CoSyne Therapeutics

Winner winner chili dinner! 🌶️ 🏆 It turns out that brain cells aren’t the only thing we’re good at seeding…

Congrats to the experimental bio team in Cambridge who have taken out the JCBC chilli growing contest for most chilis on a single plant!

Great to have everyone together for our company offsite yesterday! It’s always great to connect as a full team, celebrate our wins, and align on the next phase of our journey 🙌🧠🚀

#CoSyneTherapeutics #Glioblastoma #Bioinformatics #DrugDiscovery #BrainCancerResearch

We’ve got an incredible interdisciplinary team here at CoSyne Therapeutics! Mi is a senior computational biologist analysing our genomic data generated in the wet lab, and Sophie is our operations coordinator who supports the senior leadership team and wider company 🖥️🧬📋🧠

MYTH vs FACT: Think you know the truth about brain cancer? Let’s break down some common misconceptions! 🧠

Have you heard this myth before? 💭⁉️

#Glioblastoma #GBM #BrainCancer #BrainCancerResearch #BioTech

A huge congratulations to our bioinformatician Grant who conquered the great Steall Marathon in the Scottish Highlands on the weekend! He finished with an impressive time of 7:03 and placed 85 of 231 finishers. 🏃 🏔️ 🎖️

#CoSyneTherapeutics #Glioblastoma #BrainCancerResearch #Fundraising

🔔 Don't miss a thing! Our journey to fight rare neurological disease is happening on all our social media channels, and we'd love for you to join us.
➕ Follow us on all our pages to get the full story and support our mission.
#Glioblastoma #DrugDiscovery #BrainCancerResearch

If you are a UK citizen or resident, please lend your voice to this cause! [3/3]

Their mission is our mission: to accelerate progress in brain cancer treatment. They're calling on the UK government to increase research funding, standardise genomic sequencing for better-informed treatment, and enact "Right to Try" laws for those with terminal diagnoses. [2/3]

Petition: Invest in brain cancer and give rights – turn terminal into treatable Brain cancer is the biggest cancer killer of children and adults under 40, 87% with a high-grade brain tumour diagnosis die within 5 yrs, and yet it gets just 1% of the national spend on cancer.

We’re standing with Brain Cancer Justice, a new group founded by patients and advocates fighting for change. [1/3]

petition.parliament.uk/petitions/73...

#CoSyneTherapeutics #BrainCancerJustice #BrainCancer #Petition

#CoSyneTherapeutics #Glioblastoma #BrainCancerResearch #BioTech #KnowledgeGraphs

Instead of just relying on the data within the LLM compressed in its weights, the prompt contains now additional information from structured resources. Naturally, this can be also leveraged in agentic workflows that chain different tasks executed by the LLM together. [13/13]

🤖 Generative AI enhancement: Knowledge Graphs can provide structured data to large language models (LLM; for example ChatGPT) to reduce hallucinations and improve accuracy (known as retrieval augmented generation). [12/13]

📚 Biomedical literature: Which research groups are making similar discoveries? How strong is the evidence for a particular claim made in a research publication? Do we observe validation of findings/claims by other scientists? [11/13]

🔭 Beyond the drug repurposing use case:

Knowledge Graphs are transforming biomedical research (and other disciplines) in other ways too. Some examples: [10/13]

Instead of searching through scattered databases, we can ask complex questions like: "Show me all safety-approved drugs that target proteins we know are critical in GBM." The example below shows how this would work in practice. [9/13]

🔋 What makes Knowledge Graphs powerful?

Think of a Knowledge Graph as a network that connects related information, bridges different concepts, and shows the relationship between them. [8/13]

By mapping out these relationships, we can identify human-safe drugs that might be repurposed for treating GBM (and other deadly brain diseases). This could dramatically reduce the development time and risk typically required for the development of new treatments. [7/13]

- Which drugs have already passed safety trials?
- What proteins do they target?
- Which biological functions are these proteins involved in?
- How do those proteins and functions relate to brain cancer based on our proprietary biobank and experimental data? [6/13]

🖥️ℹ️ Our approach: Connecting the dots with our internal Knowledge Graph

We've built an internal Knowledge Graph, dubbed ‘CosyGraph’, that connects crucial pieces of the drug discovery puzzle. [5/13]

At CoSyne Therapeutics, we're using Knowledge Graphs to identify the most promising human-safe drugs to treat GBM (and other deadly brain diseases) and test them in our lab. [4/13]

Many of these drugs are already proven to be safe for use in humans. We believe the cure for brain cancer might already exist; we just need to find it. [3/13]

🧠💊 The challenge: Glioblastoma (GBM) is one of the deadliest brain cancers, yet thousands of potential treatments sit unused in portfolios of biotech and pharma companies. [2/13]

📝 Blog post of the week: How Knowledge Graphs are unlocking new insights for brain cancers and diseases [1/13]

🧠 Our own Computational Biologist Grant is fundraising for Brain Tumour Research by taking on the brutal Steall Mountain Marathon in September! 📷⛰️

Help him reach his fundraising goal by donating today!
www.justgiving.com/page/grant-n...

Brain Cancer Justice | Support Brain Cancer Awareness Join Brain Cancer Justice to advocate for increased funding, research, and support for brain cancer patients and families impacted by this deadly disease.

You can find out more about Brain Cancer Justice on their website (www.braincancerjustice.org) and Facebook/Instagram pages (@braincancerjustice)

Petition: Invest in brain cancer and give rights – turn terminal into treatable Brain cancer is the biggest cancer killer of children and adults under 40, 87% with a high-grade brain tumour diagnosis die within 5 yrs, and yet it gets just 1% of the national spend on cancer.

petition.parliament.uk/petitions/73...

Brain Cancer Justice currently have a petition to urge the UK government to increase funding for research and genomic sequencing, and enshrine Right To Try laws for terminally ill patients. If you are a UK citizen or resident, please consider signing their petition (link below)

He emphasised that patients often resort to spending thousands of pounds to travel outside the UK to try experimental treatments, as UK law does not currently have Right To Try protections for investigational drugs to be given to terminally ill patients.

Among the event speakers was the incredible Sam Suriakumar, who spoke to his experience of being offered the same limited treatment options for his glioblastoma that have been available for three decades.

This group aims to push for more transparent use of funding, leading to high-impact research, along with standardised genomic sequencing of brain tumours, so patients can be informed about personalised treatments for their specific tumour.