Epelmanlab

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JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Job alert 🚨!
If you are looking for a post-doc in cell engineering, macrophage biology, 🫀 regenerative medicine - we are hiring! Toronto is a great city to launch your career!
jobs.smartrecruiters.com/UniversityHeal…
@uhnresearch.ca @stemcellnetwork.ca

More great content from @preprintclub.bsky.social @epelmanlab.bsky.social. This @biorxiv-immuno.bsky.social preprint from Liu et al. reports that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure.

Matrix-producing neutrophils populate and shield the skin Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

📢Next joint CRC/IRTG 1123
🧑‍🏫Seminar Series next week 🗓️ @dfg.de @lmumuenchen.bsky.social

🗣️ Slava Epelman @epelmanlab.bsky.social @uhnresearch.bsky.social @uoft.bsky.social @trogersresearch.bsky.social

📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages

tinyurl.com/rd9ayw56

Proposed role of itching: MgrpA3 expressed on itch sensing neurons triggers the itching sensation. Scratching then activates pain-sensing neurons via TRPV1, which in turn release substance P. Substance P then activates mast cells to release more pruritogens (agents that cause itching) and pro-inflammatory molecules that enhance host defense against Staphylococcus aureus. The mast cell is also activated by allergens which crosslink IgE on its surface, promoting mast cell degranulation.

If you have ever wondered why we scratch itchy things... we have a new answer for that question: it promotes clearance of Staph bacteria on the skin via activation of mast cells.

www.science.org/doi/10.1126/...

We've summarised the landscape of human pluripotent stem cell trials worldwide in a review in Cell Stem Cell. Fun fact: Over 1200 patients have to date received treatment with hPSC products in 116 different trials, and more than 100 billion hPSC-derived cells have been dosed! doi.org/10.1016/j.st...

A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls

www.nature.com/articles/s41...

Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior Immune activation is often thought to exacerbate stress-related mental disorders. Here, Xia, Lu, Lan, et al. reveal elevated IL-22 derived from the gut during the early phase of repeated stress. IL-22...

I certainly didn't have IL-22 on my bingo card as an anxiolytic (anti-anxiety) factor
#Immunosky
www.cell.com/immunity/ful...

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov

Kevin Hall: What Should We Eat? Insights from the research by a leading scientist in nutrition and metabolism

What should we eat? Or avoid?
The new Ground Truths podcast is with @kevinh-phd.bsky.social, a leader in nutrition science and metabolism
erictopol.substack.com/p/kevin-hall... Full transcript with links to multiple publications

Haematological setpoints are a stable and patient-specific deep phenotype - Nature Complete blood count indices are tightly regulated around setpoints for decades in healthy adults, and represent a deep phenotype providing opportunities for investigating differential disease risks, ...

Neat! www.nature.com/articles/s41...

A prenatal skin atlas reveals immune regulation of human skin morphogenesis - Nature A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including the formatio...

Fantastic paper by @mhaniffa.bsky.social @humancellatlas.org
www.nature.com/articles/s41...

We know #macrophages are versatile but inducing skin vascularisation! 🤩
#immunosky #medsky 🧪 #morphogenesis #organoid #spatialtranscriptomics #singlecellsequencing

Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes - Nature Biomedical Engineering Arrayed CRISPR libraries with each plasmid encoding an array of four non-overlapping single-guide RNAs allow for the efficient genome-wide ablation, activation and epigenetic silencing of human protei...

Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes

www.nature.com/articles/s41...

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.

#WeekendRead! #ZombieNeutrophils! #InterferonsFriendsOrFoes?! Stallings &co show @ Cell Host & Microbe that micobacterium drives the releases of NET from live neutrophils (that lose their 🧠!) thanks to PAD4 & type I #interferons, favoring #Myb growth! www.cell.com/cell-host-mi...

We have very limited means of tracking inflammation in the body, like a one-off hs-CRP blood test.
Today @science.org
Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor
science.org/doi/10.1126/...

Holistic genetic barcoding reveals a lineage tree of tissue macrophage development Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...

#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...

The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage
www.cell.com/cell-host-mi... open-access