Xi Chen

🚨If you are in Toronto for #AAIC25, come to room701 at 2pm today (Tuesday)! I’ll present in the developing topic session on tau biomarkers!🩸->🧠

Apply for the opportunity to serve on JNeurosci’s Early Career Researcher Advisory Board to get more involved in scientific publishing and advocate as an early career researcher.
Learn more and submit your application by July 25, 2025, 5pm ET: https://www.jneurosci.org/content/ecr-board-applications

Hi Early Career Researchers (ECR) in neuroscience!🧠 I've had a great time working as an ECR advisory board member in the Journal of Neuroscience @sfnjournals.bsky.social and learned so much from my peers and journal editors! We now invite you to join us! @sfn.org www.jneurosci.org/content/ecr-...

With the first blood test for AD approved for clinical use, there may be great use of it to infer regional pathology when PET is not an option. Hasom Moon (the first author of the paper) is now studying the discordant cases to better understand and maximize the use of blood-based biomarkers!

With these relationships, we can use p-tau217 to estimate the staging/severity of tau in the brain🧠. The comparison between p-tau217-estimated tau map and actual tau PET shows high similarities(!) for both cross-sectional estimation (top) and longitudinal prediction (bottom)!

First paper from CHEN lab!🩸->🧠Can we use p-tau217 value to estimate PET-like map of AD pathology?🤔 We say YES!💡In two datasets (A4, ADNI), p-tau217 level can predict concurrent Ab (but NOT Ab change) and future tau accumulation almost everywhere!
www.sciencedirect.com/science/arti...

Human lifespan changes in the brain’s functional connectome - Nature Neuroscience Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...

Here is a cool study showing functional connectivity changes across the lifespan using 33250 people’s data from 132 global sites!
www.nature.com/articles/s41...

a man with glasses and suspenders is standing in front of a group of people and says science !! ALT: a man with glasses and suspenders is standing in front of a group of people and says science !!

Come to sunny Puerto Rico ☀️ #HAI2025 and see our poster on the predictive value of plasma pTau217 on tau PET at the regional level! Please check out Poster No.80 on Thursday 16th! 🧠 🩸

Working in this paper was a really fun collaboration with folks at AMYPAD, Lyduine Collij, Ariane Bollack, Gill Farrar and many others.
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Evaluating Models of the Ageing BOLD Response Linear and nonlinear methods for estimating the BOLD response in the sensorimotor task from a large dataset show important effects of adult age on response features and biophysical parameters, some o....

Our paper finally appeared on modelling the effect of age on the BOLD fMRI response, one implication of which is that many age effects previously reported may be vascular rather than neural… onlinelibrary.wiley.com/doi/full/10....

I’d love to be added if possible! Thank you!

I’d love to be added if possible. Thank you!

I’d love to be added if possible! Thank you!

I’d love to be added if possible! Thank you!

I’d love to be added if possible! Thanks!

I’d love to be added! Thank you for creating it!

🤩 would love to be added!

Many thanks to my coauthors who are not on Bluesky!🙏 We are excited about these interesting results! It gives us more hope🤩 in localizing early pathology and neural deficits driving differential cog declines, which is part of my current research! (I'm recruiting PhD students🧑‍🎓 if you are interested!)

We think these specific pathology-cog relationships may be due to the regions' functional roles and the particular vulnerabilities of the frontal-parietal (executive) network to Aβ and temporal (memory) network to tau in the very early stage of AD development!

Then relating the domain-specific residuals to PET change, we found Aβ increases in right frontoparietal tracked EF decline, but not memory, even after controlling for tau change; tau increases in left MTL tracked memory decline, but not EF, after controlling for Aβ change -- a double dissociation?!

Using longitudinal data in 76 older adults from the Berkeley Aging Cohort Study (~3 yrs PET, ~5 yrs cog), we first calculated domain-specific cog change residuals that represent how much faster their EF declined than expected based on their rate of memory decline (and vice versa)

Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults The early accumulation of AD pathology such as Aβ and tau in cognitively normal older people is predictive of cognitive decline, but it has been diffi…

🚨 Please check out our new paper on a double (triple?) dissociation between early AD pathology and cognition: frontal-parietal Aβ increases related to executive function (EF) decline, but not memory; temporal tau increases related to memory decline, but not EF! www.sciencedirect.com/science/arti...

The application deadline is Jan 15! Our PhD students are fully funded; if you are a US domestic student, we encourage you to apply before Dec 15 for consideration for additional fellowship!
#neuroskyence #psychscisky #psychjobs #academicsky #BlackInNeuro #Neuroimaging #cogpsyc #Psychology #PhDSky

Integrative Neuroscience | Department of Psychology SUNY Stony Brook Psychology Integrative Neuroscience Overview

‼️I am recruiting integrative neuroscience PhD students (fully funded) for this coming cycle Fall 2025 at SUNY-Stony Brook University.🧑‍🎓Email me if you are interested in cognitive aging, Alzheimer’s disease, and neuroimaging! 🧠 RT is appreciated! www.stonybrook.edu/commcms/psyc...
#neurojobs

Join us on Thursday to learn about the peer review system, how to effectively respond to reviews, and how to push back against unfair or biased comments 🙄

This is the first @blackinneuro.bsky.social & @reviewerzero.bsky.social collaboration – session led by @mattgoldrick.bsky.social and me!

Enhanced Mind-Matter Interactions Following rTMS Induced Frontal Lobe Inhibition A major barrier to acceptance of psi is that effects are small and hard to replicate. To address this issue, we developed a novel neurobiological mode…

Ahm, Cortex - I have questions:
www.sciencedirect.com/science/arti...
#neuroskyence #PsychSciSky

The Cognitive HEalth and Neurodegeneration Lab (CHEN Lab) in the Department of Psychology at Stony Brook University will be accepting PhD students in Integrative Neuroscience. The CHEN lab, led by Dr. Xi Chen, is focused on brain and cognitive changes in aging, including a broad spectrum ranging from older individuals with exceptional cognition (“super-agers”) to those in the early stages of Alzheimer’s disease (AD). To apply: • Please check out the lab website for more information: drxichen.com • If interested, please apply through the University’s doctoral program (Integrative Neuroscience in the Department of Psychology at Stony Brook University) before Dec 15. • For questions regarding this opportunity, please contact Dr. Xi Chen at xi.chen.8@stonybrook.edu.

The Psychology Department at Stony Brook University encompasses doctoral programs in Clinical Psychology, Cognitive Science, Integrative Neuroscience, and Social and Health Psychology. Being the birthplace of MRI, Stony Brook University has a 3 Tesla Siemens MAGNETOM Prisma MRI scanner at the Social, Cognitive, and Affective Neuroscience (SCAN) Center; a PET research facility with on-site cyclotron and research-dedicated simultaneous PET/MRI scanner and PET/CT scanners; the Center for Understanding Biology using Imaging (CUBIT); and the Stony Brook Neurosciences Institute, which includes the Center for Excellence for Alzheimer’s Disease, Neuromodulation Center, Center for Affective Neuroscience of Depression and Anxiety (CANDA), Mind-Body Clinical Research Center, and Parkinson’s and Movement Disorders Center, among others.

🚨I’m recruiting PhD students interested in neuroimaging of aging and Alzheimer’s disease to join my new lab at Stony Brook University. Deadline Dec 15. For anyone interested and going to #SfN2023, feel free to contact me! I’d love to chat in DC and answer any questions you may have! 🧠#neuroskyence

Check out our new paper in NIMG:Clinical 👇🏽 #neuroskyence #neurosky

Symposia Voting - Cognitive Neuroscience Society April 13-16  |  2024 Vote for Your Favorite Symposium! Vote for the Symposium you’d most like to see at the CNS 2024 Annual Meeting. The symposium committee will use your input, along with their o...

Hello CNS Members! Please consider voting for our symposium on "Translating cognitive neuroscience into the preclinical realm of Alzheimer's disease". Organized by Hwamee Oh and presented by me, Heidi Jacobs, @mnrajah.bsky.social and Nathan Spreng! Please RT. #PsychSciSky #neuroskyence #compneurosky

We think… “early tau deposition independent of Aβ predicts subsequent hippocampal atrophy that may lead to memory deficits in normal older individuals, whereas elevated cortical tau deposition is associated with cortical thinning that may lead to more severe memory decline in AD.” 🧠