Francesca Telese

HuD controls widespread RNA stability to drive neuronal activity-dependent responses Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

How does cannabis use during adolescence impact brain development?

Using single-nuclei transcriptomics in mice, we found that cannabis and a genetic risk factor (Reln) interact to disrupt gene expression programs underlying neuronal migration of neuroblasts in the nucleus accumbens.

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species Neuroscience; Cellular neuroscience; Transcriptomics

Our paper providing transcriptomic profiles of lateral septum (LS) cell types in human 🧠 is now online: www.cell.com/iscience/ful...

All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

Neuroscientists need to do better at explaining basic mental health research The knowledge gap between scientists, health-care professionals, policymakers and people with mental health conditions is growing, slowing the translation of basic science to new treatments.

A challenge for basic scientists is to guarantee that the future generation of health-care professionals and policymakers understands the importance of addiction and mental health research.

By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social

bit.ly/42oULRu

#neuroskyence

It is Faculty interview season, so I created a doc with compiled Chalk Talk advice! Please share widely- this shouldn't be hidden curriculum... there is a recipe for success! I will also share videos of my practice and actual UCSD chalk talk with anyone who wants it! DM me!

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*

*should be specific to gene regulation

🏴‍☠️I’m ready🏴‍☠️

Why don’t new memories overwrite old ones? Sleep science holds clues Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.

How does the brain avoid overwriting old memories when new ones are created? New data (in mice) provides a hint: old & new memories are processed during different stages of sleep www.nature.com/articles/d41...

California Fire Relief In response to fire across California, Direct Relief provides N-95 masks, medicine, and other resources to public agencies and first responders in wildfire-affected communities.

If people want to help and are able to donate to help those affected by these LA fires, here are places they can donate:

friendsindeedpas.org/donate-to-fr...

cpf.salsalabs.org/disasterreli...

www.directrelief.org/emergency/ca...

www.pledge.to/ccfwildfirer...

www.globalgiving.org/projects/cal...

I’m speechless looking at the devastation caused by these fires :(

Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells Mammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long nonco…

Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells

www.sciencedirect.com/science/arti...

This is fascinating! Congrats @brunetlab.bsky.social & colleagues! Cool findings on vascular/pericyte & meningeal/perivascular fibroblast cell types - important to exercise to keep those 🧠 blood vessels young and functional 🏃‍♀️🏋️‍♂️...but also what are the fibroblasts up to?!? 👀 🧪 #BBB #fibroblast

Nucleosome fibre topology guides transcription factor binding to enhancers - Nature Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

TF motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers

www.nature.com/articles/s41...

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1

Can I be added please?

Good bye #ACNP2024. Thanks for the great science and the best karaoke night!

Travel Award Stipends - Students, Postdocs, Junior faculty. GBB25 19-22 May, 2025, Yanuca Island, Fiji
Deadline: 17th January 2025.
More here: www.ibangs.org/travel-award... @twbredy.bsky.social

Huge congratulations 🎉

Males and females show different patterns of risk for brain-based conditions. Ignoring these differences does us all a disservice. Although studying sex differences in the brain is complex, technically awkward and socioculturally loaded, it is absolutely essential.

Although studying sex differences in the brain is complex, it is essential. Armin Raznahan @bogglerapture.bsky.social explains why ignoring different patterns of risk for brain-based conditions among males and females does us all a disservice.

www.thetransmitter.org/sex-differen...

Don't miss the Women and Gender-Minority Luncheon Symposium, "Respond Rapidly and Professionally to Macro- and Micro- Aggressions", sponsored by the Gender Equity and Inclusion Committee. #ACNP2024

📅 Today, December 10th
🕒 11:00am - 1:00pm MST
📍 Grand Saguaro

Degron-modified Cas12a enhances single-cell CRISPR screening Single-cell CRISPR (Perturb-seq) screens have primarily relied on Cas9 whereas Cas12a, despite its unique effectiveness for multiplex guide expression, remains underexplored. This may be due to Cas12a...

Have you been interested combining Perturb-Seq screening with Cas12a’s unique capabilities for multiplexed guide RNA expression? Us too! So, we figured out some useful tricks to make that possible, which you can find in our new pre-print. Short thread below: www.biorxiv.org/content/10.1...

Desert views at #ACNP2024 Excited to meet the ACNP community. Stop by my poster M116 on Monday afternoon.

Prune cake with Almsrgnacg

Baking a prune cake for my kids before heading off to a conference! #ACNP #AcademicMom

Excited for my 3rd #ACNP. My lab at #UCSD works on gene regulation in substance use disorders. Stop by my poster on Monday afternoon to check out our latest single cell genomics findings in outbred rats #genetics #genomics #singlecell #opioids

Celebrating the recent achievements of our lab members. Grateful for this talented, hardworking, and inspiring team.
#Teamwork #LabLife

Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1 Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discov

Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1

Pecan pie

Pecan pie is ready. Happy Thanksgiving new 🦋 friends #thankgiving2024

A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable Coming less than a decade after its launch, the studies emerging from the global project are a major achievement. Funders should sign up for the long haul.

A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable

#HCA
@natureportfolio.bsky.social

www.nature.com/articles/d41...

LOL...still figuring out how this thing works 🦋