Lennart Hilbert's Avatar

Lennart Hilbert

@lennarthilbert.bsky.social

Studying the cell nucleus in search of inspiration for future DNA computers. Systems Biology professor at Karlsruhe Institute of Technology, post opinions mine alone. hilbertlab.org

2,481 Followers  |  1,055 Following  |  550 Posts  |  Joined: 10.10.2023
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Posts by Lennart Hilbert (@lennarthilbert.bsky.social)

Postdoctoral Researcher (ERC-funded project)

Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if youโ€™re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal ๐Ÿชผ ๐Ÿชฑ ๐Ÿž ๐ŸฆŽ ๐Ÿฆ‹ ๐Ÿ•ท๏ธ tree of life www.biozentrum.unibas.ch/open-positio...

02.03.2026 12:11 โ€” ๐Ÿ‘ 16    ๐Ÿ” 22    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Passionate about transcription?

๐Ÿš€ Weโ€™re recruiting a PhD student in Transcriptional Regulation at @ucph.bsky.social Start Summer 2026

Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab @cgen2025.bsky.social

Meet us: gregersenlab.com

Apply by Apr 10, 2026๐Ÿ‘‡
tinyurl.com/PhD-CGEN

02.03.2026 11:54 โ€” ๐Ÿ‘ 4    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Over on threads someone just use ai;dr and we all need to adopt that right quick

11.02.2026 19:56 โ€” ๐Ÿ‘ 11991    ๐Ÿ” 4159    ๐Ÿ’ฌ 86    ๐Ÿ“Œ 190
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Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...

14.02.2026 10:00 โ€” ๐Ÿ‘ 60    ๐Ÿ” 29    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 5

๐Ÿ‘ Thanks for the thread overview, exciting stuff!

14.02.2026 15:29 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Woah ๐Ÿ˜ณ

14.02.2026 15:28 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
HEALTH + LIFE SCIENCE ALLIANCE | Interinstitutional Postdocs

Exciting Postdoc Opportunities โ€“ Alliance Interinstitutional Program
**Deadline:** March 31, 2026 (5:00 pm CEST)
๐Ÿ”— Two shared positions: www.syn-gen.de/alliance-pos...
๐Ÿ”— Full call & application info:: www.health-life-sciences.de/opportunitie...

09.02.2026 05:34 โ€” ๐Ÿ‘ 3    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿ“ขJob alert๐Ÿ“ข

@uniheidelberg.bsky.social has an opening for a full W3-position on โ€œModeling of Biological Processesโ€ ๐Ÿ˜€๐Ÿ‘ Here is the call

tinyurl.com/3w9e9dtf

and application deadline is March 15. The group would be located at the beautiful #BioQuant center right in the middle of Neuenheimer Feld.

30.01.2026 15:47 โ€” ๐Ÿ‘ 32    ๐Ÿ” 28    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Monday: new Postdoc arrives at the lab

Friday: first own experiment, DNA nanostar condensates clearly visible, even in in vitro transcription buffer

Welcome on board, Dr. Marcel Piepers! Stay tuned!

PS Marcel is co-supervised w Ralf Reussner, tasked w ground work for www.sfb1608.kit.edu @kit.edu

06.02.2026 17:09 โ€” ๐Ÿ‘ 11    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

30 million is like 1 building at KIT. When I drive in, I pass 3 construction sites aloneโ€ฆso, yes, not perfect here, either, but currently, thereโ€™s money

06.02.2026 13:08 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

And it says "October 2025" on the cover, while it is published online January 2026. Not sure what it all means, but happy nevertheless!

29.01.2026 10:26 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Aaron Gadzekpo prepared the simulations for this design. He gave me printouts, which I then used to make a sketch with markers on an overlaid paper. I tried like 5 different scanners to get a decent image, finally used our institute multi-purpose printer. Hope you like the final appearance :-)

29.01.2026 10:25 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Apparently, we made the (additional) cover of the January issue of Annals of the NY Academy of Sciences with our artistic representation of surface condensates on a chromatin strand. I hope you appreciate the subtle use of a modified Hilbert curve?

nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...

29.01.2026 10:25 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Super feature zu Regenerationsforschung

Bei SWR Kultur gehรถrt: Kรถrperteile nachwachsen lassen โ€“ Was die Medizin von Tieren lernt - Forschung www.swr2.app/s/koerpertei...

28.01.2026 08:16 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Full Professor and Chair Laboratory of Biophysics We are looking for a Full Professor in the Biophysics chair group, part of Wageningen University & Research (WUR)

www.wur.nl/en/vacancy/f...

Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!

28.01.2026 05:20 โ€” ๐Ÿ‘ 23    ๐Ÿ” 48    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

23.01.2026 18:35 โ€” ๐Ÿ‘ 17    ๐Ÿ” 19    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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All key information about the German Fish Meeting at COS, Heidelberg (16โ€“18 September 2026) is summarized in this flyer. Please feel free to share it with colleagues and researchers working with any fish model. Thank you!

24.01.2026 09:36 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Progressing well with this yearโ€™s Master course Methods of Developmental Genetics, got the first immunostained zebrafish animal caps on the microscope today, nuclear pores looking great, participants in good spirits โœŒ๏ธ

Greetings to all fish labs ๐ŸŽ

22.01.2026 19:29 โ€” ๐Ÿ‘ 7    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Journals explaining why it takes 9 months to send back reviews

21.01.2026 18:08 โ€” ๐Ÿ‘ 53    ๐Ÿ” 3    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1

Just make sure itโ€™s a big publisher with transfer option?

21.01.2026 21:55 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

*of

20.01.2026 13:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Click bait from yesterdayโ€™s safety introduction for 2026 Masters course โ€œMethods if Developmental Geneticsโ€

Here my text to go along

This is your hand
This is your leg
This is your foot

Just let it fall
To the floor

First three: one drop into the kiwi
Last one: tweezers upright in the floor

20.01.2026 13:12 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Nailed it

17.01.2026 12:43 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Co-transcriptional RNA processing boosts zygotic gene activation Transcription decodes protein-coding genes and interprets regulatory information embedded in the genome by generating RNA. In eukaryotes, gene transcription is coupled with RNA processing via the carboxyl terminal domain (CTD) of RNA polymerase (Pol) II, which enhances messenger RNA (mRNA) production. We propose that co-transcriptional RNA processing is essential for zygotic gene activation (ZGA), transitioning the transcription program from noncoding to protein-coding after fertilization. Truncating the CTD in mouse cells disrupts this coupling, halting global mRNA synthesis and increasing noncoding RNA (ncRNA) levels through enhanced intergenic transcription and RNA stabilization. CTD truncation also triggers epigenetic reprogramming and nuclear reorganization towards totipotency, resembling early cleavage embryos. Mechanistically, the CTD restrains nonproductive polymerase activity in noncoding sequences, while at protein-coding genes requiring RNA processing, it promotes elongation by facilitating polymerase promoter-proximal pausing, transcription directionality, and velocity. Longer CTD lengths enhance gene activity, likely evolving to accommodate the increasing noncoding sequences in mammalian genomes. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org/content/10.1...

16.01.2026 20:39 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thank you ๐Ÿ˜Š Let me know if you have any questions or thoughts on it

16.01.2026 17:39 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

They actually put the handles :-)

16.01.2026 12:43 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

A. Ma. Zing.

I didnโ€™t spot this at all! Glad I bothered to put them in at proof stage

16.01.2026 12:42 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Oh, we don't have the handles, right_ I supplied them during proofing, but not sure they made it in...

16.01.2026 09:32 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Current Opinion in Genetics & Development | Genome Architecture and Expression (2026) | ScienceDirect.com by Elsevier This collection summarizes key aspects of our current experimental and theoretical understanding of eukaryotic genome folding and its relationship with the molecular processes governing cell fate. Ove...

There is a special Current Opinion in Genetics & Development issue about genome architecture and expression and it looks great including reviews by @lennarthilbert.bsky.social @yghavi.bsky.social and @wbickmor.bsky.social

www.sciencedirect.com/special-issu...

16.01.2026 08:40 โ€” ๐Ÿ‘ 19    ๐Ÿ” 8    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Thank you, too :-)

These answers are precise, and leave my internal image of the underlying process intact, phew ๐Ÿ˜ฎโ€๐Ÿ’จ

Only minor surprise (maybe you have a good reason), why alpha-amanitin and not actonomycin D? Itโ€™s more selective in its โ€œjammingโ€ effect, minus degradation effects of a-amanitin.

15.01.2026 21:30 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0