Rodrigo Cabral-Carvalho

Thank you, @ruffini.bsky.social! Great to hear from you!

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I also want to acknowledge @robincarhartharris.bsky.social , whose work has been inspiration for my personal visions and research direction, and also @ruffini.bsky.social for his methodological insights and great conversations at the Brain Modes conference!

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In the subacute group, ΔT (condition - baseline scans) correlated with the “affect” subscale of the Hallucinogen Rating Scale (HRS), p < 0.01 and was better explained in the ayahuasca group (adj. R² = 0.58) compared to the placebo (adj. R² = -0.05).

(5/8) Main results start now: Change in Ising-inferred temperature (ΔT) was significantly higher in both the acute (p < 0.001) and subacute (24 h, p < 0.05) ayahuasca groups vs. placebo, indicating a sustained entropy elevation.

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With less prominent network changes in subacute dataset.

(3/8) Acute ayahuasca produced ↓segregation & modularity and ↑clustering & path length—especially in auditory, somatomotor & attention networks—pointing to more globally integrated, less modular dynamics as we may know.

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The main method infer Ising temperature using a GNN model, developed by me and published in Network Neuroscience (Cabral-Carvalho et al., 2025).

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• Acute dataset: n=8 regular ayahuasca users, fMRI pre vs. 40 min post-dose
• Subacute dataset: n=19 aya vs. n=18 placebo, fMRI pre vs. 24 h post
• Analyses: graph metrics (segregation, clustering, path-length, modularity, etc.) + Ising temperature

Ayahuasca Shifts Brain Dynamics Toward Higher Entropy: Persistent Elevation of Ising Temperature Correlates with Acute Subjective Effects Serotonergic psychedelics profoundly alter high-order cognition, emotion, and sensory perception, creating dynamic, unpredictable brain states consistent with the entropic brain hypothesis. Although t...

My recent work is out! a collaboration with Dr. Draulio Araujo
and Dr. F. Palhano-Fontes

What lasting neural imprint does ayahuasca leave beyond its acute experience?

Could brain stay “more entropic” subacutely? Does it relates acute subjective experience?