Trends in Biochemical Sciences

📝 Online now - the Feature Review "Transactions on micronuclear DNA and implications for immune signaling" from @johnmaciejowski.bsky.social and Roger Greenberg.

#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse

Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...

Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.

#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics

Read it here: authors.elsevier.com/sd/article/S...

🚨Reminder - the #TIBSCelebrates50 call for cartoons is open!

50 years ago, we featured cartoons alongside and within our review content - we are reviving this staple with a new article format called #ScienceSketch!

💡 Share your ideas with us: www.cell.com/trends/bioch...

#TIBS50 #SciArt

Autophagy regulation by phase separation, avidity, and wetting Autophagy enables cells to selectively degrade a wide range of macromolecules, and how this process achieves spatial precision within the densely packed cytosol is an active area of investigation. Rec...

Physical principles have redefined our understanding of autophagy.

In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.

Great collaboration with @wilflinglab.bsky.social

www.cell.com/trends/bioch...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

Primary @cp-cell.bsky.social article: "Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures" from Guang-Hui Liu and colleagues.

Read it here: www.sciencedirect.com/science/arti...

📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang.

#Proteostasis #Aging #BiologicalClocks #Proteomics

Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...

📝 Online now - the Review "Proteases in bacteriophage defense systems and their potential in bioengineering" from Stan Brouns and colleagues.

#PhageDefense #ProteaseAssociatedDefenseSystems #PADS #ProteinEngineering

Read it here: authors.elsevier.com/sd/article/S...

💡 A Spotlight from Wagner Araujo et al describing recent research on mitoproteomics
📝 A Forum on the cGAS-STING pathway and lysosome from Wei Wan et al
🔬 A Technology of the Month on characterizing #glycoRNAs from Yuan Ma et al

(5/5)

Want even more? Then check out:
🥼 A Scientific Life from @jestsai.bsky.social et al on implementing a daily standup meeting for #accountability and #psycholocialsafety
💡 A Spotlight from @goemanslab.bsky.social highlighting work on defluorination activity in gut microbiota

(4/n)

Don't miss out on other great Reviews!
📝 The role membranes play in #Huntington's disease is Reviewed by Justin Legleiter
📝 Sebastian Glatt et al Review how #RNAmodifications in ribosomes can be mapped to high resolution

(3/n)

Don't miss out on other great Reviews!
📝 A Review from Shaun Olsen et al on #E3Ligases in signaling and therapeutics
📝 A Review from Joseph Cotruvo et al characterizing #Lanthanide biochemistry
📝 Ana Garcia-Saez et al Review the central role mitochondrial membranes play in cell death pathways
(2/n)

📢 Our November issue is now online! Access the full issue 👉 www.cell.com/trends/bioch....

🎨 The cover highlights a Review from Octávio Franco and colleagues describing self-assembling #antimicrobialpeptides.

(1/n)

📝 Online now - the Review "Emerging functions for nonhistone protein acetylation in budding yeast" from Michael Downey and colleagues.

#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation

Read it here: authors.elsevier.com/a/1m4nM3S6Gf...

📝 Online now - the Review "Molecular mechanisms of the mammalian fatty acid cycle" from Christian Gusenda and @m-grininger.bsky.social.

#FattyAcidBiosynthesis #FattyAcidSynthase #FAS #mFAS #AcylCarrierProtein #ACP

Read it here 👉 authors.elsevier.com/sd/article/S...

🎉 To commemorate #TIBS50, we need help from our community! Share your biochemistry-inspired cartoons and see them published in our NEW article format - #ScienceSketch!

📅 Get your cartoons in and get published with TIBS!

ℹ️ More information at: lnkd.in/edXQmmeg

#TIBSCelebrates50 #SciArt

✏️ Do you have biochemistry-inspired cartoons you'd like to see published? Then share them with us!

🎉 For #TIBSCelebrates50, we're bringing back the cartoons found in our early issues!

ℹ️ More information at: www.cell.com/trends/bioch...

#TIBS50 #SciArt #ScienceSketch

#Announcement🎤

🎉We are delighted to announce the 5th FEBS-IUBMB-ENABLE Conference focusing on integrative and cross-disciplinary research in the field of Life Sciences.

📍 Kraków, Poland | 🗓️ 14–16 Oct, 2026
Hosted by Jagiellonian University

For more info : febs-iubmb-enableconference.org

Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal deg...

(2/2) @natchembio.nature.com - "Highly specific intracellular ubiquitination of a small molecule" from Jonathan Ostrem and colleagues: www.nature.com/articles/s41...

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 - Nature Communications Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule substrates, beyond proteins. This di...

Primary articles being highlighted:
(1/2) @natcomms.nature.com - "Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1" from Sonja Lorenz and colleagues: www.nature.com/articles/s41...

💡Online now - the Spotlight "Drug ubiquitination: an unwelcome mode of action or a novel modality" from Richard de Heiden and Monique Mulder.

#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors

Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...

Available online - the Review "A tale of two dimers: #lanthanide recognition at biomolecular interfaces" from Wyatt Larrinaga and Joseph Cotruvo Jr.

#MetalIonHomeostasis #RareEarthMetals #Lanthanome

Read it here: authors.elsevier.com/a/1l%7E4u3S6...

🎉 To commemorate #TIBS50, WE NEED YOUR HELP! Share your biochemistry-inspired cartoons and see them published in a NEW article format - #ScienceSketch!

📅 Get your cartoons in NOW and get published with TIBS!

ℹ️ More information at: lnkd.in/edXQmmeg

#TIBSCelebrates50 #SciArt

📢 We're delighted to welcome six new members to our Advisory Board! The diverse expertise and fresh insights these researchers have will beautifully complement and expand upon the incredible knowledge already impacting the journal.

📢 2 weeks left to share your #coverart and help us celebrate #TIBS50!

If chosen, have that work featured on the January 2026 issue of TIBS!

ℹ️ More information at: www.cell.com/trends/bioch...

#TIBSCelebrates50 #SciArt

Want to see your artwork featured on the cover of a scientific journal?! Share your ideas at @cp-trendsbiochem.bsky.social!

🎉 Help us celebrate #TIBS50 and share your #CoverArt now! 📅 Deadline is October 31!

More information at: lnkd.in/e6db3_nr

#TIBSCelebrates50 #SciArt

Do you have biochemistry-inspired cartoons you'd like to publish? Share them with us!

🎉To celebrate #TIBS50, we're bringing back the cartoons found in our early issues!

📅 Get your #ScienceSketch in now and get published!

ℹ️ More information at: www.cell.com/trends/bioch...

#TIBSCelebrates50

📢 The deadline to share your #coverart and help us celebrate #TIBS50 has been extended!

Share your unique artwork and, if chosen, have that work featured on the January 2026 issue of TIBS!

ℹ️ More information at: www.cell.com/trends/bioch...

#TIBSCelebrates50 #SciArt

🔊 An all-science review journal joins us @cellpress.bsky.social, and is now accepting proposals!

Share your ideas with us!

#TIBSCelebrates50 #TIBS50 #ScienceSketch #SciArt

More information at: www.cell.com/trends/bioch...

Online now - the Review "Zn2+ transients and signaling in mammalian systems" from Ananya Rakshit and Amy Palmer.

#Zinc #ZincTransients #ZincSignaling #FluorescentProbes #LiveCellImaging

Read it here: authors.elsevier.com/a/1ltlt3S6Gf...