Martin Thanbichler

Also see recent complementary work from the Priyadarshini lab on this topic: journals.asm.org/doi/10.1128/...

Peptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus Most bacteria possess a peptidoglycan sacculus, which is continuously remodeled during cell growth and division. The peptidoglycan (PG) fragments generated in this process are typically imported into ...

We are happy to share our latest preprint:
www.biorxiv.org/content/10.1...

A great collaboration with Waldemar Vollmer’s group, along with our fantastic proteomics and metabolomics facilities.

@synmikro.bsky.social

Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...

new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation - Nature Communications ParABS systems partition chromosomal DNA and low-copy plasmids in bacteria. Here, the authors elucidate the mode of interaction between ParA and ParB and clarify how ParB stimulates the ATPase activity of ParA to drive the segregation process.

www.nature.com/articles/s41...

#microsky

We investigate the
▪️function and conservation of the bactofilin MTS
▪️cooperativity of membrane binding and polymerization
▪️role of client proteins in bactofilin assembly

Thanks to the Schäfer and Bange labs as well as our HDX and EM facilities for the fruitful collaboration!

Now published as a Version of Record, with various new results compared to the initial preprint:

Membrane binding properties of the cytoskeletal protein bactofilin

Available at:
elifesciences.org/articles/100...

@synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social

Engineering Spatial Control of Bacterial Organelles Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

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Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

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Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

We're hiring a DFG-funded PhD student (TVöD E13, 65%) at Max Planck Institute, Marburg to study quorum sensing in Klebsiella & host–pathogen interplay. 3 yrs, start flexible. Apply by Sep 30, 2025 (rolling). Send 1 PDF to laganenka@mpi-marburg.mpg.de

Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...

One of the most exciting discoveries from our lab so far is now online as a preprint!

Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...

🚀Women in STEM: Are you a late-stage PhD student or postdoc in the life sciences?
The September Science Academy in Marburg offers talks, lab tours, workshops – and the chance to present your own research! Apply now 👉 www.mpi-marburg.mpg.de/1489492/Sept...
#LifeSciences #AcademicCareers

Congratulations to Rebecca Hinrichs on her first senior-author paper! @synmikro.bsky.social @unimarburg.bsky.social

academic.oup.com/nar/article/...

How does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species". Happy to see this paper in print @natcomms.nature.com. Nice work by @mariedelaby.bsky.social, Liu Yang et al. See original 🧵, different colours, same data and conclusions.

Bactofilins are essential spatial organizers of peptidoglycan insertion in the Lyme disease spirochete Borrelia burgdorferi The Lyme disease spirochete Borrelia burgdorferi has a distinctive pattern of growth. Newly-born cells elongate by primarily inserting peptidoglycan at mid-cell, while in longer cells, additional inse...

A new study from the Takacs lab, showing that bactofilins are essential for viability and critical for cell shape in the Lyme disease spirochete Borrelia burgdorferi:

www.biorxiv.org/content/10.1...

*** Only a few days left to apply ***

Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"

Spatiotemporal regulation of cellular processes by CTP-switches in bacteria

Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

Learning the dynamic organization of a replicating bacterial chromosome from time-course Hi-C data https://www.biorxiv.org/content/10.1101/2025.04.03.647011v1

#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"

Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)

Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

New postdoc position available at IBVF!

Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation DNA segregation by bacterial ParABS systems is mediated by transient tethering interactions between nucleoid-bound dimers of the ATPase ParA and centromere (parS)-associated complexes of the clamp-for...

Interested in the bacterial ParABS DNA segregation system? Then have a look at our latest preprint... 🧬

Thanks to the Hennig and Bange groups for the great collaboration!

doi.org/10.1101/2025...

Pictures of Lise Meitner Group leaders: Sofie Valk, Flore Kunst, Anna-Maria Meister, Maria Sokolova, Heidi Colleran, Nathalie Feiner und Ulrike Kraft.

Want to lead a research group at a Max Planck Institute – with a #tenuretrack position & substantial resources?

Apply for the Lise Meitner Excellence Program by @maxplanck.de. The program aims to promote exceptionally qualified #WomeninScience. Deadline: April 8, 2025
www.mpg.de/lise-meitner...

Congratulations, Geraldine!