Rianne Prins

Can expression of a peptide lead to antimicrobial resistance? Yes it can!

We discovered this for a toxin we work with and started exploring how #peptides, #antimicrobialresistance and de-novo gene birth can come together.
@cp-trendsmicrobiol.bsky.social
Amazing work by @rianneprins.bsky.social

Small proteins and peptides conferring protection against antimicrobial compounds The secretion of antimicrobials is widespread among microorganisms, many of which have developed protection mechanisms. While well-characterized protection mechanisms involve relatively large proteins – such as exporters or compound- or target-modifying…

Small proteins and peptides conferring protection against antimicrobial compounds

Small proteins and peptides conferring protection against antimicrobial compounds The secretion of antimicrobials is widespread among microorganisms, many of which have developed protection mechanisms. While well-characterized protection mechanisms involve relatively large proteins...

Now online: can small proteins and peptides play a role in antimicrobial resistance?

With @billerbecks.bsky.social we explore this question here: www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social

For download: www.sciencedirect.com/science/arti...

Imperial Fungal Science Network | Seminar Series 2025 | Seminar A hybrid seminar program focussing on our key research themes: Biotechnology and Engineering; Ecology, Evolution and the Environment.

For yeast and fungi fans: I’ll be speaking about our work on the yeast toxicome on March 13th. Hybrid attendance possible.

www.imperial.ac.uk/events/18820...

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

The human genome encodes potentially thousands of tiny proteins that were previously overlooked.

The search is on to find out what they do

https://go.nature.com/41amXq2

Out now! We consolidated >600 Dutch yeast and characterised their activity against spoilage yeasts and relevant human and plant pathogens, focusing on yeasts that secrete antifungal proteins. Great resource for biocontrol and beyond.
pubmed.ncbi.nlm.nih.gov/39875071/

De novo designed proteins neutralize lethal snake venom toxins - Nature Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...

www.nature.com/articles/s41...

Structure-guided discovery of viral proteins that inhibit host immunity Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...

New preprint from the group of @billerbecks.bsky.social!