Stephanie Gomez

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

The only possible result to this will be massive layoffs across the US higher education system

This is... actually a fairly reasonable takeaway from this year.

I participated in a faculty panel a few weeks ago in which senior (ahem) faculty gave advice on careers in academia by pretending luck had very little to do with our success. One piece of advice riled me up, in which it was argued that a reason for their success was their ability to say no. 1/

Oh my

I've decided that when researchers say a treatment is "well tolerated" it actually means "I can tolerate my patients having toxicity" and nothing to do with what the patient thinks. We can only make such a statement if we use patient-reported outcome or experience measures.

Five latent factors underlie response to immunotherapy - Nature Genetics Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden,...

www.nature.com/articles/s41...

Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results - Nature Medicine Preliminary findings in seven patients with mismatch repair-proficient metastatic colorectal cancer who were treated in the context of a phase 2 trial show that adoptive transfer of autologous periphe...

ICYMI - over the summer Maria Parkhurst from our branch published one of the first reports of clinical responses after adoptive cell transfer of TCR engineered private neoantigen (tumor mutation) targeting T cells in metastatic cancer patients 🧪🦠🔬🩺 1/3 #Immunosky
www.nature.com/articles/s41...

A crowd of people wraps around a hallway. About 25-30 people are visible

UCSF hosted its first food pantry event for postdocs today, where a local food bank gives free food to UCSF employees.

This picture represents about half the line that had formed 10 minutes before the market had opened.

What the fuck are we doing here guys?

Two weeks without looking/listening to any news, so much this

Robert is right.

There’s a clip of RFK Jr saying his first week at the NIH he’s going to tell the various institute leads that “we’re going to give drug development and infectious disease a break, a little bit of a break, for 8 years.” I cannot overstate how disastrous this would be.

Very useful, indeed! Thank you so much!

Thank you so much!

Here's the #Cancer #Research #2 starter pack 🤩

Researchers, oncologists, patient advocates & more -working across all aspects of cancer research and treatment 🧪🔬⚕️

I also tried to give some exposure to #PhD #students & #postdocs - randomly picked from followers of me or my lab!

go.bsky.app/6EcjWNA

Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer Multimodal single-cell RNA sequencing identified a population of CD8+ T cells elevated in tumor tissue enriched for interferon-stimulated genes (ISG). These ISG cells are clonally related to a popula...

I am excited to share our latest paper. We profiled CD8+ TILs from HPV- HNSCC patients using scRNA/TCRseq. In addition, we performed an ex vivo stimulation of cells to capture their transcriptional response. 1/n

onlinelibrary.wiley.com/doi/10.1002/...