ingo Willuhn et al. on neural biomarkers in OCD was published in Nature Mental Health.🗨️Arbab about the study: "It's unique that we were able to measure deep brain activity with very high spatial and temporal precision.” @willuhnlab.bsky.social www.amsterdamumc.org/en/research/...

SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19: cohort study - Nature Communications SARS-CoV-2 rebound is a recurrence of symptoms or return to test positivity after initial recovery. Here, the authors demonstrate an association between SARS-CoV-2 rebound and post-acute COVID conditi...

www.nature.com/articles/s41...

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Brain–computer interface restores naturalistic speech to a man with ALS Nature Reviews Neurology, Published online: 08 July 2025; doi:10.1038/s41582-025-01122-6A voice-synthesis neuroprosthesis based on a brain–computer interface has restored instantaneous, natural-sounding speech to a man with amyotrophic lateral sclerosis.

ICYMI: New online! Brain–computer interface restores naturalistic speech to a man with ALS

Self-supervised predictive learning accounts for cortical layer-specificity - Nature Communications How the cortex learns an internal representation of the world and why the cortex relies on a layered structure remain poorly understood. Here, the authors propose a computational theory in which the n...

Pleased to say that our story of how a theory of self-supervised learning in cortical layers accounts for several experimental observations is now out 🎉
www.nature.com/articles/s41...

Rethinking excitation/inhibition balance in the human brain - Nature Reviews Neuroscience The balance between neural excitation (E) and inhibition (I) shapes cognition, development and brain-based disorders. Electroencephalography and magnetic resonance spectroscopy allow non-invasive quan...

Rethinking excitation/inhibition balance in the human brain — a Comment article by Roi Cohen Kadosh

#neuroscience #neuroskyence

www.nature.com/articles/s41...

I defended my PhD! You can watch it on YouTube here: youtu.be/OCfqTtPy1KM?...

David Leeftink's first PhD thesis work is now available on arXiv! Probabilistic Pontryagin's Maximum Principle for Continuous-Time Model-Based Reinforcement Learning, check it out!

Cerebellar circuit computations for predictive motor control - Nature Reviews Neuroscience The cerebellum helps ensure the speed and accuracy of movements, but its precise contributions to movement control are unclear. Nguyen and Person here evaluate evidence for and against feedforward mot...

Cerebellar circuit computations for predictive motor control — a Review by Katrina P. Nguyen & Abigail L. Person

www.nature.com/articles/s41...

#neuroscience #neuroskyence

New online! Influence of sleep and chronotypes: are we adapted to today’s society?

Congratulations @Saige to a wonderful PhD Defense!

Noninvasive reduction of neural rigidity alters autistic behaviors in humans - Nature Neuroscience Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is ‘stuck’ in a certain state reduces this rigidit...

Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is ‘stuck’ in a certain state reduces this rigidity and relieves various autistic traits.

@takamitsuw.bsky.social

www.nature.com/articles/s41...

🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.

Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3

www.medrxiv.org/content/10.1...

Check out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features Cerebellar normative features as predictor of disorders Mental and neurological conditions have been linked to structural brain variations. However, aside from dementia, the value of brain structural charac…

Congratulations to Milin Kim for the acceptance of her paper.

www.sciencedirect.com/science/arti...

Autonomic physiological coupling of the global fMRI signal - Nature Neuroscience The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

Widespread cofluctuations in the low-frequency range between resting-state global fMRI signals, EEG activity, and a host of peripheral autonomic signals spanning cardiovascular, pulmonary, exocrine and smooth muscle systems 🧪🧠

www.nature.com/articles/s41...

Bilateral integration in somatosensory cortex is controlled by behavioral relevance - Nature Neuroscience How sensory signals from both sides of the body are integrated into a single percept is not well understood. Park et al. show that callosal signaling supports the integration of bilateral tactile stim...

Bilateral integration in somatosensory cortex is controlled by behavioral relevance 🧠🧪

@scottrpluta.bsky.social

www.nature.com/articles/s41...

Data Sharing - ABCD Study

FYI, if you want to be prepared to apply for the next ABCD Study data release, prepare for these new NIST security requirements 🧠: @ohbmofficial.bsky.social abcdstudy.org/scientists/d...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Info theory offers powerful measures for capturing complexity & interaction among elements of a complex system, like the brain! 🧠 Here's our new unified reference for key info-theoretic time series measures ft. 📊 visuals, ➗equations, & 💬descriptions:

arxiv.org/abs/2505.13080

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets Linear mixed-effects (LME) models are commonly used for analyzing longitudinal data. However, most applications of LME models rely on random intercepts or simple, e.g., stationary, covariance. Here, w...

Introducing FEMA-Long for high-dimensional large-scale mixed-effects modelling! Includes modelling unstructured covariance, non-linear effects using splines, time-dependent effects with spline interactions, and longitudinal GWAS with time-dependent genetic effects!
www.biorxiv.org/content/10.1...

New paper in Imaging Neuroscience by Paige Howell, Sanne Kikkert, et al:

Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI

doi.org/10.1162/imag...

Looking for automated brain extraction tools that are:

- Quick and easy to install.
- Without "ugly" dependencies (big toolboxes, containers, matlab, etc).
- Easy to use.
- Quick to run (1/2 minutes).
- Not ROBEX, SynthStrip or FSL's BET (we already tested those).

Bluesky, do your magic!

Thanks!

I look forward to presenting and discussing this work www.pnas.org/doi/10.1073/... in the Soft Matter and Biophysics Seminar of the Institute of Theoretical Physics at the Chinese Academy of Sciences! More info and link to join here: english.itp.cas.cn/activities/T...

YouTube video by Eurovision Song Contest KAJ - Bara Bada Bastu (LIVE) | Sweden 🇸🇪 | Grand Final | Eurovision 2025

Very happy to see Eurovision Song Contest. Too bad that Sweden did not win, they kept up the good old tradition, w.r.t. ESC songs, and on top sang about “Saunas”. Miss the fjord Saunas in Oslo, albeit not in Sweden, a great start to the day!

youtu.be/WSh7U3m9KgA

Adversarial testing of global neuronal workspace and integrated information theories of consciousness - Nature Multimodal results (iEEG, fMRI and MEG) of predictions from integrated information theory and global neuronal workspace theory align with some predictions of both theories on visual consciousness, but also critically challenge key tenets of both theories.

Nature research paper: Adversarial testing of global neuronal workspace and integrated information theories of consciousness.

https://go.nature.com/3Ylq4d6

Principal Investigator positions at ELLIS Institute Finland | ELLIS Institute Finland Now recruiting new PIs in artificial intelligence and machine learning

🎇 This is your opportunity to be part of something groundbreaking: join the newly established @ellisfinland.bsky.social 🇫🇮 as a Principal Investigator. Applications are encouraged in all areas of #MachineLearning, #AI, and related disciplines. www.ellisinstitute.fi/PI-recruit

An image shows two firefighters with shovels on top of a torn-down building. One is overlayed in yellow, the other in blue. The words "United in diversity" are at the top left corner, and the European Commission logo is in the bottom right corner.

There is no space for racism in the EU.

No one should be denied a job, home, or opportunity because of their race or ethnic background.

On International Day for the Elimination of Racial Discrimination and every day, the EU stands united against racism, for a #UnionOfEquality.