Here is the full programme (edrc2025alicante.com/program/), including times and room allocation. We look forward to seeing you in Alicante in two months' time! @fly-eds.bsky.social @drosospain.bsky.social

A gut sense for a microbial pattern regulates feeding - Nature A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

Nature research paper: A gut sense for a microbial pattern regulates feeding

go.nature.com/4oaiXPW

Metabolic adaptations of brain metastasis Nature Reviews Cancer, Published online: 24 July 2025; doi:10.1038/s41568-025-00848-1In this Review, Parida and Malladi summarize the metabolic adaptations of tumour cells upon dissemination to the brain, outline the metabolic crosstalk between cancer and brain-resident cells and discuss potential strategies to target these adaptations to improve outcomes for patients with brain metastasis.

NEW content online!

We are looking for 2 postdocs to join my lab at Sussex University in Brighton, UK (South of London, on the sea). One position is for a molecular/cell biologist, the other, for a neurobiologist/behavioural person. Drosophila experience desirable. Flyer w/more info below. Please repost. Thank you!

Pvf1-PvR-mediated crosstalk between the trachea and the gut guides intestinal stem cell migration to promote gut regeneration In adult tissues, stem cells (SCs) reside in specialized niches, where they are maintained in a quiescent state until activated by injury. Once activated, they migrate towards injured sites, where the...

Please read the very nice complementary study by the laboratory of our great colleagues @colombani-lab.bsky.social
www.biorxiv.org/content/10.1...

We found that enteroendocrine cells and enteric neurons talk to vascular like trachea to drive intestinal regeneration.
A true team effort lead by Andre Medina and Jessica Perochon. Thanks to all members of the lab who teamed up to take this paper to the finish line.

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

Very happy and proud to share the latest work from our lab.
Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...

Thank you for such important contribution!

Majority of fruit fly immunity studies can be replicated, huge analysis finds Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)

A new preprint from our lab.

Filopodia are essential for steroid release - PubMed Steroid hormones, crucial for development and physiology, were traditionally believed to diffuse passively through membranes. However, recent evidence shows insect steroid ecdysone being secreted via ...

Fantastic work by Nuria Romero and team! Check this out

Hello world! So lucky to host the one and only @lboulan.bsky.social tomorrow - come for the science, stay for the experience! @igred.fr

Israel kills at leat 60 in Gaza today, medics for survivors in Gaza City Israeli attacks continue, killing dozens, even as US claims a ceasefire is possible ‘within the next week’.

The daily war crimes from the genocidal regime continue without headlines aje.io/awhi55

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

A fantastic scientist and speaker.

The Cordero Lab has openings for two post-docs positions. Please contact me if you are interested in doing cross-species research on local and systemic intestinal biology.

Very nice piece bringing a lot of food for thought on how to rationalise our practices with fly pushing. It's been a long standing discussion on our side and I am gratefull someone did all the work estimating the impact of various practices.

Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.

training.institut-curie.org/courses/deve...

kollacin.siu.edu.ar/kollacin/apl...

Fabulous as usual!! Congrats Allison, Benjamin and the entire team!!!

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

Very happy to share our latest lab publication!
The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators!
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...

25 years of Drosophila “Sleep genes” The field of Drosophila sleep research, which began 25 years ago, has identified more than 200 genes influencing sleep. In this review, I summarize the foundation of the field and the growing list ...

New review article in Fly: Dr. Orie Shafer highlights how Drosophila has become a powerful model for dissecting the molecular and neural circuits of sleep, paving the way for future discoveries in both basic and clinical sleep science.

Super star congratulations!!!!

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Pleasantine Mill to the left, text to the right 100 extraordinary biologists Pleasantine Mill Pleasantine Mill is coordinating a JCS Special Issue, was recently interviewed on the Node as the 2025 BSDB Wolpert Medal winner and co-organised the 2024 DMM Journal Meeting. Pleasantine is a Group Leader at the MRC Human Genetics Unit, UK, investigating disease models and mechanisms of ciliopathies. #100biologists #biologists100

We are highlighting Pleasantine Mill, 2025 @bsdb.bsky.social Wolpert Medal winner, as an extraordinary biologist this week. Pleasantine is also coordinating a @jcellsci.bsky.social Special Issue and co-organised the 2024 @dmmjournal.bsky.social‬ Journal Meeting. #100biologists
@cilialab.bsky.social

European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!

#Drosophila @flybase.bsky.social requires emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!