Ezra Aksoy

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This study challenges the concept that colon cancer is a strictly nontransmissible disease

Fabio Cominelli & team report on a missense mutation in Muc2 that promotes gut microbiome and metabolome-dependent colitis-associated tumorigenesis in mice: doi.org/10.1172/JCI1...

This is very impactful if we can further apply the findings in certain #monogenic #immunodeficiencies

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 The mTOR protein kinase forms two multiprotein complexes, mTORC1 and mTORC2, that function in distinct signaling pathways. mTORC1 is regulated by nutrients, and mTORC2 is a central node in phosphoinos...

www.science.org/doi/10.1126/...

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

The latest issue of #Science #Immunology is out now! This week:

• evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools

• de novo #thymus #regeneration in the #axolotl!

New content every week!!!

The January 2026 issue of #Science #Immunology is out now!

Thanks to Rioka Hayama for another fantastic cover!!!

Wishing you courage, luck and peaceful research.

The NIH has lost its scientific integrity. So we left “We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

www.statnews.com/2026/01/10/n...

nature on X: "Nature research paper: Human gut M cells resemble dendritic cells and present gluten antigen https://t.co/czItJZfbno" / X Nature research paper: Human gut M cells resemble dendritic cells and present gluten antigen https://t.co/czItJZfbno

Human gut M cells resemble dendritic cells and present gluten antigen

x.com/nature/statu...

UK to rejoin EU’s Erasmus student exchange programme Exclusive: British students will be able to participate in EU-wide scheme from January 2027, sources say

Breaking...

Very good news. A first step towards...?

www.theguardian.com/world/2025/d...

Viewpoint: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...

#Organelles #Development #Metabolism

We need to feed them

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

If i am not getting it wrong,would be a radically distruptive idea. But relying on q.e.d. for peer-review?

Would be good to test on long Covid patients

Fantastic study #gut is central to our #health

The gut-brain connection Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.

The gut-brain connection

Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.

Biochemical Journal on X: "Explore our themed collection, Cell Signaling in the 21st Century. This collection captures new developments in cell signaling through research, review articles and perspective pieces. https://t.co/t0TdfBn6Zy https://t.co/2mRyKJwnsM" / X Explore our themed collection, Cell Signaling in the 21st Century. This collection captures new developments in cell signaling through research, review articles and perspective pieces. https://t.co/t0TdfBn6Zy https://t.co/2mRyKJwnsM

Cell signalling milestones from #Biochemicaljournal.
Must 👇👇👇 x.com/biochem_jour...

Fundamental immunology 101: the basics of an immune response Tackling infections

I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky

Hamilton Oh on X: "I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗 https://t.co/2bxtfEJ0TS" / X I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗 https://t.co/2bxtfEJ0TS

Exciting times, a study shows organ specific #aging and future #disease can be measured. x.com/hammy_oh/sta...

Regulation of inflammatory responses by pH-dependent transcriptional condensates Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…

Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...

www.nature.com/articles/s41...

“Vaccines have saved 154 million lives globally since the launch of the Expanded Programme on Immunization by the World Health Organization in 1974 and are one of the great triumphs of medicine”

One more obstacle on the way CD4+ T cells unleashed 👇 Neuropilin 2

UK academic tracks Trump’s agenda ‘to discredit science’ - Research Professional News “This isn’t chaos—it’s a deliberate war on science and academic freedom,” says Christina Pagel

Very awed by the incredible work @chrischirp.bsky.social is doing and delighted to see this profile

Maladaptive #Trainedinnateimmunity in chronic inflammation and cancer 👇👇👇

The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!

We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!

www.nature.com/articles/s41...

This one is particle uptake via #phagocytosis which programs unique set of transcriptional response in #macrophages

Soluble antigen #crosspresentation by #macrophages in CD8 T cell priming 🫣