Paresh Malhotra

Our annual conference, Connectome, is in full swing today! 

As well as excellent science talks, this morning we heard an insightful discussion between Prof Siddharthan Chandran, Prof Miratul Muqit, and journalist @rorycj.bsky.social, who generously shared his experience of living with Parkinson's.

www.podbean.com/pw/pbblog-nr...
Great podcast about the #LANDMARK project @imperialbrains.bsky.social featuring Michael Johnson and David Dexter discussing multiple important aspects of this major #Parkinson's study including #brainbank research, the #drugpipeline , #copathologies and much more...

Fantastic to hear from Professor
@johnpaultaylor.bsky.social on the final day of CTAD 2025 sharing updates from a trial exploring dementia with Lewy bodies.

It’s so important that we keep striving for progress for all causes of dementia 👏

Lovely team in Edinburgh for anyone on the hunt for a PhD
🧪

Agreed that negative trials present enormous learning opportunities. Learned long ago that the only "failed" studies are those that are poorly designed or conducted.

PhD Opportunity in Alzheimer’s Research

Seeking motivated applicants interested in advanced imaging or mathematical modelling (quantitative systems pharmacology) to investigate immune–nervous system interactions at The University of Queensland. Please reach out: p.padmanabhan@uq.edu.au

I was so lucky to have Jonny as my PhD supervisor. He was a one-of-a-kind scientist and person. He continues to be an inspiration to me and I will always be guided by the way he thought about science and life. He built an amazing network of wonderful people and we all miss you, Jonny.

Professor: Old Age Psychiatry - DEMENTIA RESEARCHER Professor of Old Age Psychiatry at University of Oxford. Lead dementia and mental health research shaping future care for older adults.

Vacancy for a Professor of Old Age Psychiatry at University of Oxford. Lead dementia and mental health research shaping future care for older adults. Closing date: 5th January

www.dementiaresearcher.nihr.ac.uk/job/professo...

Director: Queensland Brain Institute - DEMENTIA RESEARCHER The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.

The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration. Closing date: 8th December

www.dementiaresearcher.nihr.ac.uk/job/director...

A great piece about a man with a complicated legacy.

One of the many quotes:
E.O. Wilson... called him “the most unpleasant human being I had ever met”

Every year, ~120 people donate their brain and spinal cord tissue to advance #MS & #Parkinson's research. We spoke with Rory Türkmen Smith, Tissue Bank Engagement Manager, about facilitating these precious donations.

🧠 Read more: bit.ly/43ZdR0f

@imperialmed.bsky.social

Clinical Research Fellow: Disease-modifying therapies for Parkinson’s Clinical Research Fellow, Newcastle University, join Professor Camille Carroll on EJS ACT PD trial to test disease modifying therapies in Parkinsons.

Clinical Research Fellow Vacancy, Newcastle University, join Professor Camille Carroll on EJS ACT PD trial to test disease modifying therapies in Parkinsons. Closing date: 18th November

www.dementiaresearcher.nihr.ac.uk/job/clinical...

Living in a deprived neighbourhood increases your #dementia risk and now @psychiatry-ucam.bsky.social researchers know why.

@audreylow.bsky.social and Prof John O'Brien found links to brain vessel damage and poorer management of lifestyle factors known to affect dementia risk: bit.ly/3JNMxv7

🧪

Coincidentally (but v aptly) finished #LollyWillowes last night. Happy Halloween!!

The blood–brain barrier Here, Audrey Chagnot and Axel Montagne discuss the structural and functional features of the blood–brain barrier and the association of its disruption with various pathologies.

The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier.

Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot

www.cell.com/current-biol...

The value of public R&D

Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...

Policy workshop for early- and mid-career researchers Supporting early and mid-career researchers focused on dementia & neurodegenerative conditions to bridge the gap between policy & research.

Are you a postdoc researcher interested in dementia and neurodegenerative diseases?

Join us in York on 25 November for a FREE policy workshop co-hosted by #denpruQM, NIHR Three Schools' Dementia Research Programme & @i-care-dtc.bsky.social.

Interested? Find out more & sign up:
tinyurl.com/4xz7ys27

Following the launch of the Dementia Frontiers Fund, we are hosting two information webinars on the initiative and its application process.

📅 Nov 11, 0900 GMT

📅 Nov 13, 1700 GMT

Each session will include a live Q&A to address your questions.

Sign up: alzheimers.eventsair.com/dementia-fro...

How does the brain fall asleep? 💤

In a fascinating new study, scientists led by Dr Nir Grossman have been able to pinpoint, for the first time, the exact moment the brain falls asleep, and precisely map the unfolding process in real time 👉 buff.ly/mcOumTw

Clinical Future Leaders Fellowship - DEMENTIA RESEARCHER NIHR Clinical Future Leaders Fellowship with MRC, CRUK, BHF and Alzheimer’s Society offers 7-year funding for senior postdoctoral clinical academics.

NIHR Clinical Future Leaders Fellowship with MRC, CRUK, BHF and @alzsocresearch.bsky.social offers 7-year funding for senior postdoctoral clinical academics.

www.dementiaresearcher.nihr.ac.uk/funding/clin...

Over 3 billon people live with neurological disorders

1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism.

Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH

Dementia Frontiers Fund - DEMENTIA RESEARCHER Apply to the Dementia Frontiers Fund from Alzheimer's Research UK and Gates Ventures to pursue bold dementia research with staged support and multi year awards.

Apply to the Dementia Frontiers Fund (Worldwide oppertunity) from @alzheimersresearchuk.org and Gates Ventures to pursue bold #dementia research with staged support and multi year awards.

www.dementiaresearcher.nihr.ac.uk/funding/deme...

Congratulations to @hdemnitzking.bsky.social, @claudiacooper.bsky.social & team on your NIHR/ESRC APPLE-Tree publication 🎉

Harriet & Claudia are joining @ilcuk.bsky.social at the House of Lords today to launch the findings & share #denpruQM work on public health policy for dementia risk reduction.

On the edge My week in the NHS

New post just out:

"On the edge"

On my unexpected week in hospital and five things I learnt about the state of the NHS.

(Free to read)

open.substack.com/pub/samf/p/o...

We’re excited to announce that recruitment for the first multi-arm, multi-stage (MAMS) platform for Parkinson’s in the UK – EJS ACT-PD – is open. This project will continuously test new therapies that could impact Parkinson's progression.

Read more: buff.ly/W7eqbec

John Goldsmith: refugee from Nazi Germany who became a pioneer of kidney dialysis John Goldsmith overcame a tumultuous childhood and adolescence, first as a refugee from Nazi Germany and later as an interned “enemy alien,” to become an early pioneer in kidney dialysis, setting up t...

www.bmj.com/content/391/... well worth reading this if you can.

Research Assistant: Single Cell Genomics - Research Assistant or Associate in Computational Genomics at Imperial College London, with Dr Cynthia Sandor analysing single cell omics in Parkinsons

Research Assistant or Associate in Computational Genomics at Imperial College London, with Dr Cynthia Sandor analysing single cell omics in Parkinsons. Closing date: 29th October

www.dementiaresearcher.nihr.ac.uk/job/research...

Lewis Moody: Former England captain reveals motor neurone disease diagnosis Former England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview.

We must find an effective treatment for #ALS #MND

@ukmndri.bsky.social

BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...

Read an extract from Our Brains, Our Selves by Masud Husain In this passage from Our Brains, Our Selves, winner of the Royal Society Trivedi Science Book Prize, neuroscientist Masud Husain recounts how novelist Marcel Proust became convinced, wrongly, that he'd had a stroke

In this passage from Our Brains, Our Selves, winner of the Royal Society Trivedi Science Book Prize, neuroscientist Masud Husain recounts how novelist Marcel Proust became convinced, wrongly, that he'd had a stroke

We're very happy to announce that the winner of this year’s Royal Society Trivedi Science Book Prize is ‘Our Brains, Our Selves: What a Neurologist’s Patients Taught Him About the Brain’ by debut author, clinical neurologist and neuroscientist Masud Husain. #SciBooks royalsociety.org/news/2025/10...