ConcepcIonLab@UChicago

Congratulations, Ada!

The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s

Thank you to @jphysiol.bsky.social for highlighting our review on volume-regulated anion channels #VRACs in #Immunity and featuring it in the August 2025 Editor’s Choice issue. 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 Online now - the Feature Review "LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation" from Thomas Jentsch et al.

#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling

Read it here: authors.elsevier.com/sd/article/S...

🎉 NEW ISSUE LIVE🎉

This special issue, guest-edited by Jorge E. Contreras of ucd-physiology.bsky.social, explores 'Current advances in Large‐pore channels: from structure‐function to physiology and disease' 🔍

📖 Access it here: physoc.onlinelibrary.wiley.com/toc/14697793...

Research by Yulia Kostritskaia et al. observes that Sphingosine-1-phosphate activates LRRC8 volume-regulated #anion channels through Gβγ signalling 🔬 📶

Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jorge E. Contreras of ucd-physiology.bsky.social introduces the special issue 'Current advances in large-pore channels: From structure–function to physiology and disease' in this #Editorial ✍️

🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Friday, 15 August, is the last day to submit your abstract to be considering for a short talk and/or travel award for SGP 2025!http://sgp2025.com Join us to hear talks by Henry Colecraft, Sheel Dodani, Rod MacKinnon, and many other great speakers!

Red moon last night, from
Chicago 😉

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

Current advances in large‐pore channels: From structure–function to physiology and disease Click on the article title to read more.

Large-pore channels: the Transformers of membrane proteins, versatile, dramatic, and never just selective or passive conduits.

Not just simple (typical) ion channels, they’re molecular multitaskers we’re beginning to comprehend.

Don’t miss the first-ever special issue dedicated to this!

📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!

Many warned me about the risks of speaking up publicly for science. I’m here to say I’ve faced no retaliation. On the contrary, I’ve received support, appreciation, and even some positive outcomes. Do what you can to save 🧪

Join us for the 11th Intnl #GDTcells conf in Toronto (May 20-23) as we celebrate emerging research and inspire future directions. I will be wearing two hats: conf organizer and repping #GDTcellclub w/ @eberlmat.bsky.social. Pls come say hi! @forum-gd.bsky.social
na.eventscloud.com/website/7048...

The structure of human sweetness A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods. Single-particle cryo-EM reveals the structure of the human sweet taste receptor, a heteromer composed of TAS1R2 + TAS1R3 GPCRs.

Now online! The structure of human sweetness

YouTube video by Steve Lawson Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Guest Editors are Anne Carlson & Zhaozhu Qiu 👉 rupress.org/JGP/pages/ca...

SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.

chemsymposia.com

#CallForPapers! Topics of interest include, but are not limited to, chloride channel and transporter structures and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...

Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.

www.nature.com/articles/s41...
www.nature.com/articles/d41...

Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com

Rewilding catalyzes maturation of the humoral immune system Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

Now in #Science #Immunology: @ejohnwherry.bsky.social & al use Tox-inducible KO mice to show that continuous #TOX expression in established exhausted #CD8 #Tcells (Tex cells) acts as enduring epigenetic control to reinforce Tex cell fate. Findings suggest TOX might be useful therapeutic target!

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

It’s wild that US NIH study sections—literally the backbone of biomedical research funding and future medicines—didn’t miss a single session during the pandemic. Not one. And yet, here we are…

National Institute of General Medical Sciences NIGMS supports basic research to understand biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention.

The NIH diversity supplement pages have all been pulled down. What is a diversity supplement and why should the public care? A diversity supplement is funding to help diversify the research workforce. You may be wondering, “so what?”. Let me explain. www.nigms.nih.gov/Pages/PageNo...

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

Do not miss this seminar tomorrow! 📌