Brandon Yates, PhD

Intramuscular adipose tissue restricts functional muscle recovery Norris et al. demonstrate the detrimental role of intramuscular adipose tissue (IMAT) on muscle regeneration. Following injury, IMAT inhibition enhances muscle regeneration by increasing myofiber dens...

Intramuscular adipose tissue restricts functional muscle recovery
www.cell.com/cell-reports...

Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
insight.jci.org/articles/vie...

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine.bsky.social www.nature.com/articles/s41...

Serum C‐Terminal Agrin Fragment With Acute and Long‐Term Exercise and Angiotensin II Type I Receptor Blockade Background Sarcopenia represents a major clinical and societal challenge facing rapidly aging populations. Accessible and specific biomarkers represent valuable tools, both in diagnosis and assessin.....

🧪 Check out our new publication @ismcopenhagen.bsky.social highlighting important considerations for using CAF as a biomarker of muscle wasting, lead by 1st author Casper Soendenbroe 💪
⚠️Exercise timing and medication matter.

onlinelibrary.wiley.com/doi/10.1002/...

Blood biomarkers of Alzheimer’s disease and 12-year muscle strength trajectories in community-dwelling older adults: a cohort study Our findings suggest that blood Alzheimer’s disease-related biomarkers might help estimate progressive muscle strength decline among older adults, elucidating the influence of brain pathology and cogn...

www.thelancet.com/journals/lan...

Activity variability: A novel physical activity metric and its association with cognitive impairment INTRODUCTION Evidence suggests that engaging in a high volume of daily or weekly physical activity may reduce the risk of cognitive impairment due to Alzheimer's disease and related dementias (ADRD)...

Lower minute-level physical activity is associated with higher odds of cognitive impairment in older adults

A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch

alz-journals.onlinelibrary.wiley.com/doi/full/10....

Metabolite signatures of chronological age, aging, survival, and longevity Metabolism plays a crucial role in both aging and aging-related diseases, but the metabolites that serve as pivotal biomarkers of aging are not fully known. Sebastiani et al. analyze metabolites in pl...

Metabolite signatures of chronological age, aging, survival, and longevity: Cell Reports www.cell.com/cell-reports...

New @science.org
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

If you’re looking to boost your brain, start exercising! Studies show that 30-60 minutes of aerobic (cardio) exercise, 3-4 times per week, can lower your risk of developing Alzheimer’s disease and other dementias. Aerobic exercise increases your heart rate and enhances blood flow to the brain.

The metabolic drivers of IFN-γ release: glycolysis and acetyl CoA ride in the front seat Abstract. Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing im

The metabolic drivers of interferon-gamma release: glycolysis and acetyl CoA
academic.oup.com/jimmunol/adv...

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community - Nature Medicine In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community

Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia

www.nature.com/articles/s41...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...

Physical Activity, Alzheimer Plasma Biomarkers, and Cognition This cross-sectional study examines associations among physical activity, plasma biomarkers, and cognition in a multicenter cohort of patients with and without cognitive impairment.

Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition
jamanetwork.com/journals/jam...

Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease - Nature Communications Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.

www.nature.com/articles/s41...

Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT Our findings suggest that engaging in more moderate-to-vigorous physical activity might help to slow the age-related neurodegenerative process, although p-tau pathophysiology seems to mitigate the ben...

Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT - The Lancet Healthy Longevity www.thelancet.com/journals/lan...

Ever wondered why exercise is associated with reduced depression?

Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.

The dual role of feimin in metabolism and exercise - Nature Metabolism Back-to-back studies present evidence that feimin, a myokine, regulates glucose homeostasis and exercise performance. The secretory and intracellular roles of feimin provide insights into potential therapies for metabolic disease as well as for improving exercise performance.

NEWS&VIEWS | João V. Esteves & Kristin I. Stanford @osuwexmed.bsky.social

The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥

https://bit.ly/3CNZ6mE

Associations between objectively measured sleep characteristics and six-minute walk distance in older adults: the Disparities in Sleep and Cognitive Outcomes (DISCO) study AbstractStudy Objectives. A decline in physical functioning in older adults has been associated with a higher risk of chronic diseases. Subjective sleep di

Poorer objective sleep quality and irregular sleep were associated with poorer functional capacity in older adults. academic.oup.com/sleep/advanc...

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...

Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice This study investigated BDNF's role in skeletal muscle adaptations to aerobic exercise in mice. It examined acute and chronic exercise effects on BDNF response and compared chronic BDNF treatment to ...

Brain-derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
faseb.onlinelibrary.wiley.com/doi/10.1096/...

Enhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects Abstract figure legend Prehabilitative exercise is the process of preparing, through structured exercise, for anticipated disuse (e.g. bed rest or limb immobilization). Despite positive findings in c....

Enhancing muscle and brain resilience

physoc.onlinelibrary.wiley.com/doi/10.1113/...

The role of skeletal muscle respiratory capacity in exercise performance The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary resear…

“exercise regimes able to induce enough stress to trigger skeletal muscle mitochondrial adaptations, based on different combinations of intensity and volume, are of benefit for all populations: (young-old) irrespective of their level of fitness.

www.sciencedirect.com/science/arti...

I know of Kirby Mayer (Kentucky), Brad Gordon (Florida), Stu Phillips, and myself

Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults | Neurology Background and ObjectivesIndividuals aged 70 and older frequently experience an increased risk of deficits in both physical and cognitive functions. However, the natural progression and interrelations...

“This study highlights the variability in physical and cognitive performance among older adults and suggests that neuroimaging markers of neurodegeneration, cSVD, and microstructural WM integrity may account for these variations. “

www.neurology.org/doi/10.1212/...

Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade - Nature Communications Higher mitochondrial oxidative phosphorylation assessed in skeletal muscle through non-invasive MR spectroscopy predicts less brain atrophy and microstructural deterioration in community-dwelling adul...

Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade

www.nature.com/articles/s41...

Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals with dementia, aimed at health-care providers, particularly those in primary care. We conducted a rapid literature review followed by a consensus process involving 18 international experts on dementia and frailty. The experts identified key areas, including diagnosis of frailty, assessment of nutritional status and nutritional management, physical activity, prevention of falls, and polypharmacy management.

Assessment and management of frailty in individuals living with dementia

www.thelancet.com/journals/lan...

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling | American Journal of Physiology-Cell Physiology Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibres. Despite bei...

New work from our group: Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling #myoblue journals.physiology.org/doi/abs/10.1...

An expert consensus statement on biomarkers of ageing for use in intervention studies Abstract. Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which speci

An international consensus on biomarkers of ageing for use in human intervention studies.

academic.oup.com/biomedgeront...

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Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth.

#Glycotime

www.nature.com/articles/s41...